Diastology

Accounting for more than 40% of all heart failure problems, diastolic heart failure is a complex and often difficult diagnosis with rapidly evolving diagnostic management protocols. Diastology: Clinical Approach to Heart Failure with Preserved Ejection Fraction, 2nd Edition, brings you up to date and equips you to successfully diagnose and manage even the most challenging incidences of diastolic heart failure and their comorbidities. It incorporates the latest guidelines for the diagnostic evaluation of the patient with suspected or known diastolic dysfunction, provides a comprehensive review of clinical conditions associated with heart failure with preserved ejection fraction, and describes the complementary role of imaging modalities and novel therapeutic approaches.

Table of Contents:

Part I: Basic Determinants of Diastolic Function

    Molecular, Gene, and Cellular Mechanis

    Pathophysiology of Heart Failure With a Preserved Ejection Fraction: Measurements and Mechanisms Causing Abnormal Diastolic Function

    Role of the Pericardium in Diastolic Dysfunction

    Left Atrial Function: Basic Physiology

    Physical Determinants of Diastolic Flow

    Ventricular–Arterial Interaction in Patients With Heart Failure and a Preserved Ejection Fraction

    Part II: Diagnosis of Heart Failure With Preserved Ejection Fraction

    General Principles, Clinical Definition, Epidemiology, and Pathophysiology

    Invasive Hemodynamic Assessment in Heart Failure With Preserved Ejection Fraction

    Two-Dimensional and Doppler Evaluation of Left Ventricular Filling, Including Pulmonary Venous Flow Velocity

    Evaluation of Diastolic Function by Tissue Doppler, Strain, and Torsion Analysis

    Color M-mode Doppler

    Assessment of Left Atrial Size and Function

    Evaluation of Intracardiac Filling Pressures

    Evaluation of Right Ventricular Diastolic Function

    Evaluation of Diastolic Function by Cardiac Magnetic Resonance Imaging

    Evaluation of Diastolic Function by Radionuclide Techniques

    Diastolic Echocardiographic Examination

    Diastology Stress Test

    ASE/EACVI Diastolic Guidelines: Strength and Limitations

    Part III: Cardiac Diseases With HFpEF

    Hypertension and Its Relation to Heart Failure With a Preserved Ejection Fraction

    Valve Disease

    Stage D Heart Failure With Preserved Ejection Fraction, Heart Transplantation, and Mechanical Circulatory Support

    Primary Restrictive, Infiltrative, and Storage Cardiomyopathies

    Coronary Artery Disease

    Hypertrophic Cardiomyopathy

    Pericardial Diseases: Constrictive Pericarditis and Pericardial Effusion

    Diastolic Function in Children and in Children With Congenital Heart Disease

    Diabetes Mellitus

    Part IV: Emerging Topics in HFpEF

    Global and Regional Systolic Function of the Left Ventricle

    Chronotropic Incompetence and Pacing in HPEF Heart Failure with Preserved Ejection Fraction

    Aging and Heart Failure With Preserved Ejection Fraction

    Perioperative Assessment of Diastolic Function

    Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

    Part V: Treatment of HFpEF

    General Treatment of Heart Failure With Preserved Ejection Fraction and Randomized Trials

    Echo-Based Approach to the Management of Heart Failure With Preserved Ejection Fraction

    Future Therapies in HFpEF

    Part VI: Cases of Diastolic Heart Failure

    Cases of Diastolic Heart Failure