Since the first edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of translational research and the “from bench to bedside” concept, much progress from the lab has been applied to clinical practice. Additionally, several highly relevant clinical trials published over the last decade have resulted in the updating and optimisation of clinical guidelines.
A new and validated classification of the severity and complications of acute pancreatitis that is firmly rooted in clinical practice has become the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Increased study of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years, is especially important. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. Updates based on these developments and more are included in the new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons.
This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons is a result of the collaboration between the world's leading experts in each area of clinical pancreatology, with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their daily clinical practice. This book is an indispensable update providing leading knowledge in clinical pancreatology.
Contents
Contributors
Foreword
Preface
Dedication
1 Acute pancreatitis: An overview
Jodie A. Barkin, Jamie S. Barkin
2 How to deal with the etiological diagnosis of acute pancreatitis in clinical practice
Soumya Jagannath, Pramod Kumar Garg
3 Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice
David X. Jin, Peter A. Banks, Julia McNabb-Baltar
4 Early prediction of severity in acute pancreatitis: What can be done in clinical practice?
Peter J Lee, Georgios I Papachristou
5 Role of CT Scan in Acute Pancreatitis: When is it Indicated and What Information can be Obtained?
Elham Afghani, Mahya Faghih, Vikesh Singh
6 Role of MRI in acute pancreatitis. When is it indicated and what information can be obtained?
Fatih Akisik
7 Treatment of acute pancreatitis in the emergency room: What should be done during the first hours of disease?
Thiruvengadam Muniraj and Santhi Swaroop Vege
8 Acute pancreatitis: A practical guideline for the monitoring and treatment of systemic complications
Enrique de-Madaria and Felix Zubia-Olaskoaga
9 Guidelines for the treatment of pain in acute pancreatitis
László Czakó
10 Nutrition in the acute phase of pancreatitis: Why, when, how and how long?
Angela Pham and Chris E Forsmark
11 Oral refeeding in acute pancreatitis: When and how should it be restarted?
José Lariño-Noia, Daniel de la Iglesia-García
12 Pharmacological therapy for acute pancreatitis: any light at the end of the tunnel?
Rajarshi Mukherjee, Muhammad Awais, Wenhao Cai, Wei Huang, Peter Szatmary, Robert Sutton
13 Indication and optimal timing of ERCP in acute pancreatitis
Theodor Voiosu, Ivo Boškoski, Guido Costamagna
14 How to deal with infected pancreatic necrosis?
J. Enrique Domínguez Muñoz
15. Minimally invasive surgical necrosectomy in clinical practice: Indications, technical issues and optimal timing.
Patricia Sánchez-Velázquez, Fernando Burdío, Ignasi Poves
16 Endoscopic Necrosectomy in Clinical Practice: Indications, Technical issues and Optimal Timing
Jodie A Barkin, and Andres Gelrud
17 MANAGEMENT OF ACUTE PANCREATIC PSEUDOCYST: WHEN TO OBSERVE, WHEN AND HOW TO DRAIN
Muhammad F. Dawwas, Kofi W. Oppong
18 The disconnected main pancreatic duct syndrome: How to proceed with it in clinical practice?
Mario Peláez-Luna, Andrea Soriano-Ríos, Luis Uscanga-Dominguez
19 Vasculature Complications in Pancreatitis: How to Deal with Them?
Daniel G. McCall and Timothy B. Gardner
20 Acute relapsing pancreatitis: What can be done to prevent relapses?
Jorge D. Machicado, Dhiraj Yadav
21 Diagnosis and therapeutic approach to pancreatic exocrine insufficiency after acute pancreatitis
H.C. Timmerhuis, C. J. Sperna Weiland, H.C. van Santvoort
22 Asymptomatic chronic elevation of serum pancreatic enzymes: How to deal with it?
Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso
23 Definition and etiology of chronic pancreatitis: What is relevant for clinical practice?
David C. Whitcomb
24 Epidemiology of chronic pancreatitis: An infrequent disease or an infrequently diagnosed disease?
Philippe Lévy, Vinciane Rebours
25 Alcoholic chronic pancreatitis and the impact of alcohol and smoking cessation in chronic pancreatitis
JS Wilson, RC Pirola, MV Apte
26 What is relevant on genetics in chronic pancreatitis for clinical practice? What genes and when to evaluate them?
Jonas Rosendahl
27 Pancreas divisum and other potential obstructive causes of chronic pancreatitis (When and how to treat them?)
Matthew J. DiMagno, Erik-Jan Wamsteker
28 What to do in clinical practice before defining a chronic pancreatitis as idiopathic? A practical protocol
Felix Lämmerhirt, Frank Ulrich Weiss, Markus M. Lerch
29 CT for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice
Roberto García-Figueiras, Sandra Baleato-González, Gonzalo Tardáguila de la Fuente
30 Role of MRI and MRCP for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice.
Jordan K. Swensson, Temel Tirkes
31 Role of endoscopic ultrasound and associated methods (elastography, contrast enhancement) for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice.
