Uremic Toxins

The book is split into four parts 1) definition, classification and a list of uremic toxins, 2) application of MS for uremic toxin research, 3) description of selected uremic toxins such as chemical structure, metabolism, analytical methods, serum levels, toxicity and clinical implication, and removal methods, and 4) therapeutic removal of uremic toxins by hemodialysis, peritoneal dialysis and oral sorbent. CONTENTS SECTION 1: UREMIC TOXINS Chapter 1. Uremic Toxins: An Integrated Overview of Definition and Classification Richard J. Glassock and Shaul G. Massry Chapter 2. Classification and a List of Uremic Toxins Nathalie Neirynck, Rita De Smet, Eva Schepers, Raymond Vanholder, and Griet Glorieux Chapter 3. Analysis of Uremic Toxins with Mass Spectrometry Toshimitsu Niwa SECTION 2: SELECTED UREMIC TOXINS Chapter 4. Indoxyl Sulfate Toshimitsu Niwa Chapter 5. p-Cresyl Sulfate Anneleen Pletinck, Raymond Vanholder, and Griet Glorieux Chapter 6. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic Acid Toshimitsu Niwa Chapter 7. Phenylacetic Acid Anna Schulz and Joachim Jankowski Chapter 8. Homocysteine and Hydrogen Sulfide: Two Opposing Aspects in the Pathobiology of Sulfur Compounds in Chronic Renal Failure Alessandra F. Perna and Diego Ingrosso Chapter 9. Guanidino Compounds Sunny Eloot, Griet Glorieux, Peter Paul De Deyn, and Raymond Vanholder Chapter 10. Asymmetric Dimethylarginine Vladimír Teplan and Jaroslav Racek Chapter 11. Nicotinamide Metabolites Przemyslaw Rutkowski and Boleslaw Rutkowski Chapter 12. Dicarbonyls (Glyoxal, Methylglyoxal, and 3-Deoxyglucosone) Naila Rabbani and Paul J Thornalley Chapter 13. Glucose Degradation Products in Peritoneal Dialysis Monika Pischetsrieder and Sabrina Gensberger Chapter 14. Dinucleoside Polyphosphates Joachim Jankowski and Vera Jankowski Chapter 15. Parathyroid Hormone Shaul G. Massry and Miroslaw Smogorzewski Chapter 16. β2-Microglobulin Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei Narita, and Fumitake Gejyo Chapter 17. Cytokines Björn Anderstam, Bengt Lindholm, and Peter Stenvinkel Chapter 18. Free Immunoglobulin Light Chains Gerald Cohen and Walter H. Hörl Chapter 19. Advanced Glycation End-Products (AGEs) Naila Rabbani and Paul J Thornalley Chapter 20. Oxidized Albumin Maurizio Bruschi, Giovanni Candiano, Laura Santucci, and Gian Marco Ghiggeri SECTION 3: THERAPEUTIC REMOVAL OF UREMIC TOXINS Chapter 21. Therapeutic Removal of Uremic Toxins by Hemodialysis Tammy L. Sirich, Pavel Aronov, and Timothy W. Meyer Chapter 22. Therapeutic Removal of Uremic Toxins by Peritoneal Dialysis Malgorzata Debowska, Elvia García-López, Jacek Waniewski, and Bengt Lindholm Chapter 23. Therapeutic Removal of Uremic Toxins by Oral Sorbent Toshimitsu Niwa