Chronic Graft Versus Host Disease

Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant. - Comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant - Oriented for clinicians, covers staging, organ site and system specific manifestations, treatment options, and supportive care - Interdisciplinary, with contributions from all medical subspecialties Contents Part I. General Principles: 1. History Alois Gratwohl; 2. Pathophysiology of acute GVHD Carrie Kitko and James L. M. Ferrara; 3. Pathophysiology of chronic GVHD Kirk Schultz; 4. Animal models of chronic GVHD Yu-Wayne Chu, Ronald Gress, and Warren D. Shlomchik; 5. Incidence and trends Sally Arai, Mukta Arora, and Douglas Rizzo; 6. Clinical manifestations and natural history Mary Evelyn D. Flowers and Georgia Vogelsang; 7. Risk factors and predictive models Görgün Akpek and Stephanie J. Lee; 8. Biomarkers in prediction and monitoring Ernst Holler and Anne Dickinson; Part II. Clinical Management: 9. Diagnosis and staging Madan Jagasia, Howard M. Shulman, Alexandra H. Filipovich, and Steven Pavletic; 10. Chronic GVHD pharmacology and commonly used drugs T. Hughes and Timothy McGuire; 11. Prevention of chronic GVHD Andrea Bacigalupo and Nelson J. Chao; 12. Front line treatment of chronic GVHD Paul J. Martin and Andrew L. Gilman; 13. Salvage treatment of chronic GVHD Hildegard T. Greinix and Joseph H. Antin; 14. Response measurement David Jacobsohn, Sandra A. Mitchell, and Steven Z. Pavletic; 15. General principles in ancillary and supportive care Paul A. Carpenter and Dan R. Couriel; Part III. Organ Site or System Specific Manifestations: 16. Skin Edward W. Cowen and Sharon R. Hynes; 17. Mouth Nathaniel S. Treister, Mark M. Schubert, and Jane M. Fall-Dickson; 18. Eyes Stella K. Kim, Janine A. Smith, and James P. Dunn Jr.; 19. Genitalia Maria L. Turner and Pamela Stratton; 20. Gastrointestinal (including nutritional support) Miwa Sakai and George B. McDonald; 21. Pulmonary Javier Bolaños-Meade and Jason W. Chien; 22. Hematologic Corey Cutler; 23. Neurologic Harry Openshaw; 24. Musculoskeletal Li Li, Leighton Chan, and Lynn H. Gerber; 25. Infections Juan Gea-Banacloche and Michael Boeckh; 26. Metabolic and endocrine effects Paul A. Carpenter and Jean E. Sanders; 27. Other manifestations Kristin Baird and Andrew L. Gilman; 28. Psycho-social issues Loretta Williams and Karen L. Syrjala; 29. Secondary and late effects Gérard Socié and H. J. Deeg; 30. Quality of life assessments Sandra A. Mitchell and Bryce B. Reeve; Part IV. Special Considerations in Chronic GVHD: 31. Clinical trials design Paul J. Martin, Donna Przepiorka, and Stephanie J. Lee; 32. Unique clinical situations Mohamad Mohty, Juliet N. Barker, and Claudio Anasetti; 33. Pediatric chronic GVHD Kristin Baird, Alan S. Wayne, and David A. Jacobsohn; 34. Coordination and continuity of interdisciplinary practice Viki Anders, Carina Moravec, and Sandra A. Mitchell; 35. Patient and family education, advocacy, and support groups Kathleen M. Castro, Susan Stuart, Myra J. Jacobs, and Paula Kim; 36. Future directions Stephanie J. Lee. Contributors Carrie Kitko, James L. M. Ferrara, Kirk Schultz, Yu-Wayne Chu, Ronald Gress, Warren D. Shlomchik, Sally Arai, Mukta Arora, Douglas Rizzo, Mary Evelyn D. Flowers, Georgia Vogelsang, Görgün Akpek, Stephanie J. Lee, Ernst Holler, Anne Dickinson, Madan Jagasia, Howard M. Shulman, Alexandra H. Filipovich, Steven Pavletic, T. Hughes, Timothy McGuire, Andrea Bacigalupo, Nelson J. Chao, Paul J. Martin, Andrew L. Gilman, Hildegard T. Greinix, Joseph H. Antin, David Jacobsohn, Sandra A. Mitchell, Paul A. Carpenter, Dan R. Couriel, Edward W. Cowen, Sharon R. Hynes, Nathaniel S. Treister, Mark M. Schubert, Jane M. Fall-Dickson, Stella K. Kim, Janine A. Smith, James P. Dunn Jr., Maria L. Turner, Pamela Stratton, Miwa Sakai, George B. McDonald, Javier Bolaños-Meade, Jason W. Chien, Corey Cutler, Harry Openshaw, Li Li, Leighton Chan, Lynn H. Gerber, Juan Gea-Banacloche, Michael Boeckh, Paul A. Carpenter, Jean E. Sanders, Kristin Baird, Andrew L. Gilman, Loretta Williams, Karen L. Syrjala, Gérard Socié, H. J. Deeg, Sandra A. Mitchell, Bryce B. Reeve, Paul J. Martin, Donna Przepiorka, Stephanie J. Lee, Mohamad Mohty, Juliet N. Barker, Claudio Anasetti, Kristin Baird, Alan S. Wayne, David A. Jacobsohn, Viki Anders, Carina Moravec, Sandra A. Mitchell, Kathleen M. Castro, Susan Stuart, Myra J. Jacobs, Paula Kim, Stephanie J. Lee