The Lymphoid Neoplasms

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and, finally, to the pragmatic aspects of disease management. The authors synthesise for the reader apsects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research. * Now includes Hodgkin's Disease and the acute lymphoblastic leukemias - a ‘one-stop-shop * Improved consistency of style, structure and approach between chapters * New text features - summary points, text boxes, reference annotation * Improved coverage of the basic science aspects Table of Contents: Part I: INTRODUCTION 1. Conceptual basis 2. History Part II: EPIDEMIOLOGY 3. Descriptive epidemiology 4. Causes and prevention of lymphomas 5. Immunological and genetic predisposition 6. Retroviruses 7. Herpesviruses 8. Other microorganisms Part III: IMMUNOBIOLOGY 9. Overview of the immune system 10. Ontogeny of T and NK cells 11. Ontogeny of B cells 12. Cellular immunobiology of lymph nodes and spleen 13. Cellular immunobiology of extranodal lymphoid tissue 14. Terminal B cell differentiation 15. Interleukins and the cytological composition of lymphoid neoplasms 16. Lymphocyte homing: relevance to clinical syndromes 17. Pathobiology of apoptosis in lymphocytes 18. Somatic hypermutation mechanism in the pathogenesis of lymphoid neoplasms 19. Animal models of human lymphoid neoplasms Part IV: CLASSIFICATION AND PATHOGENESIS 20. Pathological anatomy of the immune system 21. The classification of lymphoid neoplasia 22. Borderland between pathological entities: composite lymphomas 23. Cytogenetics of lymphoid neoplasia 24. Molecular basis of chromosomal translocations 25. Molecular genetics of lymphoid neoplasia 26. Gene expression patterns in lymphoma classification 27. Immunodeficieny, inherited and acquired, and lymphomagenesis 28. Chronic inflammation, including autoimmunity, and lymphogenesis Part V: PATHOLOGY AND PATHOGENESIS OF SPECIFIC LYMPHOMAS 29. Lymphoblastic lymphomas and leukemias 30. Small cell leukemias and lymphomas 31. Hairy cell leukemia 32. Mantle cell lymphomas 33. Marginal zone lymphoma 34. Follicular lymphoma 35. Burkitt's lymphoma 36. Diffuse large B-cell lymphomas 37. Hodgkin's lymphoma 38. Plasma cell neoplasms 39. NK cell lymphomas and leukemias 40. Anaplastic large cell lymphomas 41. Mycosis fungoides and Sezary Syndrome 42. Other peripheral T cell lymphomas Part VI: PRESENTING FEATURES, DIAGNOSIS, STAGING 43. Presenting features of lymphoid neoplasms 44. Histological diagnosis 45. Immunophenotyping as a diagnostic tool 46. Genetic studies in determining diagnosis and assessing prognosis 47. Radiological, ultrasound and nuclear magnetic resonance imaging 48. Radionuclide imaging 49. Staging systems and staging investigations 50. Special aspects of diagnosis in developing countries 51. Imaging in Developing Countries Part VII: GENERAL PRINCIPLES OF MANAGEMENT 52. Emergency management 53. Systemic therapy 54. Radiation therapy 55. Surgery in diagnosis and treatment 56. Assessment of response and follow up 57. Supportive care in lymphoid neoplasia 58. Prognostic factors and risk adaptation 59. Second line therapy 60. High dose therapy with stem cell rescue 61. Management of lymphoid neoplasms during pregnancy 62. Management of lymphoid neoplasms in the infant 63. Management of lymphoid neoplasms in the elderly 64. Management of lymphomas at extranodal locations 65. Management of lymphomas in developing countries 66. Late effects of treatment/quality of life Part VIII: MANAGEMENT OF SPECIFIC DISEASES 67. Lymphoblastic lymphoma and leukemia in children 68. Lymphoblastic lympomas and leukemias in adults 69. Small B cell lymphomas and leukemias with hairy cell lymphoma 70. Mantle cell lymphoma 71. Marginal zone, including MALT associated lymphomas 72. Follicular lymphoma 73. Burkitt and Burkitt like lymphomas/leukemia in children 74. Burkitt and Burkitt like lymphoma/leukemia in adults 75. Diffuse large B cell lymphoma in children 76. Diffuse large B cell lymphomas in adults 77. Hodgkin's lymphoma in adults 78. Hodgkin's lymphoma in children 79. Plasma cell neoplasms 80. Leukemias and lymphomas of NK cell origin 81. Anaplastic large cell lymphoma in adults 82. Anaplastic large cell lymphoma in children 83. Mycosis fungoides and Sezary Syndrome 84. Adult T-cell leukemia/lymphoma 85. Peripheral T cell lymphomas 86. HIV-associated lymphomas 87. Lymphoid neoplasms in individuals with underlying chronic diseases 88. Unusual lymphoid neoplasms in children Part IX: FUTURE DIRECTIONS IN DIAGNOSIS AND TREATMENT 89. Applications of genomic and epigenetic studies 90. New drugs 91. Monoclonal antibody therapy 92. Cellular therapies 93. Vaccine therapies 94. Normal Cellular Infiltrates in Diagnosis, Prognosis and Management 95. Molecular therapy 96. Viral Targeted Therapies About the Author(s): Ian Magrath, International Network for Cancer Treatment & Research, Belgium Paolo Boffetta, International Agency for Research on Cancer, Lyon, France Michael Potter, NIH, Bethesda, USA Harald Stein, University of Berlin, Germany Randy Gascoyne, British Columbia Cancer Agency, Canada Claire Dearden, Royal Marsden Hospital, Sutton, Surrey, UK Volker Diehl, University of Köln, Germany Ama Rohatiner, St Bartholomew's Hospital, London, UK Kishor Bhatia, NIH, Bethesda, USA Contributors: 14% UK 41% Europe 36% USA 9% ROW