Tumors of the Esophagus and Stomach

This edition of the Fascicle was written to highlight advances in several areas of tumor biology, and more specifically, to help pathologists diagnose diseases more accurately and understand how pathology contributes to clinical treatment in the new age of personalized and targeted therapy. Notable advances described in this publication include: Expansion of our understanding of the pathologic features and molecular pathogenesis of carcinomas of the esophagus and stomach  Discovery of new diseases, such as gastric adenocarcinoma and proximal polyposis syndrome (GAPPS), a special variant of familial adenomatous polyposis, and significant advances in our knowledge regarding the molecular characterization of genetic polyposis syndromes Great expansion in the molecular-pathology correlation, morphologic diversity, classification, and therapeutic options of gastrointestinal stromal tumors (GISTs) Reclassification and refinement of prognostic factors related to neuroendocrine tumors Improvements in the role of cytology in the diagnosis of tumors of the upper gastrointestinal tract.