Care of the Jaundiced Neonate

Care of the Jaundiced Neonate focuses exclusively on the scientific underpinnings of jaundice, as well as the care of the jaundiced neonate. Edited by three of the field's most respected neonatal care experts, the book uniquely explains how the imbalance between bilirubin production and elimination leads to jaundice'and that hazardous levels of unconjugated bilirubin can cause kernicterus, or brain damage. In addition, you'll find the most current and clinically relevant perspectives on the physiology, genetics, and treatment of neonatal jaundice and related hemolytic conditions.   FEATURES Covers all aspects of neonatal jaundice'from the biochemistry of bilirubin production to kernicterus Begins with an in-depth examination of the complex gene-environment interactions of bilirubin-induced neurotoxicity and its role in neonatal jaundice Surveys bilirubin production and measurement, its various fractions, and the metabolism and transport of bilirubin Selected chapters highlight the physiology and epidemiology of neonatal unconjugated hyperbilirubinemia; bilirubin toxicity; prevention, screening, and postnatal management; phototherapy and other treatments; and prevention-related public policy. Concluding chapter provides an overview of the key issues surrounding the incidence of neonatal jaundice in low-middle income countries Includes informative review of risk assessment and treatment with phototherapy and other modalities provide key approaches to the effective clinical management of neonatal hyperbilirubinemia David K. Stevenson is Harold K. Faber Professor of Pediatrics, Professor of Ob-Gyn, Senior Associate Dean for Academic Affairs, and Vice Dean, Stanford University School of Medicine, Palo Alto, CA; and Director, Charles B. and Ann L. Johnson Center for Pregnancy and Newborn Services, Lucile Packard Children's Hospital at Stanford. M. Jeffrey Maisels is Professor and Chair, Department of Pediatrics, Oakland University William Beaumont School of Medicine; Clinical Professor of Pediatrics, Wayne State University School of Medicine; and Physician-in-Chief, Beaumont Children's Hospital, Royal Oak, MI. Jon F. Watchko is Professor of Pediatrics, Division of Neonatology and Developmental Biology, and Professor of Ob-Gyn, University of Pittsburgh School of Medicine; and Senior Scientist, Magee-Women's Research Institute, Pittsburgh, PA. Table of contents Chapter 1. Genetics of Neonatal Jaundice Chapter 2. Bilirubin Production and Its Measurement Chapter 3. Bilirubin and Its Various Fractions Chapter 4. Bilirubin Metabolism and Transport Chapter 5. Physiology of Neonatal Unconjugated Hyperbilirubinemia Chapter 6. The Epidemiology of Neonatal Hyperbilirubinemia Chapter 7. Bilirubin Toxicity Chapter 8. Hemolytic Disorders and Their Management Chapter 9. Prevention, Screening and Postnatal Management of Neonatal Hyperbilirubinemia Chapter 10. Phototherapy and Other Treatments Chapter 11. Kernicterus Chapter 12. Public Policy to Prevent Severe Neonatal Hyperbilirubinemia Chapter 13. Neonatal Jaundice in Low-Middle-Income Countries