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Content
This two-volume set provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine. Huntington Ph.D Willard, Institute for Genome Sciences & Policy, Duke University, Durham, NC, USA and Geoffrey S. Ginsburg, Institute for Genome Sciences & Policy, Duke University, Durham, NC, USA Table of Contents: Part I. Genome-Based Approaches to Biology and Medicine Principles of Human Genomics 1. Organization, Variation and Expression of the Human Genome 2. Mapping the Funcational Genome: The ENCODE and Roadmap Epigenomics Projects 3. Population Perspectives on Genome Variation and Complex Disease 4. Gene-Environment Interactions: Eco-genetics and Toxicogenomics 5. Systems Biology and Systems Medicine Genome-Based Approaches for Genomic and Personalized Medicine 6. Personal Genomics 7. Whole genome sequencing: new technologies, approaches, applications 8. Human Genome Variation Discovery via Exome and Whole-Genome Sequencing 9. Clinical Genome Sequencing 10. Structural Genomic Variation in the Human Genome 11. Clinical applications of whole-genome chromosomal microarray analysis 12. Transcriptomics in the age of ultra high-throughput sequencing 13. Quantitative Proteomics in Genomic Medicine 14. The Human Microbiome and Personalized Medicine 15. Glycomics, glycobiology, glycomedicine 16. Genome-wide RNA Interference Screening Part II. Translational Approaches in Genomic and Personalized Medicine Enabling Genomic Strategies, Clinical Research, and Informatics Platforms for Genomic and Personalized Medicine 17. Application of Human Genome Information to Clinical Practice 18. Genomic and Personalized Medicine and Public Health View 19. Biospecimen Banking in the Post Genome Era 20. Designing Genome-Based Clinical Studies 21. Genomic Biomarkers in Human Population Studies 22. Validating Candidate Protein Biomarkers 23. Translational Bioinformatics for Genomic Medicine 24. Electronic Health Records and Genomic Medicine 25. Clinical Implementation of Genomic Medicine in Primary Care 26. Health Risk Assessment and Family History 27. Clinical Decision Support 28. Knowledge Management in Personalized Health Care 29. Integration into Healthcare Systems 30. Pharmacogenomics in Drug Discovery and Development 31. Pharmacogenetics and Pharmacogenomics 32. Point of Care Devices 33. Patient-specific Pluripotent Stem Cells Policy Challenges in Genomic and Personalized Medicine 34. Overview of Policy, Ethical and Social Considerations 35. Informed Consent 36. Educational Issues and Strategies for Genomic Medicine 37. Regulation of Genomic Technologies 38. Challenges and Regulation of Direct to Consumer Genetic Testing 39. Economics of Genomic Medicine 40. trategies in the Adoption of Genome-Based Diagnositics 41. Reimbursement 42. Impact of Patents on Genomic Medicine 43. Public-Private Partnerships in Biomarker Discovery and Development Part III. Disease-Based Genomic and Personalized Medicine: Genome Discoveries & Clinical Significance Cardiovascular Genomic Medicine 44. Hypertension 45. Lipoprotein Disorders 46. Coronary Artery Disease and Myocardial Infarction 47. The Vulnerable Plaque and Acute Coronary Syndromes 48. Heart Failure 49. Cardiac Transplant Rejection 50. Hypertrophic Cardiomypoathies 51. Arrhythmias 52. Hemostasis and Thrombosis 53. Peripheral Afterial Disease 54. Congenital Heart Disease 55. Perioperative Genomics 56. Stroke Oncology Genomic Medicine 57. Lymphomas 58. Leukemias 59. Genomics of Lung Cancer 60. Breast Cancer 61. Ovarian Cancer 62. Colorectal Cancer 63. Prostate Cancer 64. Head and Neck Cancer 65. Brain Tumors and Gilomas 66. Melanoma 67. Metastatic Cancer 68. Bioinformatics and Personalized Cancer Care 69. Diagnostic-Therapeutic Combinations Inflammatory and Metabolic Disease Genomic Medicine 70. Autoimmune Disorders 71. Rheumatoid Arthritis 72. Multiple Sclerosis 73. Inflammatory Bowel Disease 74. Asthma 75. Chronic Obstructive Pulmonary Disease 76. Interstitial Lung Disease 77. Peptic Ulcer Disease 78. Cirrhosis 79. System Sclerosis 80. Lupus 81. Osteoarthritis 82. Diabetes Genomics 83. The Metabolic Syndrome Neuropsychiatric Disease Genomic Medicine 84. Overview of Neuroscience and Genomics 85. Alzheimers Disease 86. Parkinson's Disease 87. Epilepsy 88. Schizophrenia and Bipolar Disorder 89. Depression 90. Autism 91. Overview of Eye Disease and Genomics 92. Glaucoma Infectious Disease Genomic Medicine 93. Diagnosis and Classification of Pathogens 94. Host-Pathogen Interactions 95. Microbial Vaccine Development 96. Bacterial Infections 97. Emerging Viral Infections 98. Sepsis 99. Viral Hepatitis 100. Malaria 101. HIV Pharmacogenetics and Pharmacogenomics
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