Sudden Cardiac Death in the Young and Athletes

This text atlas focuses on the pathology and molecular genetics of sudden cardiac death in the young and in athletes, presenting the state of the art in the field as the basis for development and implementation of more effective prevention strategies, including, ultimately, molecular therapy that will cure the underlying biological defect. A wealth of high-resolution color images, accompanied by clear supporting text, are presented to document the anatomic pathology of the cardiac diseases most frequently responsible for sudden cardiac death in this population, including coronary artery diseases, cardiomyopathies, myocarditis, valve diseases, conduction system abnormalities, congenital heart diseases, and ion channel diseases. The role of the molecular autopsy in overcoming the limitations of morphological investigations and offering new insights and avenues for prevention is explained. The approach is, however, interdisciplinary, with close attention also to epidemiologic and clinical aspects. The authors draw throughout on their experience gained over 30 years in the course of a prospective study carried out in the Veneto Region, North East Italy. This text atlas will be of great value not only for cardiologists but also for geneticists, sports physicians, and residents in cardiology and pathology.

Table of contents (13 chapters)

        Introduction

        Thiene, Gaetano (et al.)

        Definition, Epidemiology, and Pathophysiologic Mechanisms

        Thiene, Gaetano (et al.)

        Pages 3-20

        Coronary Artery Disease

        Thiene, Gaetano (et al.)

        Pages 21-71

        Cardiomyopathies

        Thiene, Gaetano (et al.)

        Pages 73-96

        Myocarditis

        Thiene, Gaetano (et al.)

        Pages 97-108

        Valve Disease

        Thiene, Gaetano (et al.)

        Pages 109-122

        Conduction System Disease

        Thiene, Gaetano (et al.)

        Pages 123-135

        Congenital Heart Disease

        Thiene, Gaetano (et al.)

        Pages 137-142

        Ion Channel Disease

        Thiene, Gaetano (et al.)

        Pages 143-147

        How to Study Sudden Death at Autopsy: Protocol of Investigation

        Thiene, Gaetano (et al.)

        Pages 149-164

        Molecular Pathology and Genetic Testing

        Thiene, Gaetano (et al.)

        Pages 165-169

        The Northeast Italy, Veneto Region Experience

        Thiene, Gaetano (et al.)

        Pages 171-181

        Prevention of Sudden Cardiac Death

        Thiene, Gaetano (et al.)

        Pages 183-188