Primary Carcinomas of the Liver

Primary carcinomas of the liver are increasing in incidence in the developed world, probably due to dietary and environmental factors as well as the known role of infective agents such as Hepatitis C. They are usually diagnosed in the advanced stages and carry high morbidity and mortality. This volume summarises the latest developments in imaging of primary hepatic carcinomas, emphasising the multidisciplinary approach to the care of patients. In addition to extensive chapters on the radiological issues surrounding diagnosis and staging of the malignancies, individual chapters on epidemiology, pathology, and surgical and non-surgical treatment options are included. All treatment options are considered for both HCC and cholangiocarcinoma, including newer techniques such as TACE. Only by a well orchestrated multidisciplinary team approach including epidemiologists, diagnostic radiologists, hepatologists, oncologic surgeons, radiation oncologists, and pathologists can these complex malignancies be managed successfully. - Reviews the key imaging findings for both common and uncommon liver neoplasms - Concise, practical discussion of the use of imaging by an international team of experts from all members of the multidisciplinary cancer care team - Evaluates each imaging modality used in the diagnosis and staging of primary liver carcinomas, advising on the most appropriate imaging test - Both surgical and non-surgical treatment options reviewed Contents Series foreword; Preface to Primary Carcinomas of the Liver; 1. Epidemiology hepatocellular carcinoma (HCC) and cholangiocarcinoma Jorge A. Marrero; 2. Surveillance/screening for hepatocellular carcinoma Jorge A. Marrero and Hero K. Hussain; 3. Pathology of hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma Barbara McKenna and Sharon Bihlmeyer; 4. Radiological diagnosis of HCC Jonathon M. Willatt, Hero K. Hussain and Isaac R. Francis; 5. Staging of hepatocellular carcinoma Jorge A. Marerro and Hero K. Hussain; 6. Surgical treatment of HCC: resection and transplantation Sean Kumer and Shawn J. Pelletier; 7. Non-surgical treatment of HCC: 7.1 Regional therapies for treatment of intermediate stage HCC: a. Trans-arterial chemoembolization (TACE) Venkat N. Krishnamurthy; b. Ablation of hepatocellular carcinoma Elaine M. Caoili; 7.2 Systemic therapies for advanced HCC: a. Review of current status of radiotherapy for the treatment of hepatocellular carcinoma Orit Gutfeld and Charlie Pan; b. Review of current status of chemotherapy for the treatment of hepatocellular carcinoma Edward Kim and Mark Zalupski; 8. Radiological identification of recurrent or residual hepatocellular carcinoma Peter S. Liu, Ajaykumar C. Morani and Hero K. Hussain; 9. Radiological diagnosis of cholangiocarcinoma Hero K. Hussain and Isaac R. Francis; 10. Staging of cholangiocarcinoma Hero K. Hussain and James A. Knol; 11. Non-surgical treatment of cholangiocarcinoma: a. Radiotherapy Orit Gutfeld and Charlie Pan; b. Systemic therapy of cholangiocarcinoma Gazala N. Khan and Mark M. Zalupski; 12. Uncommon hepatic tumors Peter S. Liu and Hero K. Hussain; Index. Contributors Jorge A. Marrero, Hero K. Hussain, Barbara McKenna, Sharon Bihlmeyer, Jonathon M. Willatt, Isaac R. Francis, Sean Kumer, Shawn J. Pelletier, Venkat N. Krishnamurthy, Elaine M. Caoili, Orit Gutfeld, Charlie Pan, Edward Kim, Mark Zalupski, Peter S. Liu, Ajaykumar C. Morani, James A. Knol, Gazala N. Khan, Mark M. Zalupski