Pathology of the Mediastinum

This book provides a comprehensive, up-to-date review of the pathology of the neoplastic and non-neoplastic diseases that occur in the mediastinum. The pathologic and relevant clinical features are discussed, and detailed diagnostic criteria for various diseases are given, along with information about the most relevant laboratory tests. The features of thymomas, thymic carcinomas, neuroendocrine carcinomas and germ cell tumors are discussed in detail, including the utilization of immunostains and other ancillary tests in diagnosing these diseases. An algorithmic approach to the differential diagnosis of mediastinal lymphomas is given, and a novel clinico-pathologic classification helps readers diagnose and treat thymomas. Cardiac lesions, mesothelioma and other intrathoracic lesions are also reviewed. The book features more than 650 images, and downloadable copies of these are included on a CD-ROM, packaged with the print book. Pathology of the Mediastinum will be of interest to practising surgical pathologists, thoracic surgeons, oncologists and radiologists. Alberto M. Marchevsky, MD is Director of Pulmonary and Mediastinal Pathology, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, and Clinical Professor of Pathology, David Geffen UCLA School of Medicine, Los Angeles, CA, USA. Mark R. Wick, MD is Professor of Pathology, Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA. Table of Contents Preface; 1. The mediastinum Alberto M. Marchevsky and Mark R. Wick; 2. Imaging of the mediastinum Xiaoqin Wang and Ajay Singh; 3. Inflammatory diseases of the mediastinum Alberto M. Marchevsky and Mark R. Wick; 4. The thymus gland Alberto M. Marchevsky and Mark R. Wick; 5. Pathology of non-neoplastic conditions of the thymus Alberto M. Marchevsky and Mark R. Wick; 6. Low-grade and intermediate-grade malignant epithelial tumors of the thymus: thymomas Alberto M. Marchevsky, Saul Suster and Mark Wick; 7. High-grade malignant epithelial tumors of the thymus: primary thymic carcinomas Mark R. Wick, Alberto M. Marchevsky and Saul Suster; 8. Neuroendocrine tumors of the thymus Alberto M. Marchevsky, Saul Suster and Mark R. Wick; 9. Germ cell tumors of the mediastinum Sean R. Williamson and Thomas M. Ulbright; 10. Parathyroid lesions, paragangliomas, thyroid tumors, and pleomorphic adenomas of the mediastinum Mark R. Wick and Alberto M. Marchevsky; 11. Hematopoietic neoplasms of the mediastinum Serhan Alkan; 12. Cystic lesions of the mediastinum Alberto M. Marchevsky and Mark R. Wick; 13. Mesenchymal tumors of the mediastinum Bonnie Balzer, Mark R. Wick and Susan Parson; 14. Tell me what you need, so I'll know what to say Frank C. Detterbeck; 15. Clinical pathology of disorders of the mediastinum Kent Lewandrowski; 16. Surgical pathology of the heart Gregory A. Fishbein, Atsuko Seki and Michael C. Fishbein; 17. Morphologic alterations of serous membranes of the mediastinum in reactive and neoplastic settings Aliya N. Husain and Thomas Krausz; Index.