Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineral metabolism. This has lead to the development of new treatment strategies and agents. This new second edition reflects the most current thinking and understanding in this fascinating field, as presented by world basic and clinical experts. A comprehensive guide to the impact of chronic kidney disease on the skeleton Fully-updated to include new treatment agents and strategies to manage both conditions simultaneously Reflects new understanding of the relation of renal bone disease and cardiovascular disease In full colour throughout, including numerous colour illustrations New to this edition Now in full colour throughout Reflects new understanding of the relation of renal bone disease and cardiovascular disease Klaus Olgaard , Professor of Nephrology, Rigshospitalet and University of Copenhagen, Denmark, Justin Silver , Professor of Medicine, Chief of Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel, and Isidro B. Salusky , Professor of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, USA CONTENTS 1: Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD) 2: New aspects of normal bone biology 3: Osteocytes and mineral metabolism 4: Calcium-sensing receptors (CaSRs) in kidney, bone and vessels 5: Regulation of parathyroid hormone biosynthesis and gene expression 6: Abnormal parathyroid gland function in CKD 7: PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor 8: Vitamin D metabolism and action in CKD 9: Growth factors and cytokines in renal bone disease 10: Bone histomorphometry in renal osteodystrophy 11: The spectrum of renal osteodystrophy and vascular calcifications in uremia 12: Imaging of the skeleton and the joints in CKD 13: Non-invasive assessment of vascular calcification and arterial stiffness 14: Osteopenia in uremia 15: Acidosis and renal bone disease 16: Dialysis-associated amyloidosis 17: Pathogenesis of vascular calcification: experimental studies 18: Clinical consequences of arterial calcifications and soft-tissue calcifications in Chronic Kidney Disease 19: Clinical management of vascular and soft tissue calcifications in Chronic Kidney Disease patients 20: The role of the skeleton in the pathogenesis of vascular calcification in the Chronic Kidney Disease-Mineral Bone Disorder 21: Klotho: bone, kidney, vascular calcifications, and the ageing process 22: Physiology and pathology of calcium and magnesium transport 23: Phosphatonins in health and disease 24: FGF-23 in renal failure 25: New vitamin D analogs for chronic kidney disease patients 26: Calcimimetics and calcilytics in the treatment of chronic kidney disease-mineral and bone disorder 27: Medical therapy in chronic kidney disease 28: Chronic kidney disease-mineral and bone disorder (CKD-MBD) in children 29: Bone disease in renal transplant recipients 30: Imaging and intervention of parathyroid hyperplasia 31: Surgical management of secondary hyperparathyroidism 32: Morbidity and mortality related to disturbances in mineral metabolism in CKD
