Narcolepsy

This interdisciplinary volume brings together many of the world's leading clinicians and researchers to discuss current and anticipated developments in the understanding of narcolepsy. The volume is broadly divided into four main sections: Section I: Etiology; Section II: Clinical Considerations; Section III: Psychosocial considerations; and Section IV: Management. The areas covered include findings from research investigations on the genetic predisposition and pathophysiology, psychosocial aspects, and clinical management of narcolepsy by means of pharmacological and non-pharmacological methods. Special attention is paid to the translational aspects of narcolepsy. This volume is suitable for sleep disorders specialists and researchers, psychiatrists, neurologists, psychologists, social workers, behavioral scientists, graduate medical students, and any professionals and researchers interested in the interdisciplinary area of sleep medicine. Key Features · Focus on issues faced in day-to-day clinical settings - helps to inform and change clinical practice · Chapters address both clinical and research basis - highlights potential areas of future research · Interdisciplinary and translational approach - suitable for a wide range of clinicians and biomedical professionals Meeta Goswami, BDS, PhD, MPH, has been the director of the Narcolepsy Institute since its inception in 1985 and serves as an Assistant Professor of Neurology, Albert Einstein College of Medicine. Her general area of research interest includes narcolepsy and psychosocial issues. S.R. Pandi-Perumal, M.Sc, is the President and Chief Executive Officer of Somnogen Inc, a New York Corporation. He is a well-recognized sleep researcher both nationally and internationally, and has authored many publications. His general area of research interest includes sleep and biological rhythms. He is a well-known editor in the field of sleep medicine and has edited over 15 volumes dealing with various sleep-related topics. Michael J Thorpy, MD, has won many awards for his research including one of the sleep field's highest honors: the Nathaniel Kleitman Award. He is a well-published researcher and a board-certified sleep physician. He serves as a Professor of Neurology at Albert Einstein College of Medicine and the Director of the Sleep-Wake Disorders Center at Montefiore Medical Center, Bronx, New York. Table of contents Foreword Clifford C. Saper, MD, PhD Preface Editors Credits and Acknowledgements Editors   SECTION I: ETIOLOGY 1. Narcolepsy: Genetic predisposition and pathophysiology Emmanuel Mignot, MD, PhD. 2. Animal models of narcolepsy: Developments, findings, and perspectives Christopher M. Sinton, PhD. 3. Neuroimaging of narcolepsy Eric A. Nofzinger, MD.   SECTION II: CLINICAL CONSIDERATIONS 4. Epidemiology of narcolepsy Lauren Hale, PhD. 5. Narcolepsy in Childhood Shalini Paruthi, MD. & Suresh Kotagal, MD. 6. Narcolepsy in the Older Adult Hrayr Attarian, MD. 7. Diurnal and nocturnal sleep in narcolepsy with cataplexy Yves Dauvilliers, MD, PhD & Giuseppe Plazzi, MD, PhD 8. Hypnagogic Hallucinations and Sleep Paralysis Armando D'Agostino, MD & Ivan Limosani, MD. 9. REM sleep behaviour disorder in narcolepsy with cataplexy. Giuseppe Plazzi, MD, PhD & Yves Dauvilliers, MD, PhD. 10. Narcolepsy and other comorbid medical illnesses Lori A. Panossian, MD & Alon Y. Avidan, MD, MPH. 11. Humor processing in human narcolepsy with cataplexy Aurélie Ponz & Sophie Schwartz, PhD. 12. Dreams in patients with narcolepsy Michael Schredl 13. Psychoanalysis and narcolepsy James F Pagel, MS, MD & Lawrence Scrima, PhD 14. Symptomatic narcolepsy or hypersomnia, with and without hypocretin (orexin) deficiency Kanbayashi T, Nakamura M, Shimizu T, & Seiji Nishino, MD, PhD. 15. Hypersomnias other than narcolepsy: Differential diagnosis Michel Billiard, MD.   SECTION III: PSYCHOSOCIAL CONSIDERATIONS 16. Psychosocial impact of narcolepsy in children and adolescents Gregory Stores MA, MD, DPM, FRCPsych, FRCP. 17. Quality of life and psychosocial issues in narcolepsy Meeta Goswami BDS, MPH, PhD. 18. Narcolepsy, Intimacy and Sexuality Gila Lindsley, Ph.D. 19. Narcolepsy, driving and traffic safety Claire EHM Donjacour, Monique AJ Mets, Joris C Verster, PhD. 20. Memory and Cognition in Narcolepsy Christian Bellebaum, & Irene Daum, PhD. 21. Medico-legal aspects of disability in narcolepsy Francesca Ingravallo and Giuseppe Plazzi 22. Narcolepsy and mental health John Shneerson, MA, DM, MD, FRCP, FCCP SECTION IV: MANAGEMENT 23. Overview of management of narcolepsy Seiji Nishino, MD, PhD. 24. Modes of action of drugs related to narcolepsy: Pharmacology of wake-promoting compounds and anticataplectics Seiji Nishino, MD, PhD & Nozomu Kotorii, MD, PhD. 25. Modafinil/ Armodafinil in the Treatment of Narcolepsy Michael Thorpy, MD 26. Sodium oxybate in the treatment of narcolepsy Geert Mayer 27. Emerging treatments for narcolepsy Meredith Broderick MD & Christian Guilleminault MD, BiolD. 28. Non-pharmacologic Treatments of Narcolepsy Renee Monderer, MD, Shelby Freedman Harris, PsyD, CBSM. & Michael J. Thorpy, MD.