Stroke Prevention and Treatment

Stroke is the second leading cause of death and a leading cause of disability worldwide. This invaluable reference provides clinicians caring for stroke patients with ready access to the optimal evidence for best practice in stroke prevention, acute stroke treatment, and stroke recovery. Now an edited volume, the editors and authors, many of whom are members of the Cochrane Stroke Review Group, describe all available medical, endovascular, and surgical treatments; the rationale for using them; and the strength of the evidence for their safety and effectiveness. New chapters cover key, rapidly advancing therapeutic topics, including prehospital stroke care and regionalized stroke systems, endovascular reperfusion therapy, and electrical and magnetic brain stimulation to enhance recovery. This is an essential resource for clinicians translating into practice the many dramatic advances that have been made in the treatment and prevention of stroke, and suggesting the most appropriate interventions.

    Discussion of the results of systematic reviews of randomized controlled trials of interventions provides clinicians with a current, evidence-based overview of stroke care
    Interpretation of the current evidence by an international panel of leading experts facilitates translation of best evidence into best practice
    New coverage of primary prevention of stroke, and stroke rehabilitation and recovery, in addition to continued in-depth coverage of secondary stroke prevention and acute stroke treatment, ensures clinicians can find the advice relevant to their patients' needs

Table of Contents

Part I. Foundations:
1. Stroke: the size of the problem Graeme J. Hankey
2. Understanding evidence Jeffrey L. Saver and Graeme J. Hankey
Part II. Systems of Care:
3. Prehospital stroke care and regionalized stroke systems Kori Sauser Zachrison and Lee Schwamm
4. Organized stroke care Peter Langhorne
Part III. Acute Treatment of Ischemic Stroke and Transient Ischemic Attack:
5. Supportive care during acute cerebral ischemia Askiel Bruno, Subhashini Ramesh and Jeffrey L. Saver
6. Reperfusion of the ischemic brain by intravenous thrombolysis Jeffrey L. Saver and Joanna Wardlaw
7. Reperfusion of the ischemic brain by endovascular thrombectomy and thrombolysis Meng Lee and Jeffrey L. Saver
8. Collateral flow enhancement: blood pressure lowering and alteration of blood viscosity Else Sandset and Eivind Berge
9. Acute antiplatelet therapy for the treatment of ischemic stroke and transient ischemic attack Jeffrey L. Saver
10. Acute anticoagulant therapy for the treatment of acute ischemic stroke and transient ischemic attack Xinyi Leng and Lawrence Wong
11. Treatment of brain edema Jeffrey L. Saver and Salvador Cruz-Flores
12. Neuroprotection for acute brain ishemica Jeffrey L. Saver and Nerses Sanossian
Part IV. Acute Treatment of Hemorrhagic Stroke:
13. Acute treatment of intracerebral hemorrhage Tom Moullaali, Rustam Al-Shahi Salman and Craig Anderson
14. Acute treatment of subarachnoid hemorrhage Sherri Braksick and Alejandro Rabinstein
Part V. Prevention:
15. Prevention of stroke by lowering blood pressure Meng Lee, Jeffrey L. Saver and Bruce Ovbiagele
16. Prevention of stroke by lowering blood cholesterol concentrations Maurizio Paciaroni
17. Prevention of stroke by modification of additional vascular and lifestyle risk-factors Amytis Towfighi and Jeffrey L. Saver
18. Drugs, devices and procedural therapies to prevent recurrent cardiogenic embolic stroke Graeme J. Hankey
19. Long-term antithrombotic therapy for large and small artery occlusive disease Graeme J. Hankey
20. Carotid and vertebral artery revascularization Mandy D. Müller, Leo H. Bonati and Martin M. Brown
21. Cervical artery dissections and cerebral vasculitis Philippe Lyrer
22. Prevention of intracerebral and subarachnoid hemorrhage James Klaas and Robert Brown
Part VI. Stroke Rehabilitation and Recovery:
23. Evidence-based motor rehabilitation after stroke Gert Kwakkel and Janne Veerbeek
24. Language and cognitive rehabilitation after stroke Marian Brady and Jonathan Evans
25. Using pharmacotherapy to enhance stroke recovery Larry Goldstein
26. Electrical and magnetic brain stimulation to enhance post-stroke recovery Mark Parsons and Jodie Marquez.

Jeffrey L. Saver, David Geffen School of Medicine, University of Ca
Jeffrey L. Saver is Professor and SA Vice-Chair of Neurology, University of California, Los Angeles (UCLA), and Director of the UCLA Comprehensive Stroke and Vascular Neurology Program.

Graeme J. Hankey, University of Western Australia, Perth
Graeme J. Hankey is Professor of Neurology, University of Western Australia, and Neurologist at Sir Charles Gairdner Hospital, Perth, Australia.

Contributors

Graeme J. Hankey, Jeffrey L. Saver, Kori Sauser Zachrison, Lee Schwamm, Peter Langhorne, Askiel Bruno, Subhashini Ramesh, Joanna Wardlaw, Meng Lee, Else Sandset, Eivind Berge, Xinyi Leng, Lawrence Wong, Salvador Cruz-Flores, Nerses Sanossian, Tom Moullaali, Rustam Al-Shahi Salman, Craig Anderson, Sherri Braksick, Alejandro Rabinstein, Bruce Ovbiagele, Maurizio Paciaroni, Amytis Towfighi, Mandy D. Müller, Leo H. Bonati, Martin M. Brown, Philippe Lyrer, James Klaas, Robert Brown, Gert Kwakkel, Janne Veerbeek, Marian Brady, Jonathan Evans, Larry Goldstein, Mark Parsons, Jodie Marquez