50 Studies Every Pediatrician Should Know

50 Studies Every Pediatrician Should Know presents key studies that have shaped the current clinical practice of pediatrics. Selected using a rigorous methodology, the studies cover topics including: allergy immunology, behavioral, cardiology, dermatology, endocrinology, ENT, general pediatrics, hematology, infectious disease, neonatology, nephrology, neurology, oncology, ophthalmology, orthopedics, and pulmonary. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This is one of the only books of its kind to present a collection of the most influential clinical trials in pediatrics that are detailed enough to be used on rounds, but still easily digestible.

CONTENTS

Section I: Allergy Immunology
1. Efficacy of Immunoglobulin Plus Prednisolone in Prevention of Coronary Artery Abnormalities in Kawasaki Disease
Section II: Behavioral
2. Measles, Mumps, and Rubella Vaccination and Autism
3. Treatment for adolescents with depression study (TADS)
4. The Multimodal Treatment Study of Children with Attention Deficit/Hyperactivity Disorder (MTA)
Section III: Cardiology
5. Pharmacologic Closure of a Patent Ductus Arteriosus in Premature Infants
6. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa heart study
Section IV: Dermatology
7. Propranolol vs. Prednisolone for Symptomatic Proliferating Infantile Hemangiomas: A Randomized Clinical Trial
Section V: Endocrinology
8. Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis
Section VI: ENT
9. A Trial of Early Ear Tube Placement in Children with Persistent Otitis Media
Section VII: General Pediatrics
10. Maintenance IV Fluid Requirements
11. Predischarge Serum Bilirubin to Predict Significant Hyperbilirubinemia in Newborns
12. Sudden Infant Death Syndrome Risk Factors: The Chicago Infant Mortality Study
13. Treatment of Acute Otitis Media in Children
14. The Human Papillomavirus Vaccine
15. Evidence of Decrease in Vaccine-Type Human Papillomavirus (HPV) and Herd Protection in Adolescents and Young Women
16. Effects of Lead Exposure in Childhood
Section VIII: Hematology
17. Iron Supplementation for Breastfed Infants
18. Transfusion Strategies for Patients in Pediatric Intensive Care Units
19. Prophylactic Penicillin in Sickle Cell Anemia
Section IX: Infectious Disease
20. Empiric Antimicrobial Therapy for Skin and Soft-Tissue Infections
21. Infants at Low Risk for Serious Bacterial Infection
22. Outpatient Treatment of Febrile Infants at Low Risk for Serious Bacterial Infection
23. Outpatient Treatment of Selected Febrile Infants Without Antibiotics
24. Neonatal Fever Without a Source
25. Serious Bacterial Infections and Viral Infections in Febrile Infants
26. Chest Radiograph and Lower Respiratory Tract Infection
27. Vidarabine Therapy of Neonatal Herpes Simplex Virus Infection
28. Early Reversal of Pediatric and Neonatal Septic Shock
29. Reduction of vertical transmission of human immunodeficiency virus (HIV)
30. Palivizumab prophylaxis against Respiratory Syncytial Virus (RSV) in high risk infants
31. The Spectrum of Bronchiolitis
32. Preventing Early-Onset Neonatal Group B Streptococcal Disease
Section X: Neonatology
33. Apgar Scoring of Infants at Delivery
34. Prophylactic Treatment with Human Surfactant in Extremely Preterm Infants
Section XI: Nephrology
35. Oral versus Initial Intravenous Antibiotics for Urinary Tract Infection in Young Febrile Children
36. Identifying children with minimal change disease (MCD)
37. Chronic renal disease following poststreptococcal glomerulonephritis
Section XII: Neurology
38. Antipyretic Agents for Preventing Febrile Seizure Recurrence
39. Febrile Seizures and Risk for Epilepsy
40. Seizure Recurrence After First Unprovoked Afebrile Seizure
41. Mortality and Childhood-Onset Epilepsy
42. Identifying Children with Low-Risk Head Injuries Who Do Not Require Computed Tomography
Section XIII: Oncology
43. Health-Related Quality of Life Among Children with Acute Lymphoblastic Leukemia
Section XIV: Ophthalmology
44. Treatment of Acute Conjunctivitis in Children
45. Screening for Amblyopia
Section XV: Orthopedics
46. Differentiation Between Septic Arthritis and Transient Synovitis of the Hip in Children
Section XVI: Pulmonary
47. Steroids for the Treatment of Croup
48. Inhaled Corticosteroids for Mild Persistent Asthma
49. Inhaled Salbutamol (Albuterol) vs. Injected Epinephrine in Acute Asthma
50. Long-term Inhaled Hypertonic Saline for Cystic Fibrosis

Ashaunta T. Anderson, Robert Wood Johnson Clinical Scholar, University of California, Los Angeles, Nina L. Shapiro, Director of Pediatric Otolaryngology; Associate Professor of Head and Neck Surgery, University of California Los Angeles, Stephen C. Aronoff, Waldo E. Nelson Professor and Chair, Department of Pediatrics, Temple University, Jeremiah Davis, Pediatric Resident, Seattle Children's Hospital and University of Washington, Michael Levy, Clinical lecturer, Department of Pediatrics and communicable diseases, hospitalist division, University of Michigan, and Series edited by Michael E. Hochman, Medical Director for Innovation; Robert Wood Johnson Foundation Clinical Scholar, AltaMed Health Services; , Department of Internal Medicine, University of California, Los Angeles

Ashaunta T. Anderson is a Robert Wood Johnson Clinical Scholar at the University of California in Los Angeles, California. Nina L. Shapiro is the Director of Pediatric Otolaryngology and an Associate Professor of Head and Neck Surgery at the UCLA David Geffen School of Medicine in Los Angeles, California. Stephen C. Aronoff is the Waldo E. Nelson Professor and Chairman of Pediatrics at Temple University in Philadelphia, Pennsylvania. Jeremiah Davis is a Pediatric Resident at Seattle Children's Hospital and the University of Washington in Seattle, Washington. Michael Levy is a Pediatric Clinical Lecturer at the University of Michigan and C.S. Mott Children's Hospital which in Ann Arbor, Michigan.