Pancreas, Islet and Stem Cell Transplantation for Diabetes

Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreas transplantation however must be balanced against the risk of the operative procedure and the innovative long-term immunosuppressive therapy. The indications for this procedure and the selection of the patients are critical to ensure low mortality and any improvements in quality of life. This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantation and islet and pancreatic stem cell transplantation. Fully updated since the previous edition to cover new developments in the field Written by an international and expert team of contributors Focuses on pancreas transplantation as the treatment of choice for diabetic patients New to this edition Reflects the growing interest in stem cell research applicable to this condition Expanded sections on islets and pancreas transplantation Nadey S. Hakim , Consultant in General Surgery, Hammersmith Hospital, London, UK, Robert J. Stratta , Professor of Surgery, Director of Transplantation, Wake Forest University School of Medicine, USA, Derek Gray , Professor of Experimental Surgery, Nuffield Department of Surgery, University of Oxford, UK, Peter Friend , Consultant in General Surgery, Nuffield Department of Surgery, University of Oxford, UK, and Alan Colman , Executive Director, Singapore Stem Cell Consortium, Institute of Medical Biology, Singapore CONTENTS 1: The history of pancreas transplantation 2: The nature of the problem: why do we need pancreatic transplantation? 3: Experimental models in whole organ pancreatic transplantation 4: Indications, patient evaluation and selection 5: Donor management and selection in pancreas transplantation 6: Procurement and benchwork preparation of the pancreatic graft 7: Pancreas preservation 8: Surgical techniques of pancreas transplantation 9: Immunosuppression for pancreas transplantation 10: Pancreatic rejection: histology, diagnosis and treatment 11: Surgical complications of pancreas transplantation 12: Medical and urological complications of pancreas and kidney/ pancreas transplantation 13: Post-transplant glucose intolerance 14: Long term metabolic and other consequences of pancreas and islet transplantation 15: Quality issues in pancreas transplantation 16: Pancreas transplantation using living donors 17: Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) 18: Insulin Gene Therapy 19: A historical view for the development of cellular and islet transplantation 20: Fetal and neonatal pancreatic tissue transplantation 21: Experimental approaches to the prevention of islet rejection 22: Suitable donor selection, techniques of islet isolation and purification for human islet allograft transplantation 23: Outcomes and clinical effectiveness of islet transplantation 24: Islet auto-transplantation 25: Approaches to immunological tolerance and potential application in pancreatic islet transplantation 26: History of pancreatic stem cell transplantation and alternative islet sources 27: Stem cell therapy for the treatment of diabetes 28: Future challenges in Beta cell replacement therapies 29: Beta cell regenearation in the post-natal pancreas 30: Gene and stem cell therapy for diabetes