Principles of Tissue Engineering

First published in 1997, this new edition of Principles of Tissue Engineering is the widely recognized definitive resource in the field. It provides the most complete summary of basic concepts and applications in the biology and design of tissues and organs, emphasizing state-of-the-art approaches to the treatment of human disease. The expert authors reflect the multi-disciplinary nature of the field, which draws upon biology, chemistry, materials science, and engineering principles, and emphasize topics based on their likely clinical impact. Edited by Robert Lanza, Advanced Cell Technology, MA, USA ; Robert Langer, Massachusetts Institute of Technology, Cambridge, U.S.A. and Joseph P. Vacanti, Harvard Medical School and the Massachusetts General Hospital, Boston, U.S.A. Table of Contents: INTRODUCTION TO TISSUE ENGINEERING 1. The History and Scope of Tissue Engineering Joseph P. Vacanti and Charles A. Vacanti 2. The Challenge of Imitating Nature Robert M. Nerem 3. Moving into the Clinic Alan J. Russell and Timothy Bertram 4. Future Perspectives Mark E. Furth and Anthony Atala PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION 5. Molecular Biology of the Cell Jonathan Slack 6. Organization of Cells into Higher-Ordered Structures Jon D. Ahlstrom and Carol A. Erickson 7. Dynamics of Cell-ECM Interactions M. Petreaca and Manuela Martins-Green 8. Matrix Molecules and Their Ligands Bjorn Reino Olsen 9. Morphogenesis and Tissue Engineering A.H. Reddi 10. Gene Expression, Cell Determination and Differentiation William Nikovits, Jr. and Frank E. Stockdale PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT 11. Engineering Functional Tissues Lisa E. Freed and Farshid Guilak 12. Principles of Tissue Culture and Bioreactor Design R.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic 13. Regulation of Cell Behavior by Extracellular Proteins Amy Bradshaw and E. Helene Sage 14. Growth Factors Thomas F. Deuel and Yunchao Chang 15. Mechanochemical Control of Cell Fate Switching Donald E. Ingber PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS 16. In Vivo Synthesis of Tissues and Organs Brendan A. Harley and Ioannis V. Yannas PART FOUR: MODELS FOR TISSUE ENGINEERING 17. Models as Precursors for Prosthetic Devices Eugene Bell 18. Quantitative Aspects Alan J. Grodzinsky, Roger D. Kamm, and Douglas A. Lauffenburger PART FIVE: BIOMATERIALS IN TISSUE ENGINEERING 19. Micro-Scale Patterning of Cells and Their Environment Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides 20. Cell Interactions with Polymers W. Mark Saltzman and Themis R. Kyriakides 21. Matrix Effects Jeffrey A. Hubbell 22. Polymer Scaffold Fabrication Matthew B. Murphy and Antonios G. Mikos 23. Biodegradable Polymers James M. Pachence, Michael P. Bohrer and Joachim Kohn 24. Micro- and Nanofabricated Scaffolds Christopher J. Bettinger, Jeffrey T. Borenstein and Robert Langer 25. Three-Dimensional Scaffolds Ying Luo, George Engelmayr, Debra T. Auguste, Lino da Silva Ferreira, Jeffrey M. Karp, Rajiv Saigal and Robert Langer PART SIX: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES 26. Tissue Engineering and Transplantation in the Fetus Dario O. Fauza 27. Immunomodulation Denise L. Faustman 28. Immunoisolation Beth A. Zielinski and Michael J. Lysaght 29. Engineering Challenges in Immunobarrier Device Development Amy S. Lewis and Clark K. Colton PART SEVEN: STEM CELLS 30. Embryonic Stem Cells Alan Trounson 31. Adult Epithelial Tissue Stem Cells Christopher S. Potten and James W. Wilson 32. Embryonic Stem Cells as a Cell Source for Tissue Engineering Ali Khademhosseini, Jeffrey M. Karp, Sharon Gerecht, Lino Ferreira, Gordana Vunjak-Novakovic and Robert Langer 33. Postnatal Stem Cells Pamela Gehron Robey and Paulo Bianco PART EIGHT: GENE THERAPY 34. Gene Therapy Ronald G. Crystal and Stefan Worgall 35. Gene Delivery into Cells and Tissues Ales Prokop and Jeffrey M. Davidson PART NINE: BREAST 36. Breast Reconstruction Lamont Cathey, Kuen Yong Lee, Walter D. Holder, David J. Mooney and Craig R. Halberstadt PART TEN: CARDIOVASCULAR SYSTEM 37. Progenitor Cells and Cardiac Homeostasis Annarosa