Sarcoidosis

Sarcoidosis represents a major challenge for physicians - not just in respiratory medicine, but across a range of specialties. This book, with a multi-disciplinary authorship of the highest standard, presents the most up to date thinking on all aspects of the condition, from epidemiology to clinical manifestations and treatment options. Full coverage is given to both respiratory and non-respiratory aspects; the basic science that underlies the disease and its progression is evaluated in detail, and placed into its correct clinical context. Possible future advances are covered in a concluding section. The editors - all leading figures in the field with international reputations - have compiled the definitive work on the subject in a single volume. The book is fully comprehensive and evidence-based and will be an essential addition to the bookshelves of all whose practice involves the care and treatment of patients with sarcoidosis. * The definitive work on the subject: evidence-based and comprehensive * Edited by leading figures from the UK and US, with an international chapter authorship * Considers all aspects of the condition - from epidemiology through diagnosis to treatment options and possible future advances * Generously illustrated throughout Table of Contents: Section 1 Historical Survey, definition, epidemiology Historical survey Definition Epidemiology [including prevalence, incidence and modes of presentation] Section 2 Aetiology, Pathology, Immunology and Genetics Aetiology Pathology [including ultrastructure and lavage] Immunology Genetics Section 3 Investigations The radiology of the lungs and the pleura Intervention and radiological procedures [including PET and ultrasound] Lung function [including fitness to fly, blood gases) Endoscopy Lavage DEXA scanning [including untreated inactive, active and resurgant sarcoidosis] Nuclear medicine imaging ECG; Holter monitoring; exercise tests Tuberculin skin tests and ELISPOT The Kveim reaction – in vivo and in vitro Serology; serum ACE, proteins, liver function tests, serum calcium and 24 hour urinary calcium excretion, etc Sleep studies Section 4 The heart Upper respiratory tract Asthma/irritable airways Pulmonary fibrosis The heart, pericardium, large and small vessels Pulmonary hypertension Echo MRI Thallium/gallium studies The upper respiratory tract Asthma/irritable airways Pulmonary fibrosis Section 5 Liver and GI tract Spleen, blood and bone marrow The nervous system Renal and calcium metabolism Psychiatric aspects The liver and gastrointestinal tract The spleen, blood and bone marrow The nervous system CSF MRI The kidneys and calcium metabolism [including renal transplantation and gastrourinary tract] Psychiatric aspects Section 6 The skin Ocular changes Bones joints and skeletal muscles Superficial lymphadenopathy The endocrine glands Sarcoidosis of the skin Ocular changes Neuro-ophthalmology Bones, joints and skeletal muscles [including radiology] Peripheral muscles Superficial lymphadenopathy The endocrine glands Section 7 Beryllium disease Sarcoidosis/HIV and AIDS Sarcoid; relationships to neoplasm Chapter 29 Sarcoid/HIV and AIDS Sarcoid/relationship to neoplasm/chemotherapy [including isolated breast lesions] Sarcoid/antibody deficiency syndromes Concomitant or associated disorders Infections with agents causing granulomatous inflammation – mycobacteria, aspergillosis, nocardiasis, toxoplasma, herpes simplex, etc. Miscellaneous associated disorders including Sjogren’s syndrome, gamma globulin deficiency, SLE, polyarteritis nodosa, amyloidosis, bronchiectasis, Crohn’s, UC, etc. Section 8 Childhood sarcoid Pulmonary and extrapulmonary involvement by sarcoidosis in childhood Section 9 Diagnosis and treatment of sarcoidosis Diagnosis of sarcoidosis: history, physical examination, presumptive diagnosis without biopsy, sources of biopsy material, utilisation of investigations and imaging Treatment of sarcoidosis: Philosophical considerations Surveillance aspects Treatment; first and second line drugs Recently introduced modes of suppressive therapy Section 10 Surgical investigations and management Pulmonary/cardiac transplantation Physiotherapy Rehabilitation Immunisation/vaccination and advice Surgical investigation and management Pulmonary/cardiac transplantation Physiotherapy in sarcoidosis Rehabilitation [including fatigue, pain, exercise intolerance, diaphragmatic function, granulomatous infiltration] Quality of life and long-term oxygen therapy Immunisation/vaccination [including BCG, multiviral protection, flu vaccine, etc] Section 11 Future considerations Future progress in investigations and management About the Author(s): Donald N Mitchell MD FRCP Hon Consultant Physician Royal Brompton and University College Hospitals London, UK David R Moller MD Professor of Medicine and Director Sarcoidosis Clinic and Research Program Department of Medicine The Johns Hopkins University School of Medicine Baltimore, Maryland, USA Stephen G Spiro BSc MD FRCP Professor of Respiratory Medicine and Honorary Consultant Physician University College London and The Royal Brompton Hospital London, UK Athol Wells MBChB MD FRACP FRCP FRCR Professor of Respiratory Medicine and Head of Interstitial Lung Disease Unit The Royal Brompton Hospital London, UK