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This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflamation, immunopathology, vascular disturbance, and tumor biology. Guido Majno, Professor, and Isabelle Joris, Associate Professor, both at the Department of Pathology, University of Massachusetts Medical Center Contents Introduction PART I: CELLULAR PATHOLOGY 1 The long road to the elementary patient 2 Cellular adaptations 3 Symptoms of cellular disease: Intracellular accumulations 4 Pathology of the organelles 5 Cell injury and cell death 6 Pathologic calcification 7 Extracellular pathology PART II: INFLAMMATION 8 Introduction to inflammation 9 Inflammation: The actors and their language 10 The four cardinal signs of inflammation 11 Leukocytes called to action: Steps to Phagocytosis 12 The inflammatory exudate 13 Chronic inflammation 14 Wound healing 15 General effects of local injury and inflammation 16 Variations and aberrations of the inflammatory response PART III: IMMUNOPATHOLOGY 17 Hypersensitivity reactions 18 Pathology of transplantation 19 Autoimmune disease 20 Immunosuppression 21 Disturbances of fluid exchange 22 Hemostasis and thrombosis 23 Obstacles to blood flow 24 Ischemia and shock PART V: TUMORS 25 Tumors: Names and personalities 26 Anatomy and biology of tumors 27 Tumor aggression 28 The causes of tumors 29 Genes and tumors 30 Antitumor defenses 31 The reversability of tumors 32 Epidemiology of cancer 33 What is a tumor? 34 Tumors as a clinical problem