Focal Therapy in Prostate Cancer

Do you manage patients with prostate cancer? Are you keen on learning more about the very latest form of treatment? Focal therapy represents a potentially huge shift in the way in which men with localized prostate cancer are treated. By targeting and treating only the cancer areas in the gland, it offers a credible alternative to more traditional radical surgery or active surveillance. Focal Therapy in Prostate Cancer provides you with an evidence–based, dynamic and comprehensive review of this exciting new form of treatment, written by an outstanding international team of leading urologists, oncologists, radiologists and pathologists. Well–illustrated throughout, chapters are divided into key sections covering the key questions faced by cancer specialists and patients interested in focal therapy: * Is there a role for focal therapy in localized prostate cancer? * How can we accurately locate cancer within the gland? * How can we create discrete tissue necrosis? * How can we determine the success of focal therapy? No other book goes into such detail or covers the range of different technologies used for this cutting–edge therapy. With expert guidance throughout to help improve your clinical knowledge, Focal Therapy in Prostate Cancer is an essential guide for all training and practicing oncologists, urologists, and radiologists as well as the general physician with a keen interest in cancer care. Table of Contents Section I: Is there a role for Focal Therapy in Localised Prostate Cancer? 1 The Rationale for Focal Therapy of Prostate Cancer (Cole Davis, Matthew Cooperberg and Peter R. Carroll). 2 Factors that affect patients′ choice of treatment (Deb Feldman–Stewart and Michael D. Brundage). 3 Histological Trends and the Index Lesion in Localized Prostate Cancer (Vladimir Mouraviev, Thomas Wheeler and Thomas J. Polascik). 4 Selection Criteria for Prostate Cancer Focal Therapy (Rajat K. Jain, Timothy K. Ito and Samir S. Taneja). Section II: How can we accurately locate cancer within the gland? 5 Localisation of Cancer within the Gland: Biopsy Strategies (Winston E Barzell and Rodrigo Pinochet). 6 Localisation of Cancer within the Gland: Ultrasound Imaging (Ing. U. Scheipers). 7 Localization of cancer within the prostate: dynamic contrast–enhanced Magnetic Resonance Imaging (Philippe Puech, Anwar Padhani, Laurent Lemaitre, Nacim Betrouni, Pierre Colin and Arnauld Villers). 8 Localization of Cancer within the Gland: Diffusion Weighted Magnetic Resonance Imaging of the Prostate (Sophie F Riches, Nina Tunariu and Nandita M deSouza). 9 The future of molecular and biomolecular imaging in prostate cancer (Michael S. Gee and Mukesh G. Harisinghani). Section III: How can we create discrete tissue necrosis? 10 Energies for Focal Ablation: Cryoablation (John F. Ward). 11 Focal Salvage Cryoablation in Recurrent Prostate Cancer (Katsuto Shinohara). 12 Energies for Focal Ablation: High Intensity Focused Ultrasound (Hashim Uddin Ahmed and Mark Emberton). 13 Energies for Focal Ablation: Photodynamic Therapy (Caroline M. Moore, Nimalan Arumainayagam and Mark Emberton). 14 Focal Therapy for Prostate Cancer Using Radiation (Irving Kaplan, Elizabeth Genega and Neil Rofsky). 15 Image Registration and Fusion for Image–Guided Focal Ablation (Dean Barratt and David Hawkes). Section IV: How can we determine the success of Focal Therapy? 16 Determining Success of Focal Therapy: Biochemical and Biopsy Strategies (Al Barqawi MD, Paul Maroni MD, E. David Crawford MD). 17 Determining Success of Focal Therapy: Imaging (Alex Kirkham and Clare Allen). 18 Focal therapy in Localised Prostate Cancer: future perspectives (Hashim Uddin Ahmed and Mark Emberton).