Genomic and Precision Medicine: Inflammatory and Metabolic Disease

Genomic and Precision Medicine: Inflammation and Metabolic Disorders. Third Edition provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.

Key Features

    Offers comprehensive coverage of inflammation and metabolic disease genomics
    Provides succinct commentary and key learning points to assist providers with the implementation of genomic and personalized medicine
    Presents an up-to-date overview on major opportunities for genomic and personalized medicine
    Includes case studies that highlight the practical use of genomics in the management of patients

Table of Contents

    Overview:  Genome wide approaches to Inflammatory and Metabolic disease
    2. Application of Human Genome Information to Clinical Practice
    • Genome sequencing: new technologies, approaches, applications
    • Clinical applications of whole-genome chromosomal microarray analysis
    • Transcriptomics in the age of ultra high-throughput sequencing
    • Quantitative Proteomics in Genomic Medicine
    3. Translating genome information into clinical practice and human health
    4. Big Data and Translational Bioinformatics Genomic and Personalized Medicine
    • Biospecimen Banking linked to phenotype data
    • Electronic Health Records
    • Data Sharing and Privacy
    5. Health Risk Assessment and Family History
    6. Clinical Decision Support
    7. Overview of Policy, Ethical and Social Considerations
    8. Autoimmune Disorders
    9. Rheumatoid Arthritis
    10. Multiple Sclerosis
    11. Inflammatory Bowel Disease
    12. Asthma
    13. Chronic Obstructive Pulmonary Disease
    14. Interstitial Lung Disease
    15. Peptic Ulcer Disease
    16. Cirrhosis
    17. Systemic Sclerosis
    18. Lupus
    19. Osteoarthritis
    20. Diabetes Genomics
    21. The Metabolic Syndrome
    22. Approaching Obesity
    • The Microbiome and obesity
    23. Case Studies

Dr. Ginsburg is the founding Director of the Center for Applied Genomics & Precision Medicine in the Duke Institute for Genome Sciences & Policy. He is also Professor of Medicine and of Pathology at Duke University Medical Center, Professor of Biomedical Engineering at Duke Pratt School of Engineering, and Co-Director of the Duke Translational Medicine Institute.

Huntington Willard is on the faculty of the Department of Human Genetics at the University of Chicago. Prior to this appointment, Willard was the President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. He was previously on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to 2014, the Nanaline H. Duke Professor of Genome Sciences, and the Arts & Sciences Professor of Biology & Genome Sciences.
Affiliations and Expertise

Chris Woods, Professor, Medicine and Global Health, Chief, Infectious Disease Division, Durham VA Medical Center, Duke University School of Medicine, USA

Dr. Tsalik obtained his MD and PhD at Columbia University before coming to Duke for his clinical training in Internal Medicine followed by fellowship in Infectious Diseases. He is currently an Associate Professor of Medicine, Associate Professor of Molecular Genetics and Microbiology, and is a Physician in the Emergency Department at the Durham VA Health Care System. He is also Associate Director of Diagnostics for the Antibacterial Resistance Leadership Group. His research focuses on the host response to infection with a particular emphasis on translation to diagnostic tests.