Coronary Atherosclerosis

Coronary Atherosclerosis: Current Management and Treatment addresses the leading cause of death worldwide - coronary artery disease. Atherosclerosis has a broad range of disease manifestations depending on the degree of the stenosis, and the functional status of the coronary plaque and is a disease cardiologists manage every day. Prevalence of coronary artery disease is increasing as a greater number of people live longer and rising rates of obesity contribute to poor health. Written by an international team of Editors, this new title addresses the pathophysiology of disease, established and novel diagnostic approaches (both invasive and non-invasive), treatment methodologies (including treatment algorithms), and differing perspectives on treatment including future therapies and long term outcomes. It includes every aspect of coronary artery disease and highlights the optimal treatment for different clinical scenarios. Key topics include: * Pharmacology of CAD * Up to date evidence on pathophysiology * Non invasive imaging * Current evidence for risk stratification * Invasive imaging/cutting edge technology * Clinical decision making from clinical field masters Coronary Atherosclerosis: Current Management and Treatment provides a state of the art review of current knowledge to aid specialists, general physicians, and cardiologists in training, in the diagnosis, risk stratification, and management of patients with diverse presentations of coronary atherosclerosis. Chourmouzios Arampatzis, MD, PhD,FESC , Senior Interventional Cardiologist, Interbalkan Medical Center, Thessaloniki, Greece Eugene P. McFadden MB, BCh, BAO, DCH, MRCP(UK), FRCPI, FESC, FACC , Thoraxcenter, Erasmus University Medical Centre, Rotterdam, The Netherlands and Interventional Cardiologist, Cork University Hospital, Wilton, Cork, Ireland Lampros K. Michalis MD , Professor in Cardiology, Department of Cardiology, Medical School, University of Ioannina, Greece Renu Virmani, M.D. , President and Medical Director, CVPath Institute, Inc., Gaithersburg, Maryland, USA Patrick W. Serruys MD , Head of the Interventional Dept., Heartcenter Rotterdam, Rotterdam, The Netherlands CONTENTS * I. The Pathophysiology of Coronary Atherosclerosis 1. Current concepts of plaque formation and the progression of atherosclerosis - Masataka Nakano, MD., Renu Virmani, MD., and Frank D. Kolodgie, PhD * 2. Screening and identifying the high risk individuals in the general population by using traditional risk factors - Gregory Angelo Sgueglia, MD, PhD, Gaetano Antonio Lanza, MD, Filippo Crea, MD * 3. The role of genomics and proteomics in identifying subjects at risk of clinical manifestations of coronary atherosclerosis and their future clinical applications - Carlos L. Alviar MD, Pedro R. Moreno MD * 4. The identification of the patient at risk using biomarkers: Current status and evolving avenues for research - Gerard Pasterkamp, Imo Hoefer, Dominique de Kleijn * 5. Stable and unstable atherosclerotic disease: definitions, clinical manifestations and pathophysiology - John A Ambrose, MD FACC, Joel A. Lardizabal, MD * II. Diagnostic Approach to Coronary Atherosclerosis: Non Invasive Approach 6. Clinical evaluation of the patient with chest pain - Attilio Maseri * 7. Exercise stress testing, stress echocardiography, and scintigraphy: which tool for which patient? - Arend F.L. Schinkel, MD, PhD, and Manolis Bountioukos, MD, PhD, FES * 8. Multislice Computed Tomography: Role in diagnosis and risk stratification - G.J.R. ten Kate MD, MSc, K. Nieman MD, PhD, P.J. de Feyter MD, PhD * 9. Magnetic resonance imaging: Role in diagnosis and risk stratification - Pier Giorgio Masci MD and Jan Bogaert MD PhD * 10. CT-PET: Role in diagnosis and potential to predict the response to revascularization - Marcelo F. di Carli, Dr. Koh * II. Diagnostic Approach to Coronary Atherosclerosis: Invasive Approach 11. From conventional to 3-dimension coronary angiography: potential clinical - Chrysafios Girasis, MD * 12. Fractional flow reserve: Role in guiding