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Cancer imposes daunting effects on the nervous system. Brain cancer is one of the most devastating diagnoses a physician can deliver. Cancer of the nervous system can take many different forms. Treatment is specific to the type of malignancy, its location in the nervous system and, increasingly, its molecular characteristics. The challenges manifest further when management choices need to be made, and multidisciplinary approaches are required. Additional complexities arise in children, where the developing neurological system requires more sensitive treatment. Neuro–oncology unmasks the complexities to provide a straightforward guide to cancers of the nervous system. Following a general approach to diagnosis and treatment, the clinical aspects of specific cancer types in adults and children are explained in practical terms. A final section considers the effect of system cancer on the nervous system and the side effects of treatment. Clinical in approach, practical in execution, Neuro–oncology will help you diagnose and manage your patients more effectively. About the Authors Roger J. Packer, MD, Center for Neuroscience and Behavioral Medicine, Brain Tumor Institute, Gilbert Family Neurofibramatosis Institute, Children′s National, Washington, DC, USA David Schiff, MD, Departments of Neurology, Neurological Surgery, and Medicine, University of Virginia Health Science Center, Charlottesville, VA, USA Contents List of Contributors, xxx Foreword Preface Acknowledgements Section I: Overview and General Aspects of Theory 1 Diagnosis of Brain Tumors: Clinical and Radiographic Isabel Arrillaga–Romany, Eudocia Quant Lee and Patrick Y. Wen 2 Epidemiology and Etiology Melissa L. Bondy, Yanhong Liu and Michael Scheurer 3 General Aspects of Surgery Brian Williams, Robert Louis and Mark Shaffrey 4 General Approach to Radiation Oncology Jennifer S. Yu and Daphne Haas–Kogan 5 General Aspects of Chemotherapy including "Biologic Agents" Jethro Hu and Santosh Kesari Section II: Adult Nervous System Tumors 6 Malignant Gliomas in Adulthood Michael Ivan, Matthew Tate, and Jennifer Clarke 7 LGG and Oligodendrogliomas in Adulthood Derek R Johnson and Kurt A. Jaeckle 8 Ependymomas Kanwal P.S. Raghav and Mark Gilbert 9 Germ Cell Tumors and Other Pineal Region Tumors Geneviève Legault and Jeffrey C. Allen 10 Sellar Tumors: Pituitary Adenomas and Craniopharyngiomas Robert G. Louis and Robert Dallapiazza and John Jane Jr. 11 Meningiomas Wendy Sherman and Jeffrey Raizer 12 Intradural Spinal Cord Tumors Ben Shofty, Akiva Korn, Zvi Lidar and Shlomi Constantini Section III: Pediatric Brain Tumors 13 Gliomas in Childhood Bruce H. Cohen 14 Embryonal Tumors Roger J. Packer 15 Infantile Brain Tumors Alyssa Reddy Section IV: Systemic Concerns to the CNS and Treatment Sequelea 16 Primary Central Nervous System Lymphomas Jerome Graber and Antonio M.P. Omuro 17 Intracranial Metastases Mary Welch and Thomas J. Kaley 18 Spinal Cord Compression Melike Mut 19 Leptomeningeal Metastases Sean Grimm and Marc Chamberlain 20 Immune Mediated Paraneoplastic Neurologic Disorders: An Overview Myrna R. Rosenfeld and Josep Dalmau 21 Neurotoxicity of Radiation Therapy and Chemotherapy Eudocia C. Quant Lee Neurology in Practice Series : Robert A Gross , MD, PhD, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA Jonathan W Mink, MD, PhD, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA The Neurology in Practice series provides clinical ′in the office′ or ′at the bedside′ guides to effective patient care for neurologists. The tone is practical, not academic, with authors offering guidance on what might be done and what should be avoided. The books are informed by evidence–based practice and feature: * Algorithms and guidelines where they are appropriate * ′Tips and Tricks′ boxes – hints on improving outcomes * ′Caution′ warning boxes – hints on avoiding complications * ′Science Revisited′ – quick reminder of the basic science principles * Summaries of key evidence and suggestions for further reading