Frontotemporal dementia (FTD) is a cruel disease, robbing patients of core human characteristics and wreaking havoc with relationships. Clinical and scientific interest in FTD and related disorders continues to grow rapidly, with major advances having occurred since this book's last publication. New clinical diagnostic criteria were published in 2011; new pathological discoveries have led to new diagnostic criteria; and major genetic discoveries have been made. This new edition covers these developments, providing the leading resource on FTD, PPA, PSP, CBD, FTD-ALS, and related disorders, now written by a more internationally representative group of authors than before. Providing an in-depth and expert synthesis of the status of our knowledge of FTD and related syndromes, the content includes chapters reviewing clinical, neuropsychiatric, neuropsychological, imaging, and other features of FTD and multidisciplinary approaches to patient management. Essential reading for specialist and generalist neurologists, , psychiatrists, geriatricians, neuropsychologists, neuropathologists, and basic scientists in relevant fields.
Describes numerous scientific advances in FTD research from the past decade, assisting clinicians in developing an up-to-date framework for treating patients
Offers a resource for understanding clinical as well as pathological and genetic features of frontotemporal dementia syndromes and related diseases, covering the most up-to-date clinical diagnostic and pathological criteria, and recent genetic discoveries
Provides practical suggestions on treatment, management, and resources to assist in the development of care plans
Contents
List of contributors
Editor biographies
Foreword Bruce Miller
Preface
Part I. Introduction to and Brief History of FTD:
1. Historical introduction to FTD John Hodges
2. Overview of the relationship of FTD to other neurodegenerative diseases Paul McMonagle and Andrew Kertesz
Part II. Clinical Phenotypes:
3. Overview of FTD and the variety of its clinical presentations Matthew Jones and David Neary
4. Behavioral variant FTD Katya Rascovsky
5. Primary Progressive Aphasia Chiara Cerami and Stefano F. Cappa
6. The FTD-ALS spectrum Thomas H. Bak and Sharon Abrahams
7. CBS/PSP Barbara Borroni and Antonella Alberici
Part III. Approach to the Diagnosis of FTD:
8. Overview of clinical assessment of frontotemporal dementia syndromes Bradford C. Dickerson, Simon Ducharme and Chiadi U. Onyike
9. Neuropsychological assessment of FTD Teresa Torralva, Macarena Martinez Cuitiño and Facundo Manes
10. Imaging of FTD Jonathan D. Rohrer
11. Biomarkers of FTD Nicolaas A. Verwey, Yolande A. L. Pijnenburg and Philip Scheltens
12. Genetic counseling and testing Jill S. Goldman and Elizabeth McCarty Wood
Part IV. Pathology and Pathophysiology:
13. Neuropathology of FTD and related disorders Manuela Neumann, Gabor G. Kovacs and Ian R. A. Mackenzie
14. Genetics of frontotemporal dementia and related disorders Marc Cruts and Christine Van Broeckhoven
15. Pathophysiology and animal models of FTD Brian A. Warmus and Erik D. Roberson
Part V. Treatment:
16. The impact of FTD on daily life Claire O'Connor and Eneida Mioshi
17. Practical management of FTD Ted Huey and Masood Manoochehri
18. Current and future pharmacologic therapy of FTD and related disorders Richard M. Tsai and Adam L. Boxer
19. Grassroots advocacy and patient/family education and support in FTD Susan Dickinson and Jill Shapira
Index.