Leri, Toru Hosoda, Marcello Rota, Claudia Bearzi, Konrad Urbanek, Roberto Bolli, Jan Kejstura and Piero Anversa 38. Cardiac-Tissue Engineering M. Radisic, H. Park and G. Vunjak-Novakovic 39. Blood Vessels Luke Brewster, Eric M. Brey and Howard P. Greisler 40. Heart Valves Peter Marc Fong, Jason Park and Christopher Kane Breuer PART ELEVEN: ENDOCRINOLOGY AND METABOLISM 41. Generation of Islets from Stem Cells Bernat Soria, Abdelkrim Hmadcha, Francisco J. Bedoya and Juan R. Tejedo 42. Bioartificial Pancreas Athanassios Sambanis 43. Engineering Pancreatic Beta-Cells Hee-Sook Jun and Ji-Won Yoon 44. Thymus and Parathyroid Organogenesis Craig Scott Nowell, Ellen Richie, Nancy Ruth Manley and Catherine Clare Blackburn PART TWELVE: GASTROINTESTINAL SYSTEM 45. Adult Stem Cells in Normal Gastrointestinal Function and Inflammatory Disease Mairi Brittan and Nicholas A. Wright 46. Alimentary Tract Shaun M. Kunisaki and Joseph Vacanti 47. Liver Stem Cells Eric Lagasse 48. Liver Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia PART THIRTEEN: HEMATOPOIETIC SYSTEM 49. Hematopoietic Stem Cells Malcolm A.S. Moore 50. Red Blood Cell Substitutes Thomas M. S. Chang 51. Lymphoid Cells Una Chen PART FOURTEEN: KIDNEY AND GENITOURINARY SYSTEM 52. Stem Cells in Kidney Development and Regeneration Gregory R. Dressler 53. Renal Replacement Devices H. David Humes 54. Genitourinary System Anthony Atala PART FIFTEEN: MUSCULOSKELETAL SYSTEM 55. Mesenchymal Stem Cells Faye H. Chen, Lin Song, Robert L. Mauck, Wan-Ju Li and Rocky S. Tuan 56. Bone Regeneration Chantal E. Holy, F. Jerry Volenec, Jeffrey Geesin and Scott P. Bruder 57. Bone and Cartilage Reconstruction Wei Liu, Wenjie Zhang and Yilin Cao 58. Regeneration and Replacement of the Intervertebral Disc Lori A. Setton, Lawrence J. Bonassar and Koichi Masuda 59. Articular Cartilage Injury Joseph A. Buckwalter, J.L. Marsh, T. Brown, A. Amendola and J.A. Martin 60. Tendons and Ligaments Francine Goulet, Lucie Germain, A. Robin Poole and Francois A. Auger 61. Mechanosensory Mechanisms in Bone Upma Sharma, Antonios G. Mikos and Stephen C. Cowin 62. Skeletal-Tissue Engineering Matthew D. Kwan, Derrick C. Wan and Michael T. Longaker PART SIXTEEN: NERVOUS SYSTEM 63. Neural Stem Cells Lorenz Studer 64. Brain Implants Lars U. Wahlberg 65. Spinal Cord Injury John W. McDonald and Daniel Becker 66. Protection and Repair of Audition Richard Altschuler, Yehoash Raphael, David C. Martin, Jochen Schacht, David J. Anderson and Josef M. Miller PART SEVENTEEN: OPHTHALMIC APPLICATIONS 67. Stem Cells in the Eye Michael E. Boulton, Julie Albon and Maria B. Grant 68. Corneal-Tissue Replacement Jeffrey W. Ruberti, James D. Zieske and Vickery Trinkaus-Randall 69. Vision Enhancement Systems Gislin Dagnelie PART EIGHTEEN: ORAL/DENTAL APPLICATIONS 70. Biological Tooth Replacement and Repair Anthony J. (Tony) Smith and Paul T. Sharpe 71. Oral and Maxillofacial Surgery Simon Young, Kyriacos A. Athanasiou, Antonios G. Mikos and Mark Eu-Kien Wong 72. Periodontal-Tissue Engineering Hai Zhang, Hanson K. Fong, William V. Giannobile and Martha J. Somerman PART NINETEEN: RESPIRATORY SYSTEM 73. Progenitor Cells in the Respiratory System Valérie Besnard and Jeffrey A. Whitsett 74. Lungs Anne E. Bishop and Julia A. Polak PART TWENTY: SKIN 75. Cutaneous Stem Cells George Cotsarelis 76. Wound Repair Kaustabh Ghosh and Richard A.F. Clark 77. Bioengineered Skin Constructs Vincent Falanga and Katie Faria PART TWENTY-ONE: CLINICAL EXPERIENCE 78.Current State of Clinical Application Shaun M. Kunisaki and Dario O. Fauza 79. Tissue-Engineered Skin Products Jonathan Mansbridge 80. Tissue-Engineered Cartilage Products David W. Levine 81. Tissue-Engineered Bone Products John F. Kay 82. Tissue-Engineered Cardiovascular Products Thomas Eschenhagen, Herrmann Reichenspurner and Wolfmram-Hubertus Zimmermann 83. Tissue-Engineered Organs Steve J. Hodges and Anthony Atala PART TWENTY-TWO: REGULATION AND ETHICS 84. The Tissue-Engineering Industry Michael J. Lysaght, Elizabeth Deweerd and Ana Jaklenec 85. The Regulatory Path From Concept to Market Kiki B. Hellman 86. Ethical Issues Laurie Zoloth Epilogue Joseph P. Vacanti