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Significant advances in our knowledge of genetics were made during the twentieth century but in the most recent decades, genetic research has dramatically increased its impact throughout society. Genetic issues are now playing a large role in health and public policy, and new knowledge in this field will continue to have significant implications for individuals and society. Written to communicate sound and modern science in an an accessible way for all, Human Genetics, 3E will increase the genetics knowledge of researcher, practitioners, and students alike who are learning about human genetics for the first time. This thorough revision of the best-selling Human Genome,2E includes entirely new chapters on forensics, stem cell biology, bioinformatics, and societal/ethical issues associated with the field. New special features boxes make connections between human genetics and human health and disease. Carefully crafted pedagogy to support self-learning and the use of the book in classroom setting includes chapter-opening case studies that set the stage for each chapter; concept statements interspersed throughout chapters to keep focus on key concepts; and end-of-chapter questions and critical thinking activities. This new edition will contribute to creating a genetically literate research population that understands elements of the personal and health implications of genetics and participates effectively in public policy issues involving genetic information. - Includes more topical material--e.g., forensics, stem cells, human genome project--to draw the non-specialist student into the material - Interest boxes that focus on human health and disease gives the non-specialist reader a context in which to understand the material-i.e.,why is this important to me? - Full ancillary package, including Instructor's Manual,e-transparencies, test bank, companion Website with student self-tests - Expert authorship by Scott Hawley, of the Stower's Institute for Medical Research, and 2008 recipient of excellence in teaching award from the Genetics Society of America; Julia Roberts Julia Richards, University of Michigan, Ann Arbor, MI - R. Scott Hawley, Stowers Institute for Medical Research, Kansas City, MO Contents Section I: HOW GENES SPECIFY A TRAIT 1 The Basics of Heredity: How Traits Are Passed Along in Families 2 The Double Helix: How Cells Preserve Genetic Information Section II: HOW GENES FUNCTION 3 The Central Dogma of Molecular Biology: How Cells Orchestrate the Use of Genetic Information 4 We Are All Mutants: How Mutation Alters Function SECTION III HOW CHROMOSOMES MOVE 5 Mitosis and Meiosis: How Cells Move Your Genes Around 6 The Odd Couple: How the X and Y Chromosomes Break the Rules SECTION IV. HOW GENES CONTRIBUTE TO COMPLEX TRAITS 7 Sex Determination: How Genes Determine a Developmental Choice 8 Complexity: How Traits Can Result from Combinations of Factors 9 Genes Are Not Destiny: How Environment Modulates Genotype 10 The Multiple-Hit Hypothesis: How Genes Play a Role in Cancer SECTION V: HOW GENES ARE FOUND 11 The Gene Hunt: How We Map the Locations of Genes 12 The Gene Hunt: How We Find Genes We Have Mapped SECTION VI: HOW GENES PLAY A ROLE IN TESTING AND TREATMENT 13 Genetic Testing and Screening: How We Apply Mutation Screening to Human Families and Individuals 14 Magic Bullets: How Gene Therapy Personalizes Medicine 15 Fears, Faith, and Fantasies: How the Past and the Present Shape the Future of Genomic Medicine