Julio Iglesias-Garcia
32 Endoscopic pancreatic function test for the functional diagnosis of chronic pancreatitis: indications and practical protocol
Luis F. Lara, Darwin L. Conwell
33 Role of pancreatic function tests for the diagnosis of chronic pancreatitis: Which tests and how should they be performed in clinical practice?
J. Enrique Domínguez Muñoz
34 Follow-up of patients with chronic pancreatitis in clinical practice: How and what for?
Antonio Mendoza Ladd, Luis F. Lara, Darwin L. Conwell
35 QUALITY OF LIFE IN CHRONIC PANCREATITIS
Colin D Johnson
36 Medical treatment of pain in chronic pancreatitis: Guidelines for clinical practice
Asbjørn Mohr Drewes, Louise Kuhlman, Trine Andresen & Søren Schou Olesen
37 Endoscopic treatment of pain in chronic pancreatitis:
Indications, optimal timing and technical aspects
P.M.C. Stassen, P.J.F. de Jonge, J.W. Poley, D.L. Cahen, M.J. Bruno
38 Diagnosis and management of pancreatic exocrine insufficiency in chronic pancreatitis: A practical protocol
J. Enrique Domínguez-Muñoz
39 Surgical treatment of pain in chronic pancreatitis: indications, optimal timing and technical approaches
Benjamin PT Loveday, John A Windsor
40 Management of chronic pancreatic pseudocyst: when to observe, when and how to drain?
Shyam Varadarajulu
41 Vascular complications in chronic pancreatitis
Anil K Agarwal, Raja Kalayarasan, Amit Javed
42 SURGICAL THERAPY OF LOCAL COMPLICATIONS OF CHRONIC PANCREATITIS: INDICATIONS, TECHNICAL APPROACHES AND OPTIMAL TIMING
Ricardo Arvizu Castillo, Elena Muñoz-Forner, Luis Sabater
43 Endoscopic treatment of complications of chronic pancreatitis other than pseudocyst
Jahangeer Basha, Rupjyoti Talukdar, D. Nageshwar Reddy.
44 Autoimmune pancreatitis: Definition, clinical presentation and classification.
Miroslav Vujasinovic and J.-Matthias Löhr
45 Diagnosis of Autoimmune Pancreatitis: a Protocol for Clinical Practice
Nicolò de Pretis , Antonio Amodio and Luca Frulloni
46 Treatment and follow-up of autoimmune pancreatitis in clinical practice
Sushil Kumar Garg, Suresh T Chari
47 CFTR-associated pancreatic disease: genotype-phenotype correlations and impact of CFTR-modifying therapy
Aimee Joy Wiseman and Chee Y. Ooi
48: Nutritional therapy, pancreatic exocrine insufficiency, and pancreatic enzyme replacement therapy in cystic fibrosis: a protocol for clinical practice
Jefferson N. Brownell, Laura Padula, Elizabeth Reid, Virginia A. Stallings, Asim Maqbool,
49 EPIDEMIOLOGICAL IMPACT OF PANCREATIC CANCER
Patrick Maisonneuve
50 Molecular and genetic basis of pancreatic carcinogenesis: Which concepts are clinically relevant?
Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, Helmut Friess
51 New-onset diabetes as a harbinger of pancreatic cancer:
Is early diagnosis possible?
Dana K. Andersen, Suresh T. Chari, Eithne Costello, Tatjana Crnogorac-Jurcevic, Phil A. Hart, Anirban Maitra, Stephen J. Pandol
52 Pancreatic cancer screening: Target populations, methods and protocols for clinical practice
Christopher Paiji, Anne Marie Lennon, Elham Afghani
53 Clinical usefulness of biological markers in pancreatic cancer
David Anz, Ignazio Piseddu, Marlies Köpke, Ujjwal M. Mahajan, Julia Mayerle
54 Staging classification and stratification of pancreatic cancer for clinical practice
Akhil Chawla and Andrew J. Aguirre, MD, PhD
55 Imaging diagnosis and staging of pancreatic cancer: Which methods are essential and what information should they provide?
