Bipolar Disorders

Over the past two decades, driven by the enormous public health importance of bipolar disorder, research initiatives have begun to elucidate the pathophysiology of this prevalent and debilitating condition. These research initiatives have led to breakthroughs in our understanding of causation, and now promise to foster the development of novel treatments. This new edition presents contributions from the leaders at the forefront of these areas of research, and includes chapters on the groundbreaking advances in the fields of genetics, neuroimaging, neuropsychopharmacology, oxidative stress and neuronal resilience, inflammatory mechanisms, psychosocial factors, childhood onset and late-life bipolar disorder, and many other important areas. Throughout, the therapeutic implications and potential of this new understanding are emphasized. This will be essential reading for those interested in the neurobiology of mental illness, and will be of interest to mental health practitioners more generally.

    Presents contributions from the leaders at the forefront of areas of research into the pathophysiology of bipolar disorder
    Includes chapters on groundbreaking advances in the fields of genetics, neuroimaging, neuropsychopharmacology, oxidative stress and neuronal resilience, inflammatory mechanisms, psychosocial factors, childhood onset and late-life bipolar disorder, and several other areas
    Emphasizes the therapeutic implications and potential of this new understanding

Table of Contents

List of contributors
Preface
1. The classification of bipolar disorders: implications for clinical research Michael J. Ostacher, Mark A. Frye and Trisha Suppes
2. Prospects for the development of animal models for the study of bipolar disorder Trevor R. Norman
3. Abnormalities in catecholamines and the pathophysiology of bipolar disorder Alexander W. Charney, Sehrish Sayed and Dennis S. Charney
4. Serotonergic dysfunction in bipolar disorder Martin J. Lan and J. John Mann
5. Involvement of GABAergic/glutamatergic pathways in mood disorders Paul Stokes and James Stone
6. Oxidative stress and neuronal resilience: implications for the pathophysiology of bipolar disorders Gabriela Delevati Colpo, Gabriel Rodrigo Fries, Laura Stertz and Flávio Kapczinski
7. Post-mortem studies in bipolar disorder Francine M. Benes and Sivan Subburaju
8. The neuroendocrinology of stress in the pathophysiology of bipolar disorders Allan Young and Alessandro Colasanti
9. Brain imaging abnormalities in bipolar disorder Marsal Sanches and Jair C. Soares
10. Sleep and circadian rhythms in bipolar disorders Sara Dallaspezia and Francesco Benedetti
11. Infectious agents: role in causation of bipolar disorders? Olaoluwa O. Okusaga
12. EEGs and ERPs in bipolar disorders R. Hamish McAllister-Williams
13. Genetic factors in the etiology of bipolar disorder Consuelo Walss-Bass
14. Neurocognitive findings in bipolar disorder David C. Glahn, Carrie E. Bearden and Sophia Frangou
15. Psychotherapeutic interventions in bipolar disorder Thomas Daniel Meyer
16. The kindling/sensitization model and the pathophysiology of bipolar disorder Robert M. Post
17. Biological factors in bipolar disorder in childhood and adolescence Melissa A. Brotman, Banafsheh Sharif-Askary, Daniel P. Dickstein and Ellen Leibenluft
18. Biological factors in bipolar disorder in late life Brent Forester, Ariel G. Gildengers and Robert C. Young
19. Perspectives for new pharmacological interventions Charles L. Bowden
20. Physical health and metabolic dysfunction in bipolar disorder Joshua D. Rosenblat, Danielle S. Cha, Rodrigo B. Mansur and Roger S. McIntyre
21. Immune dysregulation in bipolar disorder Antonio Lucio Teixeira, Izabela Guimarães Barbosa and Moisés Evandro Bauer
Index

Jair C. Soares, University of Texas Health Science Center, Houston
Jair C. Soares is Professor and Chairman of the Department of Psychiatry and Behavioral Sciences at the University of Texas Health Science Center in Houston. He is also Director of the UT Center of Excellence on Mood Disorders. Between 1998 and 2002, he co-edited the journal Bipolar Disorders: An International Journal of Psychiatry and Neurosciences and he is currently the joint Editor-in-Chief of the Journal of Affective Disorders. He has published more than 200 peer-reviewed manuscripts, and has also edited three textbooks: Brain Imaging Investigations on Affective Disorders, Bipolar Disorders: Basic Mechanisms and Therapeutic Implications, and Handbook of Medical Psychiatry.

Allan Young, King's College London
Allan Young holds the Chair of Mood Disorders at King's College London where he is also Director of the Centre for Affective Disorders within the Department of Psychological Medicine in the Institute of Psychiatry. He has published over 300 peer-reviewed publications and a number of books about psychopharmacology and affective disorders, including Bipolar Disorders: Basic Mechanisms and Therapeutic Implications and Practical Management of Bipolar Disorder. He is currently President of the International Society for Affective Disorders and Chair of the Psychopharmacology Special Committee of the Royal College of Psychiatrists.
Contributors

Michael J. Ostacher, Mark A. Frye, Trisha Suppes, Trevor R. Norman, Alexander W. Charney, Sehrish Sayed, Dennis S. Charney, Martin J. Lan, J. John Mann, Paul Stokes, James Stone, Gabriela Delevati Colpo, Gabriel Rodrigo Fries, Laura Stertz, Flávio Kapczinski, Francine M. Benes, Sivan Subburaju, Allan Young, Alessandro Colasanti, Marsal Sanches, Jair C. Soares, Sara Dallaspezia, Francesco Benedetti, Olaoluwa O. Okusaga, R. Hamish McAllister-Williams, Consuelo Walss-Bass, David C. Glahn, Carrie E. Bearden, Sophia Frangou, Thomas Daniel Meyer, Robert M. Post, Melissa A. Brotman, Banafsheh Sharif-Askary, Daniel P. Dickstein, Ellen Leibenluft, Brent Forester, Ariel G. Gildengers, Robert C. Young, Charles L. Bowden, Joshua D. Rosenblat, Danielle S. Cha, Rodrigo B. Mansur, Roger S. McIntyre, Antonio Lucio Teixeira, Izabela Guimarães Barbosa, Moisés Evandro Bauer