Placental-Fetal Growth Restriction

Master the effective evaluation, analysis and management of placental-fetal growth restriction (PFGR), reducing the risk of perinatal mortality and morbidity in patients worldwide. Extensively researched by international experts, this manual provides practitioners with a detailed, hands-on approach to the practical 'pearls' for direct patient management. This authoritative volume advises on matters such as the correct evaluation and management of high-risk patients in danger of PFGR through to delivery. Extensive and wide-ranging, this book is an invaluable companion to the developing research interest and clinical applications in PFGR, including developmental outcomes in early childhood. Featuring a critical evaluation of a variety of abnormal conditions, such as fetal hypoxia, which are clearly displayed through extensive illustrations. This essential toolkit ensures that practitioners of all levels can effectively limit the risk of mortality and morbidity, and reach the correct diagnosis, first-time.

    Reflects the current research interest and clinical applications in placental-fetal growth restriction (PFGR), worldwide
    Covers the effect of PFGR in the fetus and through to birth and to early childhood
    Authored by an international team of authors with extensive expertise on the topic
    Includes copious illustrations to aid understanding

Table of Contents

Part I. Basic Principles:
1. What is optimal fetal growth? Blanka Vasak and Gerard H. A. Visser
2. Definition of fetal growth restriction and uteroplacental insufficiency Wessel Ganzevoort and Basky Thilaganathan
3. Differential diagnosis of fetal growth restriction S. Usman, A. Lawin-O'Brien and Christoph Lees
4. Fetal growth restriction and hypertensive diseases of pregnancy Christopher W. G. Redman and Anne Cathrine Staff
5. ART and fetal growth Christoph Brezinka and Shirin Khanjani
6. Fetal growth restriction – study design and outcomes Hans Wolf and Wessel Ganzevoort
7. Analysis of national and international guidelines on placental-fetal growth restriction Gemma Malin, Lesley McCowan, K. E. Boers and Jim G. Thornton
Part II. Maternal Cardiovascular Characteristics and the Placenta:
8. Maternal cardiovascular function and fetal growth restriction Rosemary Townsend and Asma Khalil
9. Placental histopathology findings in fetal growth restriction Neil Sebire and William Mifsud
10. Maternal volume homeostasis in fetal growth restriction Johannes J. Duvekot
Part III. Screening for PFGR:
11. First trimester combined screening algorithms for fetal growth restriction Rosemary Townsend and Asma Khalil
12. Second trimester and late pregnancy screening for fetal growth restriction Raffaele Napolitano and Pasquale Martinelli
Part IV. Prophylaxis and Treatment:
13. Prophylaxis for fetal growth restriction: aspirin and low molecular weight heparins Federico Prefumo and Tiziana Frusca
14. Prophylaxis for fetal growth restriction: nitric oxide donors and sildenafil Dietmar Schlembach
15. Prevention and Treatment of Fetal Growth Restriction by influencing maternal hemodynamics and blood volume Herbert Valensise, Barbara Vasopollo and Gian Paolo Novelli
16. Gene therapy in fetal growth restriction Rebecca N. Spencer, David J. Carr and Anna L. David
Part V. Characteristics of Fetal Growth Restriction:
17. Blood flow volume in umbilical vein in fetal growth restriction Enrico Ferrazzi, Daniela Di Martino and Tamara Stampalija
18. Fetal cardiac function in fetal growth restriction Fatima Crispi and Eduard Gratacos
19. Heart rate changes and autonomic nervous system in fetal growth restriction S. M. Lobmaier, K. T. M. Schneider and G. H. A. Visser
20. The fetal arterial and venous circulation in IUGR Kurt Hecher and Werner Diehl
21 Hematological and biochemical findings in fetal growth restriction and the relationship to hypoxia Irene Cetin and Chiara Mandò
Part VI. Management of Fetal Growth Restriction:
22. Management of early-onset fetal growth restriction (less than 34 weeks) Tullia Todros and Giovanna Oggé
23. Late-onset intrauterine growth restriction Katia Bilardo and Francesc Figueras
24. Severe IUGR: pregnancy management at the limits of viability Aris T. Papageorghiou and Wessel Ganzevoort
25. Fetal growth restriction in twin pregnancies Isabel Couck, Kurt Hecher and Liesbeth Lewi
Part VII. Postnatal Aspects of Fetal Growth Restriction:
26. Fetal growth restriction and neonatal outcomes R. S. Gandhi and N. Marlow
27. Fetal growth restriction and later disease in the mother and the offspring Birgit Arabin and Petra Arck
28. Fetal growth restriction: recurrence risks and counseling Jan Derks and Steven Koenen.

Christoph Lees is Reader in Obstetrics and Fetal Medicine at Imperial College London; Honorary Consultant in Obstetrics and Head of Fetal Medicine at Imperial College Healthcare NHS Trust and Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, London.

Gerard H. A. Visser is Emeritus Professor of Obstetrics, Department of Obstetrics and Gynaecology, University of Utrecht Medical Centre, The Netherlands.

Kurt Hecher is Professor and Head, Department of Obstetrics and Fetal Medicine, University Medical Centre, Hamburg, Germany. A previous President of the International Society of Ultrasound in Obstetrics and Gynecology, Hecher is also Deputy Editor-in-Chief of Ultrasound in Obstetrics and Gynecology.