Pediatric Hematology

Hematology is often considered a challenging subject by students and junior medical staff alike. Using key scientific and clinical principles, this succinct guide provides a summary of modern day-to-day clinical practice in paediatric hematology. Focusing on the facts that underpin patient management, each chapter offers an initial summary of a particular paediatric hematologic condition. Several key clinical scenarios set out how common difficulties should be managed, from the neonate with line thrombosis, to the newly presenting patient with leukaemia, and the child who has suffered a stroke. Covering all hematology topics on the syllabus of the American Board of Paediatrics subspecialty examinations, this authoritative guide is ideal for both postgraduates and junior doctors, whose understanding of hematological conditions will increase greatly upon reading. This comprehensive and practical book specifically aims to equip clinicians to diagnose and manage children with hematological illness, and to support them and their families.

    Succinct chapters provide a quick-reference overview of evidence-based guidelines for the more experienced haematologist
    Each clinical scenario includes advice on how to manage the patient and, if appropriate, how to communicate with children and their families
    Chapters include colour images and flowcharts, and follow a standardised format for ease of reading

Table of Contents

1. Normal hemopoiesis and the physiology of blood
2. The coagulation system
3. Common laboratory tests used in hematology and how to interpret them
4. Reference ranges in children
Clinical scenario 1. The child with newly presenting acute leukemia
5. Neonatal anemia
6. Neonatal abnormal myelopoiesis and the hematology of Down syndrome
7. Neonatal thrombocytopenia
8. Neonatal bleeding disorders
Clinical scenario 2. Hyperleucocytosis
9. Neonatal thrombotic disorders
10. Inherited bone marrow failure syndromes
11. Acquired bone marrow failure syndromes: aplastic anemia
12. Sideroblastic anemia
Clinical scenario 3. Management of the child with a mediastinal mass
13. Iron deficiency
14. Disorders of vitamin B12 and folate
15. Hemolytic anemia
16. Infections in hematology patients and the hematological features of infectious disease
Clinical scenario 4. The approach to the neutropenic child with fever
17. Sickle cell disease
18. Thalassemia
19. Neutropenia
20. Neutrophil function disorders
Clinical scenario 5. The approach to the child with pancytopenia
21. Inherited thrombocytopenia
22. Acquired thrombocytopenia and immune thrombocytopenia purpura (ITP)
23. Immune deficiency
24. Hemophagocytic Lymphohistiocytosis (HLH) and other non-malignant histiocytic disorders
Clinical scenario 6. Does this child have lymphoma?
25. Osteopetrosis
26. Hemophilia
27. Congential and acquired von Willebrand disease
28. Rare inherited bleeding disorders
Clinical scenario 7. Diamond-Blackfan anemia, transient erythroblastopenia or other cause of red cell aplasia in children
29. Acquired bleeding disorders
30. Venous thrombosis in children
31. Arterial thrombosis in children
32. Stroke in children
Clinical scenario 8. Approach to evaluation for a bleeding disorder in a child with suspected non-accidental injury (NAI)
33. Anticoagulation in children
34. Blood transfusion indications and safe use in children
35. Adverse reactions to blood products and special transfusion circumstances
36. Acute lymphoblastic leukemia
Clinical scenario 9. The neonate with catheter related thrombosis
37. Acute myeloid leukemia
38. Juvenile myelomonocytic leukemia (JMML) and myelodysplastic syndromes (MDS)
39. Principles of blood and marrow transplantation
Clinical scenario 10. Neonatal renal vein thrombosis.

Robert Wynn, Central Manchester University Hospitals
Robert Wynn is Professor of Paediatric Haematology at the University of Manchester, and Consultant Paediatric Haematologist and Director of the Paediatric Blood and Marrow Transplant Programme at the Royal Manchester Children's Hospital.

Rukhmi Bhat, Northwestern University Feinberg School of Medicine, Chicago
Rukhmi Bhat is Assistant Professor of Pediatrics at the Feinberg School of Medicine, Northwestern University, Illinois, and Attending Physician in Hematology/Oncology/Stem Cell Transplant at the Ann and Robert H. Lurie Children's Hospital, Chicago.

Paul Monagle, University of Melbourne, Australia
Paul Monagle is Stevenson Professor and Head of the Department of Paediatrics at the University of Melbourne, and Former Director of the Department of Haematology at the Royal Children's Hospital, Melbourne.