Fully rewritten and updated for the cutting-edge 6th edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists. Features • Authoritative reference text on non-neoplastic and neoplastic lung diseases, written by leading world experts • Extensive high-quality color illustrations aid understanding and diagnosis of common and rare diseases • Thoroughly reworked new edition, including new classification schemes and clinical, radiographic, pathogenetic and molecular coverage of all recognized lung diseases Table of Contents Preface 1. The normal lung: histology, embryology, development, aging and function Neil Sahasrabudhe, John Gosney and Philip Hasleton 2. Specimen handling and practical considerations Leslie Anne Litzky and Anthony Gal 3. Congenital abnormalities and pediatric lung diseases, including neoplasms Stephen J. Gould, A. K. Webb and Anna Kelsey 4. Bacterial infections of the lung Mark Woodhead, Mary Klassen-Fischer, Ronald C. Neafie, Ann-Marie Nelson, Jeffrey R. Galvin and Teri J. Franks 5. The pathology of respiratory viral infection Richard L. Kradin and Jay Fishman 6. Pulmonary mycobacterial infections Luciane Dreher Irion and Mark Woodhead 7. Pulmonary mycotic infections Malcolm Richardson, Caroline Moore, Said Hafez-Khayyata, Carol Farver and Philip Hasleton 8. Parasitic lung disease Sebastian Lucas, Philip Hasleton, Ann Nelson and Ronald C. Neafie 9. Acute lung injury William A. H. Wallace, A. John Simpson and Nik Hirani 10. Interstitial lung diseases Andrew G. Nicholson and Alexandra J. Rice 11. Metabolic and connective tissue disorders Gail Amir and Annick Raas-Rothschild 12. Hypersensitivity pneumonitis John C. English 13. Sarcoidosis Douglas B. Flieder, Abraham Sanders and Michael N. Koss 14. Occupational lung disease Thomas Sporn and Victor L. Roggli 15. Eosinophilic lung disease Henry D. Tazelaar, Joanne Wright and Jay H. Ryu 16. Drug and therapy induced lung injury Mary Beth Beasley and Glenn A. Rudner 17. Chronic obstructive pulmonary disease and diseases of the airways Wim Timens, Hannie Sietsma and Joanne Wright 18. Vascular pathology in pulmonary hypertension Katrien Grünberg and Wolter J. Mooi 19. Pulmonary vasculitis and pulmonary hemorrhage syndromes Eugene J. Mark, Rex Neal Smith, John H. Stone, Douglas B. Flieder, Amita Sharma and Osamu Matsubara 20. The pathology of lung transplantation Gerald J. Berry and Helen M. Doran 21. The lungs in connective tissue disease Donald G. Guinee, Jr and William D. Travis 22. Benign epithelial neoplasms and tumor-like proliferations Douglas B. Flieder 23. Pulmonary preinvasive disease Keith M. Kerr 24. Epidemiologic and clinical aspects of lung cancer Erik Thunnissen, Michael Unger and Douglas B. Flieder 25. Lung cancer staging Eric Lim and Peter Goldstraw 26. Immunoperoxidase in the diagnosis of pulmonary tumors Paul William Bishop 27. Adenocarcinoma of the lung Douglas B. Flieder, Alain Borczuk and Masayuki Noguchi 28. Squamous cell carcinoma Douglas B. Flieder and Elisabeth Brambilla 29. Large cell carcinoma and adenosquamous carcinoma of the lung Sylvie Lantuejoul, Michèle Fior-Gozlan, Gilbert R. Ferretti and Denis Moro-Sibilot 30. Salivary gland neoplasms Sanja Dacic, Sebastian Gilbert, Iclal Ocak and Joan Lacomis 31. Neuroendocrine tumors and other neuroendocrine proliferations John R. Gosney 32. Sarcomatoid carcinomas and variants Yukio Nakatani, Kenzo Hiroshima and Eugene J. Mark 33. Mesenchymal and miscellaneous neoplasms T. C. Allen, P. T. Cagle and Douglas B. Flieder 34. Pulmonary lymphproliferative diseases Bruce J. Addis 35. Metastases involving the lungs Bruno Murer, Marco Chilosi, Philip Hasleton and Douglas B. Flieder 36. Diseases of the pleura Philip Hasleton, Francoise Galateau-Salle, Juliet King, Giulio Rossi, Sylvie Lantuejoul, Rebecca Preston, Durgesh N. Rana and Godfrey Wilson Index.