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This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment. Randi Hagerman, Distinguished Professor of Pediatrics, UC Davis M.I.N.D. Institute, and Robert Hendren, Professor and Vice Chair, Director, Child and Adolescent Psychiatry, University of California, San Francisco CONTENTS Chapter 1 Overview of Neurodevelopmental Processes and the Assessment of Patients with Neurodevelopmental Disorders Robert Hendren, Andre Goldani, Randi Hagerman Chapter 2 Autism: Neurobiologic Mechanisms and Targeted Treatments Robert Hendren and Randi Hagerman Chapter 3 Targeted Treatments in Schizophrenia Danielle A. Schlosser, Coleman Garrett, Sophia Vinogradov Chapter 4 Neurodevelopmental and Neurobiological Aspects of Major Depressive Disorder: From Theory to Therapy Blake Rawdin, Daniel Lindqvist, Nicole Bush, Steven Hamilton, Ruhel Boparai, Scott Mackin, Victor I. Reus, Synthia H. Mellon, Owen M. Wolkowitz Chapter 5 Attention Deficit Hyperactivity Disorder Kyle J. Rutledge, Khyati Brahmbhatt, Julie Schweitzer Chapter 6 Targeted Treatments in Rett Syndrome Daniel C. Tarquinio, Walter E. Kaufmann Chapter 7 Cardio-facio-cutaneous Syndrome and other RASopathies: Prospects for Treatment William E. Tidyman and Katherine A. Rauen Chapter 8 Targeted Treatments in Tuberous Sclerosis Complex (TSC) Petrus J de Vries Chapter 9 Treatment of Fragile X syndrome and Fragile X-associated Disorders Reymundo Lozano, Emma B. Hare, Randi J. Hagerman Chapter 10 Angelman Syndrome Mary Jacena Leigh, Lindsey Partington, Edwin Weeber Chapter 11 Pharmacotherapy for Cognitive Enhancement in Down Syndrome Aarti Ruparelia, David Patterson, William C. Mobley Chapter 12 Targeted Treatments for Phenylketonuria Billur Moghaddam Chapter 13 Muscular Dystrophies: Diagnosis and New Treatments Bethany M Lipa, Que T. Nguyen, Jay J. Han Chapter 14 Translating Treatments from the Laboratory to the Clinic Randi Hagerman, Billur Mogahadam, Jan Nolta, Maria Diez, Robert Hendren Index
Oxford University Press
August 28, 2014
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