Physiology of the Heart

Dr. Arnold Katz's internationally acclaimed classic is now in its thoroughly revised Fifth Edition, incorporating the latest molecular biology research and extensively exploring the clinical applications of these findings. In the single authored, expert voice that is this book's unique strength, Dr. Katz provides a comprehensive overview of the physiological and biophysical basis of cardiac function, beginning with structure and proceeding to biochemistry, biophysics, and pathophysiology in arrhythmias, ischemia, and heart failure. Emphasis is on the interrelationships of basic processes among the cell, cardiac muscle function, and the biophysics of contractile and electrical behavior. This edition includes new material on cell signaling and molecular biology. Contents STRUCTURE, BIOCHEMISTRY, AND BIOPHYSICS Structure of the Heart and Cardiac Muscle Energetics and Energy Production Energy Utilization (Work and Heat) The Contractile Proteins The Cytoskeleton Active State, Length-Tension Relationship, and Cardiac Mechanics Excitation-Contraction Coupling: Extracellular and Intracellular Calcium Cycles SIGNAL TRANSDUCTION AND REGULATION Signal Transduction: Functional Signaling Signal Transduction: Proliferative Signaling Regulation of Cardiac Muscle Performance: Functional and Proliferative Mechanisms NORMAL PHYSIOLOGY The Heart as a Muscular Pump The Working Heart Cardiac Ion Channels The Cardiac Action Potential CLINICAL PHYSIOLOGY The Electrocardiogram Arrhythmias The Ischemic Heart Heart Failure