The human urinary bladder is subject to a unique and extraordinarily diverse array of congenital, inflammatory, metaplastic, and neoplastic abnormalities. This book provides contemporary, comprehensive, and evidence-based practice information for pathologists, urologists, oncologists, and other medical professionals. In Bladder Pathology, a full spectrum of pathologic conditions that afflict the bladder and urothelium are described and lavishly illustrated. With its emphasis on diagnostic criteria and differential diagnoses, this book is of particular value to practicing pathologists—assisting in the pathologist’s recognition, understanding, and accurate interpretation of the light microscopic findings in bladder specimens. Features and benefits of this new volume include: • 1,741 high-quality, color illustrations and 112 tables to illustrate the wide range of pathologic and clinical features in the urinary tract • An evidence-based approach to diagnosis and patient management for infectious, nonneoplastic, and neoplastic conditions • Recent advances in the molecular genetics of the urinary bladder with discussion of their current or potential impact on diagnosis and personalized patient care • With emphasis on the scientific validation of current diagnostic methods and their direct application in clinical practice, Bladder Pathology is a cutting-edge resource that not only offers comprehensive research and clinical information for practicing surgical pathologists, urologists, oncologists, and their clinical colleagues, but also captures a genuine sense of excitement about recent advances in this vital, ever-evolving field. CONTENTS 1. Normal Anatomy and Histology 2. Inflammatory and Infectious Conditions 3. Urothelial Metaplasia and Hyperplasia 4. Polys and Other Non-Neoplastic Benign Conditions 5. Benign Epithelial Tumors 6. Flat Urothelial Lesions with Atypia and Urothelial Dysplasia 7. Urothelial Carcinoma in Situ 8. Bladder Cancer: General Features 9. Grading of Bladder Cancer 10. State pT1 Urothelial Carcinoma 11. Staging of Bladder Cancer 12. Histologic Variants of Urothelial Carcinoma 13. Adenocarcinoma and Its Putative Precursors and Variants 14. Squamous Cell Carcinoma and Other Squamous Lesions 15. Neuroendocrine Tumors 16. Sarcomatoid Carcinoma (Carcinosarcoma) 17. Bladder Tumors with Inverted Growth 18. Congenital Disorders and Pediatric Pathology 19. Soft Tissue Tumors 20. Lymphoid and Hematopoeitic Tumors 21. Urothelial Carcinoma Following Augmentation Cystoplasty 22. Other Rare Tumors 23. Secondary Tumors 24. Treatment Effects 25. Handling and Reporting of Bladder Specimens 26. Diagnostic Immunohistochemistry 27. Pathology of the Urachus 28. Pathology of Renal Pelvis, Ureter, and Urethra 29. Molecular Determinants of Tumor Recurrence 30. Urinary Cytology 31. Evaluation of Hematuria and Urianalysis 32. Urine Based Biomarkers 33. Tissue Based Biomarkers 34. Molecular Pathology of Bladder Cancer.