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Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment. Features • Draws together the available research on microbleeds into one accessible volume • Easy access to all relevant research with authoritative information and discussion • Systematically covers all aspects from pathology to clinical practice Table of Contents Preface Foreword Vladimir Hachinski A short note on terminology Part I. Historical Aspects, Detection and Interpretation: 1. Historical overview: microaneurysms, cerebral microbleeds and intracerebral hemorrhage Varinder Singh Alg and David J. Werring 2. Detection of microbleeds – physical principles, technical aspects and new developments Maarten J. Versluis, Andrew G. Webb and Mark A. van Buchem 3. Susceptibility-weighted imaging E. Mark Haacke, Alexander S. Boikov, Samuel Barnes, Jaladhar Neelavalli and M. Ayaz Khan 4. Defining and mapping cerebral microbleeds Simone M. Gregoire and David J. Werring 5. Microbleed mimics Neshika Samarasekera, Gillian Potter and Rustam Al-Shahi Salman Part II. Mechanisms Underlying Microbleeds: 6. Histopathology of cerebral microbleeds Sebastian Brandner 7. Risk factors for cerebral microbleeds Lenore J. Launer 8. Relationship of cerebral microbleeds to other imaging findings Eric E. Smith, David J. Werring and Cheryl R. McCreary Part III. Microbleeds in Relation to Specific Populations, Diseases and Neurological Symptoms: 9. Microbleeds in healthy populations Bo Norrving 10. Microbleeds in relation to cerebrovascular disease Seung-Hoon Lee and Jae-Kyu Roh 11. Microbleeds in relation to hypertensive arteriopathy Eric E. Smith and Roland N. Auer 12. Microbleeds in relation to cerebral amyloid angiopathy M. Ayaz Khan, Anand Viswanathan and Steven M. Greenberg 13. Cerebral microbleeds and Alzheimer's disease Charlotte Cordonnier and Wiesje M. van der Flier 14. Cerebral microbleeds in relation to brain trauma Rainer Scheid 15. Cerebral microbleeds in CADASIL Anand Viswanathan, Hugues Chabriat and Martin Dichgans 16. Miscellaneous conditions associated with cerebral microbleeds David J. Werring and Hans Rolf Jäger 17. Cerebral microbleeds and cognitive impairment David J. Werring and Mike O'Sullivan 18. Other clinical manifestations of cerebral microbleeds Simone M. Gregoire and David J. Werring 19. Cerebral microbleeds and antithrombotic treatment Yannie O. Y. Soo and Lawrence K. S. Wong 20. Cerebral microbleeds and thrombolysis Chelsea S. Kidwell Index.