Metabolic Risk for Cardiovascular Disease

The relationship of metabolic diseases to cardiovascular disease (CVD) is reaching epidemic proportions. This relates mostly to the increasing prevalence of obesity, the metabolic syndrome and type 2 diabetes. This book outlines and addresses the metabolic factors and related diseases that contribute to CVD, including brief introductions to metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action and body weight regulation. Mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes are also addressed, and the importance of interventions that reduce metabolic risk factors and CVD are covered. CONTENTS Contributors. Preface. Foreword. 1 Insulin Action, Fuel Partitioning, and Body Weight Regulations (Steven Kahn & Kristina M Utzschneider). 2 Lipid and Lipoprotein Metabolism and CVD Risk (Frank Sacks). 3 Tobacco and CVD Risk (C. Barr Taylor). 4 Nutrition and CVD Risk (Alice Lichtenstein). 5 Physical Activity and Cardiovascular Health (William E Kraus & William L Haskell). 6 The obesity Epidemic and CVD Risk (Paul Pointer). 7 Insulin Resistance, the Metabolic Syndrome and CVD Risk (Sidney Smith). 8 Diabetes and CVD Risk (Peter Wilson). 9 Lipid Management and CVD Risk Reduction (Antonio M. Gotto, Jr. & John A Farmer). 10 Obesity Management and CVD Risk Reduction (George Bray). 11 Diabetes Management and CVD Risk Reduction (Jay Skyler). 12 A Healthy Lifestyle and CVD Prevention (Arne Astrup). Index. Author Disclosure Table. ++++++ Robert H. Eckel, M.D. Professor of Medicine Division of Endocrinology, Metabolism and Diabetes Division of Cardiology Professor of Physiology and Biophysics Charles A. Boettcher II Chair in Atherosclerosis Program Director, Adult General Clinical Research Center University of Colorado at Denver and Health Sciences Center Director Lipid Clinic, University Hospital