A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, students, scientists, and doctors working, learning, and teaching in the field of TB. It contains 100 color photographs and illustrations that bring clarity to the information presented. The atlas takes the unusual approach of covering multiple species histopathology, arguably the first and quite possibly the only resource to do so. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists to distinguish between the features of all major animal models available and to use them with their strengths and limitations in mind. The book provides guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates. Features * Provides a starting point for non-histopathologists to understand the histopathology of TB and how it relates to their research work * Reviews the basic features necessary to understand the functional and pathological changes that can occur in this organ * Summarizes new microbiological and histological observations in the Wistar rat TB model * Focuses on general aspects of drug discovery in addition to specific points relating to TB * Includes 100 color photographs and illustrations CONTENTS Drug Discovery for Neglected Diseases of the Developing World, P. Herrling Background The Drug Discovery Process Therapeutic Tools Drug Discovery Phases Phase I–Phase IIa Phase IIb–Phase III References Tuberculosis Biology and Drug Discovery, T. Dick Disease Manifestations and Treatment A Largely Unment Medical Need The Challenge of TB Drug Discovery An At las for TB Drug Discovery References Immunopathology of Tuberculosis Disease across Species, V. Dartois Overview of Species Specific Characteristics A Macroscopic View of TB-Infected Lungs across Species Summary and Lessons Learned References Anatomy and Histology of the Human Lung, F.J.W.-M. Leong and A. S.-Y. Leong Gross Structure Microscopic Structure References Pathology of Tuberculosis in the Human Lung, F.J.W.-M. Leong, S. Eum, L.E. Via, and C.E. Barry, 3rd Introduction Features Variations References Pulmonary Tuberculosis in Monkeys, J.L. Flynn and E. Klein Introduction Inoculum and Route of Infection Features Variations Strengths of This Animal Model Shortcomings References Pulmonary Tuberculosis in the Rabbit, G. Kaplan and L. Tsenova Introduction Inoculum and Route of Inoculation Features Strengths of This Animal Model Shortcomings References Pulmonary Tuberculosis in the Guinea Pig, R.J. Basaraba and I.M. Orme Introduction Inoculum and Route of Inoculation Features Strengths of This Animal Model Shortcomings References Pulmonary Tuberculosis in the Rat, A. Singhal, E.M. Aliouat, C. Creusy, G. Kaplan, and P. Bifani Introduction Inoculum and Route of Inoculation Features Variations Strengths of This Animal Model Shortcomings References Pulmonary Tuberculosis in the Mouse, S. Bharath and V. Balasubramanian Introduction Inoculum and Route of Inoculation Features Variations Strengths of This Animal Model Shortcoming References Glossary Index Franz Joel Leong,  Novartis Institute for Tropical Diseases, Singapore ;  Veronique Dartois,  Novartis Institute for Tropical Diseases, Singapore ;  Thomas Dick,  Novartis Institute for Tropical Diseases, Singapore Editorial Reviews "This book is an excellent introduction to pulmonary tuberculosis and the physiologic, pathologic, and political hurdles as to why it has been such a difficult disease to contend with. The authors explain the intricacies of the tuberculin bacterium, the host defenses, and the theories behind current treatment modalities. The atlas is designed as a concise resource for researchers working in the field and the laboratory to evaluate the pulmonary pathologic response to the Mycobacterium organism and design more successful treatment and disease eradication for human and animal species. The multitude of photomicrographs and gross pathology photographs are of excellent quality and well-labeled. The text is well written, organized in an easy to read format, and well-referenced for further research." —Sandra L. Jex, DVM, in alnmag.com