New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood. Features • Includes comprehensive diagnosis, risk assessment and treatment of all subtypes of childhood leukemias, aiding accurate management of children with leukemia • Contains numerous high-quality figures and tables, enabling quick learning • Describes the most up-to-date clinical, translational and basic research in leukemia, and addresses future directions Table of Contents Preface Part I. History and General Issues: 1. History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel 2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui 3. Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison Part II. Cell Biology and Pathobiology: 4. Immunophenotyping Fred G. Behm 5. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak 6. Cytogenetics of acute leukemias Susana C. Raimondi 7. Molecular genetics of acute lymphoblastic leukemias Charles Mullighan 8. Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing 9. Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero 10. Genetics and cellular drug resistance in acute leukemia Monique L. den Boer and Rob Pieters 11. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange Part III. Evaluation and Treatment: 12. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary V. Relling and Williams E. Evans 13. Acute lymphoblastic leukemia Ching-Hon Pui 14. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg 15. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Mihaela Onciu 16. Acute myeloid leukemia Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro 17. Relapsed acute myeloid leukemia Ursula Creutzig 18. Myelodysplastic syndromes Henrik Hasle 19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli 20. Leukemias in patients with Down syndrome Jeffrey W. Taub, April Sorrell and James A. Whitlock 21. Treatment of adolescents and young adults with acute lymphoblastic leukemia James Nachman 22. Hematopoietic stem cell and natural killer cell transplantation Wing Leung and Michael A. Pulsipher 23. Treatment in the underprivileged countries Raul Ribeiro, Scott C. Howard and Ching-Hon Pui 24. Antibody-targeted therapy Alan S. Wayne 25. Adoptive cellular immunotherapy Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop 26. Gene therapy: methods and applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner 27. Development therapeutics Sima Jeha 28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen Part IV. Complications and Supportive Care: 29. Acute complications Scott C. Howard, Raul Ribeiro and Ching-Hon Pui 30. Late complications after leukemia therapy Melissa Hudson 31. Therapy-related leukemias Carolyn A. Felix 32. Infectious complications Hana Hakim and Patricia M. Flynn 33. Hematologic supportive care Fariba Navid and Victor M. Santana 34. Pain management Doralina L. Anghelescu and Roland Kaddoum 35. Psychosocial issues Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull 36. Nursing care Jami S. Gattuso, Martha May and Michele Pritchard Index.