Written and edited by leading clinicians and researchers in sleep medicine, this is the first book to focus on the causes, consequences and treatment of disorders of excessive sleepiness. Extensive coverage is provided for all known causes of sleepiness, including sleep deprivation, obstructive sleep apnea syndrome, narcolepsy and other hypersomnias of central origin, shift work, and medical and psychiatric disorders. Since many causes of sleepiness are difficult to differentiate from each other, and treatment modalities can vary greatly from one disorder to another, this book helps the clinician to formulate a differential diagnosis that will ultimately lead to the correct diagnosis. Epidemiology, evaluation of the sleepy patient, diagnostic investigations including neuroimaging, subjective and objective testing, cognitive effects of sleepiness, motor vehicle driving issues, medico-legal aspects of sleepiness, and therapy are also discussed in detail. This is an essential resource for neurologists, psychiatrists and sleep specialists. Michael J. Thorpy, Michel Billiard Contents Preface; Foreword Tom Roth; 1. Epidemiology of sleepiness Maurice M. Ohayon; 2. Neurochemistry of excessive sleepiness Nishino Seihi and Okuro Masashi; 3. Functional neuroimaging of disorders of sleepiness Eric A. Nofzinger; 4. The clinical evaluation of patients with excessive sleepiness Imran Ahmed and Michael J. Thorpy; 5. Clinical objective measures of excessive sleepiness Michael H. Bonnet and Donna Arand; 6. Subjective measures of sleepiness Chris L. Drake; 7. Cognitive effects of sleepiness Hans P. Van Dongen; 8. Motor vehicle driving and excessive sleepiness Anna Anund and Goran Keckland; 9. Medico-legal consequences of excessive sleepiness Charles F. George; 10. Sleep deprivation David F. Dinges and Goel Namni; 11. Narcolepsy Gert Jan Lammers; 12. Idiopathic hypersomnia Michel Billiard; 13. Kleine–Levin Syndrome Isabelle Arnulf; 14. Menstrual related hypersomnia Fiona C. Baker; 15. Sleepiness due to sleep related breathing disorders Jean-Louis Pepin; 16. Sleepiness in insomnia Andrew D. Krystal; 17. Delayed and advanced sleep phase syndrome and sleepiness Scott S. Campbell and Patricia Murphy; 18. Shift worker disorder and sleepiness Torbjorn Akderstedt; 19. Sleepiness in health care workers Brian Abaluck and Christopher P. Landrigan; 20. Sleepiness and the military Tom Balkin; 21. Sleepiness and jet lag James Waterhouse; 22. Restless legs syndrome and periodic limb movements Clete A. Kushida; 23. Long sleepers Catherine S. Fichten; 24. Sleepiness in children Sanjeev Kothare and Joseph Kaleyias; 25. Depression and sleepiness Sarah L. Chellappa and Christian Cajochen; 26. Ageing, Alzheimer's disease and sleepiness Sonia Ancoli-Israel and Liat Anyalon; 27. Parkinson's disease and sleepiness David Rye; 28. Myotonic dystrophy and sleepiness Luc Laberge and Yves Dauvilliers; 29. Post-traumatic sleepiness Christian R. Baumann; 30. Genetic disorders and sleepiness Sona Nevsimalova; 31. Brain tumors, infections and other CNA causes of sleepiness Mari Viola-Saltzman and Nate F. Watson; 32. Hypothyroidism and other endocrine causes of sleepiness Hideto Shinno; 33. Toxic and metabolic causes of sleepiness Fabio Cirignotta and Fabio Pizza; 34. Excessive sleepiness due to medications and drugs Paula K. Schweitzer; 35. Amphetamines, methylphenidate and excessive sleepiness Una D. McCann; 36. Modafinil and armodafinil and excessive sleepiness Renee Monderer and Michael J. Thorpy; 37. Sodium oxybate and excessive sleepiness Neil Feldman; 38. Caffeine and other alerting agents William D. Killgore; 39. H3 antagonists, hypocretin agonists and other novel alerting agents Christian Guilleminault and Meredith Broderick; 40. Behavioral and psychiatric treatment of sleepiness Shelby Harris and Michael J. Thorpy; Index.