Acute Coronary Syndromes: A Companion to Braunwald's Heart Disease

  Acute Coronary Syndromes-a Companion to Braunwald’s Heart Disease-covers the state-of-the-art scientific and clinical information you need to rapidly evaluate and manage acute coronary syndromes. Dr. Pierre Theroux and his team of expert contributors present advances in diagnostic and imaging techniques such as biomarkers, nuclear cardiology, echocardiography, and multislice CT; secondary prevention; and new antiplatelet, anti-ischemic, and gene therapies…in print and online. New to this edition * Access the fully searchable contents of the book online at expertconsult.com. * See techniques and procedures in greater detail and clarity through the all-new full-color design. * Approach treatment with a global perspective from the new section on Population-Based Perspective that discusses the INTERHEART study, insights from the REACH registry, lessons learned from European registries, and ACS in North America. * Gain a comprehensive understanding of ACS through coverage of pathophysiology, molecular mechanisms, the role of the immune system, and brand-new chapters on cell necrosis and cell regeneration and pharmacogenetics in the section on Disease-Based Perspectives. Integrate the latest testing and treatment techniques into your practice thanks to new chapters on biomarkers in acute ischemic heart disease; the role of noninvasive testing in prognostic risk stratification; the culprit lesions and patient at risk; non-responsiveness to antiplatelet therapy; bleeding in the acute coronary syndromes; and the refractory patient. Pierre Theroux , MD, Professor of Medicine, University of Montreal; Head Coronary Care Unit, Montreal Heart Institute, Montreal, Canada CONTENTS of the previous edition: Part 1 ACS and clinical practice: from pre-infarction angina to acute coronary syndromes: the history of unstable angina; the dimension of the problem, national and international statistics, the cost for the society; an epidemiological perspective; society, environment, risk factors, and genetic; natural history and prognosis in unstable angina; organization and structure of the coronary care units in the years 2000. Part 2 Pathophysiology: pathology of acute and stable coronary syndromes; molecular mechanisms of the acute coronary syndromes - the roles of inflammation and immunity; endothelial function and acute coronary syndromes; infection; triggers to acute coronary syndromes; novel risk factors for ACS; what cardiologists need to know about depression. Part 3 Diagnosis: clinical recognition of acute coronary syndromes; the role of ECG, ECG monitoring and provocative stress testing in acute coronary syndromes; biochemical markers of myocardial necrosis; markers of a thrombotic state; markers of inflammation; angiographic characterization of the culprit lesion in ACS; nuclear cardiology in acute coronary syndromes; echocardiography in acute coronary syndromes; cardiac magnetic resonance; computed tomography for acute coronary syndromes; emerging diagnostic procedures for vulnerable plaque; ACS in the emergency department: diagnosis, risk stratification and management; ACS in the CCU; risk stratification in unstable angina/non-stable elevation myocardial infarction. Part 4 Special subgroups: the elderly, woman and patient with diabetes; coronary artery spasm; cocaine and other environmental causes of acute coronary syndromes; the patient with chest pain despite normal coronary angiography; the patient with disabling angina not amenable to revascularization (ECP, TMR, IABC, PMR, spinal chord stimulation); pharmacologic management; nitrates and nitric oxide donors; beta-blockers and calcium channel blockers (CCBs) - use in acute coronary syndromes; ATP-sensitive potassium channels, adenosine and preconditioning; metabolic interventions; antiplatelet therapy; anticoagulants in acute coronary syndromes; anti-thrombotic management; treatment of cardiovascular inflammation; acute plaque passivation and endothelial therapy; perspective for gene therapy; myocardial cell protection. Part 5 Revascularization: revascularization in acute coronary syndromes: which patients and when?; advantages and hazard of early revascularization; new revascularization procedures, surgical and percutaneous; cardiovascular regeneration and stem cell differentiation in myocardial ischemia; pharmacological revascularization. Part 7 From the Acute to the Chronic Phase. 48. Control of Risk Factors. 49. Dietary Intervention in the Coronary Care Units and in Secondary Prevention . VIII. Outlook to the Future. 50. ACS: Outlook to the Future. IX. Guidelines for Management. 51. Guidelines for Management: AHA/ACC and ESC Task Forces