Therapeutic Advances in Thrombosis

Managing patients with thrombotic vascular disease is complex and challenging: Ischemic vascular disease remains a complicated interplay of atherosclerosis and thrombosis—even with the evolution in our understanding of the pathobiology of thrombosis. There has been tremendous growth in therapeutic options which are quickly finding their place in daily practice, including a remarkable expansion in the number of intravenous and oral antithrombotic agents and new antiplatelet agents Now more than ever, all cardiologists, hematologists, and specialists in vascular medicine, as well as other professionals, such as hospital pharmacists, who deal with prognosis and intervention in preventing thrombosis, need a resource that distills current knowledge of this important subject. Written and edited by today’s leading international, Therapeutic Advances in Thrombosis, 2e provides physicians with the very latest in medical and surgical advances in antithrombotic therapies. With this comprehensively updated edition you get: Coverage of virtually all aspects of venous and arterial thrombotic disease and the corresponding therapies Strategies to manage specific clinical conditions and how to tailor treatment to individual patient needs Updated chapters covering thrombolysis in ST-elevated myocardial infarctions; thrombosis in patients with diabetes, pregnancy, and renal dysfunction Special emphasis on the pharmacology of novel anticoagulants and their practical use in venous thromboembolism and atrial fibrillation. Plus, all chapters fully explore clinical trial designs and outcomes for particular treatment therapies, as well as contain the relevant ACC/AHA/ESC guidelines, so you can confidently apply what you learn. CONTENTS 1 Arterial Thrombosis: a brief overview Lina Badimon and Valentin Fuster 2 Aspirin Carlo Patrono 3 Part 1 Platelet ADP P2Y12 Inhibitors - Thienopyridines Joseph D. Foley III, and David J. Moliterno 3 Part 2 Platelet ADP P2Y12 Inhibitors – Non-Thienopyridines Joseph D. Foley III, and David J. Moliterno 4 Cilostazol and Dipyridamole- More than weak inhibition of platelets W.G. Eisert 5 The Inter-relationship of Thrombin and Platelets—The Protease Activated Receptor-1 (PAR-1) Matthew E. Wiisanen and David J. Moliterno 6 Glycoprotein IIb/IIIa inhibitors Marco Valgimigli and Elisa Cangiano 7 Unfractionated heparin and low-molecular-weight heparin in ischemic heart disease Marc Cohen, Omar Hassan and Zafar Iqbal 8 Pentasaccharide derivatives Antonio Gutierrez, Pierluigi Tricoci and John H.P. Alexander 9 Intravenous direct thrombin inhibitors A. Michael Lincoff 10 Vitamin K antagonists Freek W.A. Verheugt 11 Oral direct thrombin inhibitors and oral Xa inhibitors Steen Husted and Lars Wallentin 12 Thrombolytic therapy and concomitant antithrombotic therapies Peter R Sinnaeve and Frans J Van de Werf 13 Antithrombotic therapy in STEMI Kurt Huber, Raffaele De Caterina, Steen Kristensen 14 Antithrombotic Therapy in Non-ST Elevation Acute Coronary Syndromes Georgios J. Vlachojannis , Vijayalakshmi Kunadian, Joseph M. Sweeny and Roxana Mehran 15 Antithrombotic strategies in patients undergoing elective PCI Sunil V. Rao and E. Magnus Ohman 16 ANTITHROMBOTIC MANAGEMENT IN PATIENTSW ITH PROSTHETIC VALVES Eric G Butchart and Raffaele De Caterina 17 Stroke – Thrombolysis and Antithrombotic Therapy L. Creed Pettigrew and Michael R. Dobbs 18 Atrial fibrillation: current and forthcoming antithrombotic therapies Raffaele De Caterina and Giulia Renda 19 Venous thromboembolism: pathophysiology, diagnosis and prophylaxis M.P. Donadini, W. Ageno, A.G.G. Turpie 20 Antithrombotic therapy in venous thrombosis and pulmonary embolism M. Di Nisio and H.R. Büller 21 PREVENTION AND TREATMENT OF VENOUS AND ARTERIAL THROMBOSIS IN PATIENTS WITH SPECIFIC CONDITIONS: DIABETES, HYPERCOAGULABLE STATES, PREGNANCY AND RENAL INSUFFICIENCY Michel Meyer SAMAMA, Jacqueline CONARD and Grigoris GEROTZIAFAS 22 Genetics of the response to antithrombotic drugs and the need for monitoring Jean-Philippe COLLET, Gilles MONTALESCOT and Jean-Sébastien HULOT