clinical decision making [video content also supplied] - Bernard De Bruyne, Aaron Peace, Stylianos A. Pyxaras * 13. Intravascular ultrasound: Role in diagnosis and management [video content also supplied] - Kenji Sakamoto MD; Yasuhiro Honda MD; Peter J. Fitzgerald MD, PhD * 14. Photoacoustic Imaging of Coronary Arteries: current status and potential clinical application - Krista Jansen, Gijs van Soest PhD, Ton van der Steen PhD * 15. Plaque imaging with optical coherence tomography: Current status and potential clinical implications - Francesco Prati, Eleonora Ficarra, Vito Ramazzotti, Mario Albertucci * 16. Thermal assessment of the human coronary atherosclerotic plaque: Current status and potential clinical implications - Konstantinos Toutouzas, Maria Drakopoulou, Archontoula Michelongona, Eleftherios Tsiamis, Christodoulos Stefanadis * 17. Imaging of Structure and Composition of Lipid Core Plaque with a Combination NIRS-IVUS System: Current Status and Potential Clinical Applications - Emmanouil S. Brilakis, MD, PhD, Zhihua He, PhD, Stephen T. Sum, PhD, Sean P. Madden, PhD, James E. Muller, M.D. * 18. Role of Endothelial Shear Stress in the Destabilization of Coronary Plaque: Acute Coronary Syndromes and Rapid Plaque Progression - Antonios P. Antoniadis, MD, PhD, Michail I. Papafaklis, MD, PhD, Saeko Takahashi, MD, Charles L. Feldman, ScD, Peter H. Stone, MD * 19. Tissue characterization using virtual histology and iMAP: Current status and potential clinical applications - Salvatore Brugaletta, MD; Hector M. Garcia-Garcia, MD, PhD * 20. The role of angioscopy in the assessment of the atherosclerotic plaque: Current status and potential clinical applications [video content also supplied] - Yasunori Ueda, MD, PhD; Kazuhisa Kodama, MD, PhD * 21. What is the optimal imaging tool for coronary atherosclerosis? - Takashi Kubo, MD, PhD; Takashi Akasaka, MD, PhD * III. Treatment methodology of coronary artery disease 22. Optimization of primary and secondary prevention - Katerina K. Naka MD, PhD, FESC, ,Aris Bechlioulis MD, Lampros K. Michalis MD, MRCP (UK), FESC * 23. Anti-ischemic pharmacotherapy in patients with established coronary artery disease - Dimitrios Alexopoulos MD, FESC, FACC, Ioanna Xanthopoulou MD * 24. Antithrombotic pharmacotherapy in patients with established coronary artery disease - Antonio Tello-Montoliu, MD, PhD; Dominick J Angiolillo, MD, PhD * 25. Invasive assessment and management of intermediate coronary narrowings - William F. Fearon, M.D. * 26. Treatment algorithm in patients with stable angina - Andrew Cassar, M.D., M.R.C.P. *Bernard J. Gersh, M.B., Ch.B., D.Phil, F.R.C.P. * 27. Treatment algorithm in patients with NSTEMI and unstable angina - Francesco Saia, MD, PhD * 28. Treatment algorithm in patients with STEMI - Luca Golino MD, PhD, Giuseppe De Luca MD, PhD * 29. Management of microvascular angina - Juan Carlos Kaski, MD, DSc, Peter Ong, MD * 30. Treatment algorithm in patients with concomitant heart valve disease - Vassilis Voudris MD FESC FACC, Panagiota Georgiadou MD * IV. Treatment approach to coronary artery disease: Diverse perspectives 31. Clinical Perspectives on the Management of Advanced Stable Coronary Disease - Ranil de Silva PhD FRCP and Kim Fox MD FRCP * 32. Interventional Perspectives on the Management of Advanced Stable Coronary Artery Disease [video content also supplied] - Joanne Shannon MD, Azeem Latib MD, Antonio Colombo MD * 33. Surgical perspectives on the Management of Advanced Stable Coronary Artery Disease - Michael J. Mack MD, Arie Pieter Kappetein, M.D., Ph.D., Stuart Head, MS * 34. Hybrid treatments and future perspectives [video content also supplied] - G. Russell Reiss MD and Mathew R. Williams MD * 35. Determinants of long term outcome following percutaneous coronary intervention - Pedro A. Lemos MD PhD * 36. Determinants of long term outcome following bypass surgery - Arie Pieter Kappetein, M.D., Ph.D., Stuart Head, M.Bsc * 37. Novel therapeutic approaches to prevention and regression of athersclerosis - Kuang-Yuh Chyu, MD, PhD, Prediman K. Shah, MD