Megan H. Lee, Elliot K. Fishman
56 THE ROLE OF ENDOSCOPIC ULTRASOUND AND ASSOCIATED METHODS (ELASTOGRAPHY, CONTRAST ENHANCEMENT) IN THE DIAGNOSIS AND ASSESSMENT OF RESECTABILITY OF PANCREATIC CANCER
M. Giovannini
57 EUS-GUIDED FNA/FNB FOR PANCREATIC SOLID LESIONS: WHEN IS IT INDICATED AND WHAT IS THE OPTIMAL TECHNICAL APPROACH?
Mihai Rimbaș, Gianenrico Rizzatti and Alberto Larghi
58 Surgical treatment of resectable pancreatic cancer. What is the optimal strategy?
Jan G. D’Haese, Bernhard W. Renz, Jens Werner
59 Complications after pancreatic surgery. How to deal with them.
Tommaso Giuliani, Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi
60 Neoadjuvant treatment of pancreatic cancer: when and how?
Marta Sandini, Thilo Hackert, Ulla Klaiber, Markus W. Büchler, John P. Neoptolemos
61 Adjuvant therapy in pancreatic cancer : options, safety and outcomes
Jean-Luc Van Laethem
62 Management of pain in pancreatic cancer: An algorithm for clinical routine
J. Enrique Domínguez-Muñoz
63 EUS-guided celiac plexus neurolysis for pain in pancreatic cancer: when and how?
Jonathan M. Wyse, Anand V. Sahai,
64 The role of endoscopy in the management of unresectable pancreatic cancer
Jaimin Amin, Ajaypal Singh, and Irving Waxman
65 Chemotherapy for non-resectable pancreatic cancer
Raquel Fuentes, Juan José Serrano, Mercedes Rodríguez, Alfredo Carrato.
66 Diagnosis and management of pancreatic exocrine insufficiency in pancreatic cancer.
Sarah Powell-Brett, Keith J Roberts
67 Nutrition and Pancreatic Cancer
Mary Phillips, Oonagh Griffin
68 Present and future of local therapies for unresectable pancreatic cancer
Testoni Sabrina Gloria Giulia, Rossi Gemma, Archibugi Livia, Arcidiacono Paolo Giorgio
69 New pharmacological approaches for pancreatic cancer therapy: A light at the end of the tunnel?
Vineet K Gupta, Sulagna Banerjee and Ashok Saluja
70 Histologic classification of pancreatic cystic neoplasms
Giuseppe Zamboni, Anna Pesci
71 Incidental pancreatic cystic lesion: How to deal with it?
Atsushi Oba, Robert J. Torphy, Richard D. Schulick, and Marco Del Chiaro
72 Role of endoscopic ultrasound and endoscopic ultrasound-associated techniques in the diagnosis and differential diagnosis of pancreatic cystic tumors
María-Victoria Alvarez-Sánchez and Bertrand Napoléon
73 The role of multidetector CT, MRI and MRCP in the diagnosis and differential diagnosis of pancreatic cystic neoplasms
Megan H. Lee, Elliot K. Fishman
74 Intraductal papillary mucinous neoplasm (IPMN): When to observe, when to operate and optimal surgical approach
Zhi Ven Fong, Carlos Fernandez-del Castillo
75 Cystic tumours others than IPMN: When to observe, when to operate and optimal surgical approach
John W. Kunstman, James J Farrell
76 Pancreatic cystic tumors: any role for local therapies?
Julio Iglesias-Garcia
77. Diagnosis and treatment of pancreatic neuroendocrine tumours: how to deal with them in clinical practice
Francesca Muffatti, Stefano Partelli, Valentina Andreasi, and Massimo Falconi
78 OTHER LESS FREQUENT PANCREATIC TUMOURS: WHAT SHOULD BE KNOWN ABOUT CLINICAL FEATURES, DIAGNOSIS AND TREATMENT?
Rossana Percario, Paolo Panaccio, Fabio F. di Mola, Pierluigi Di Sebastiano and Tommaso Grottola
79 Diagnosis and therapy of exocrine pancreatic insufficiency after gastric and pancreatic surgery
Raffaele Pezzilli
80 Pancreatic exocrine insufficiency in type 1 and type 2 diabetes mellitus: Lessons from pancreatologists to diabetologists
Philip D Hardt
Chapter 81 Diabetes mellitus related to diseases of the exocrine pancreas (pancreatogenic diabetes): diagnosis and treatment.
David Bradley, Phil A. Hart
Index
