Transfusion Microbiology

Extensive measures are taken to ensure that blood transfusion poses a minimal microbiological hazard to recipients. Transfusion Microbiology is the definitive text on all aspects of transfusion transmitted infections. This comprehensive text covers all medical, scientific, technical and developmental aspects of this critically important sector of transfusion medicine. A detailed discussion of all infective agents, donor issues, testing and pathogen inactivation is provided. Agents causing major concern recently, such as vCJD, are considered in the context of historical experience with agents such as HIV. All aspects of risk assessment, regulation, cost benefit analysis and quality management are reviewed. Relevant to blood transfusion centres, hospital transfusion laboratories, haematologists and microbiologists, medical, scientific and technical staff, universities and general training programmes worldwide, Transfusion Microbiology provides an up-to-date resource for all practitioners and researchers involved in transfusion medicine. - All infective agents discussed in detail, written and edited by the leading authorities worldwide - Key issues in donor assessment, blood testing for pathogens and pathogen inactivation reviewed - Risk analysis, regulatory issues and cost benefit analysis also discussed CONTENTS Foreword Roger Y. Dodd; Preface; Acknowledgements; Glossary; Introduction John A. Barbara, Roger Eglin; Part I. Agents: 1. Hepatitis viruses Denis M. Dwyre and Paul V. Holland; 2. Anti-HBc Joan O'Riordan; 3. Herpes viruses Eleftherios C. Vamvaka and Gary E. Tegtmeier; 4. Retroviruses Brian C. Dow, E. W. Fiebig and Michael P. Busch; 5. Parvovirus B19 (human erythroviruses) Kevin E. Brown; 6. Emerging viruses in transfusion Jean-Pierre Allain; 7. Bacterial contamination in blood and blood components Carl P. McDonald and M. A. Blajchman; Annexe, Syphilis Brian C. Dow; 8. The protozoan parasites David A. Leiby and Silvano Wendel; 9. Prion diseases Marc L. Turner, Patricia E. Hewitt, Moira Bruce and James W. Ironside; Annexe, Testing for prions David Anstee and Gary Mallinson; Part II. Selection and Testing: 10. Blood donor selection and qualification Virge James; 11. Current serological methods of testing and automation Peter D. Rogan; 12. Confirmatory testing and donor readmission Alan D. Kitchen and Brian C. Dow; 13. The strategy for applications of nucleic acid testing Paul R. Grant and Richard S. Tedder; 14. Nucleic acid testing, general view W. Kurt Roth; 15. Nucleic acid testing, the US approach Susan L. Stramer; 16. Nucleic acid testing, the English approach Roger Eglin; 17. Quality in the screening of donations for transfusion transmissible infections Alan D. Kitchen and John A. Barbara; 18. Microbiological blood testing and new technologies Juraj Petrik; 19. Processing and components, Leucodepletion and pathogen reduction Rebecca Cardigan, Chris Prowse and Lorna M. Williamson; 20. Fractionated products Peter R. Foster and Carol Bienek; Part III. Surveillance, Risk and Regulation: 21. Serious hazards of transfusion (SHOT), Haemovigilance Elizabeth M. Love; 22. Investigation of post transfusion infection Patricia E. Hewitt and Chris Moore; 23. Notification of donors with significant microbiological test results Patricia E. Hewitt and Chris Moore; 24. Researching the natural history of transfusion transmitted infections, the UK hepatitis C national register Helen Harris; 25. How to assess risk, prospective studies and calculations Kate Soldan and Katy Davison; 26. Risk management Arturo Pereira; 27. The regulatory environment in Europe Virge James; 28. Blood safety in developing countries Jean-Pierre Allain, Elizabeth Vinelli and Yasmin Ayob; Index