Malignant Liver Tumors

This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options - radiological, surgical, pharmaceutical, and emerging/novel therapies - and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3 rd Edition, illuminates the path to better patient care. Editor-in-Chief: Pierre-Alain Clavien (Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland) Associate Editors: Tadatoshi Takayama, Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan (CM Lo, Liver Transplant Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong) - R. Chari, Associate Professor of Surgery and Cancer Biology, Division Chief of Hepatobillary Surgery and Liver Transplantation, Staff Surgeon, Veterans Affairs Medical Center, Vanderbilt University Medical Center, Nashville, USA - M. Morse, Associate Professor, Duke University Medical School, Durham, USA - J. Llovet, Barcelona-ClÉnic Liver Cancer Group, Liver Unit, Institut d'Investigacions Biomédiques August Pi I Sunyer, Hospital ClÉnic, University of Barcelona, Catalonia, Spain CONTENTS SECTION 1: Introduction. 1. From Promethean to modern times (Kuno Lehmann, Stefan Breitenstein, Pierre-Alain Clavien). 2 Hepatic anatomy and terminology (Steven M. Strasberg). SECTION 2: Epidemiology and Diagnosis. Introduction (Chung-Mau Lo). 3 Histology and pathology of normal and diseased liver (steatosis, fibrosis, cirrhosis) (Valérie Paradis, Achim Weber). 4 Pathology of primary and secondary malignant liver tumors (Kay Washington). 5 Epidemiology, etiology, and natural history of hepatocellular carcinoma (Wei-Chen Lee, Miin-Fu Chen). 6 Epidemiology, etiology, and natural history of cholangiocarcinoma (Peter Neuhaus, Ulf P. Neumann, Daniel Seehofer). 7 Epidemiology, etiology, and natural history of colorectal liver metastases (Robert J. Porte). 8 Tumor markers in primary and secondary liver tumors (Ketsia B. Pierre, Ravi S. Chari). 9 Modalities for imaging liver tumors (Dominik Weishaupt, Thomas F. Hany). SECTION 3: Systemic and Regional Therapies. Introduction (Ravi S. Chari). 10 Systemic treatment of hepatobiliary tumors (Panagiotis Samaras, Michael A. Morse, Bernhard C. Pestalozzi). 11 External beam radiation therapy for liver tumors (Rakesh Reddy, A. Bapsi Chakravarthy). 12 Internal radiation therapy for liver tumors (Ahsun Riaz, Laura Kulik, Michael Abecassis, Riad Salem). 13 Transarterial embolization for patients with hepatocellular carcinoma (Jordi Bruix, Carmen Ayuso, Maria Isabel Real). 14 Selective continuous intra-arterial chemotherapy for liver tumors (Fidel David Huitzil-Melendez, Stefan Breitenstein, Nancy Kemeny). 15 Isolated hepatic perfusion (Charles K. Heller, III, James F. Pingpank, Steven K. Libutti). SECTION 4: Resection, Ablation or Transplantation for Liver Tumors. Introduction (Jean-Nicolas Vauthey, Tadatoshi Takayama). 16 Liver resection of primary tumors: hepatocellular carcinoma, cholangiocarcinoma, gallbladder cancer (Tadatoshi Takayama, Masatoshi Makuuchi). 17 Liver resection of colorectal liver metastases (Daria Zorzi, Yun Shin Chun, Jean-Nicolas Vauthey). 18 Laparoscopic liver resection (Luca Vigano, Daniel Cherqui). 19 Repeat resection for liver tumors (Mickael Lesurtel, Henrik Petrowsky). 20 Cryoablation of liver tumors (Sivakumar Gananadha, David Lawson Morris). 21 Thermal ablation of liver tumors by radiofrequency, microwave, and laser therapy (M.B. Majella Doyle, David C. Linehan). 22 Ethanol and other percutaneous injection modalities in the treatment of liver tumors (Michael A. Heneghan, Andrew D. Yeoman). 23 Transplantation for liver tumors (François Durand, Claire Francoz, Jacques Belghiti). 24 Preventing recurrence of hepatocellular carcinoma after curative resection (Stefan Breitenstein, Dimitris Dimitroulis, Beat Müllhaupt). SECTION 5: Guidelines for Liver Tumor Treatment. Introduction (Stefan Breitenstein,  Pierre-Alain Clavien). 25 Strategies for safer liver surgery (Philipp Dutkowski, Olivier de Rougemont, Pierre-Alain Clavien). 26 Hepatocellular carcinoma (Tadatoshi Takayama, Josep M. Llovet 27 Cholangiocellular carcinoma (Jacques Belghiti, Charles B. Rosen). 28 Gallbladder cancer (Juan Hepp, Chung-Mau Lo). 29 Colorectal liver metastases (Phuong L. Doan, Jean-Nicolas Vauthey, Martin Palavecino, Michael A. Morse). SECTION 6: Emerging Therapies. Introduction (Michael Morse, Josep M. Llovet). 30 Viral-based therapies for primary and secondary liver cancer (Menghua Dai, Lorena Gonzalez, Yuman Fong). 31 Signaling pathways and rationale for molecular therapies in hepatocellular carcinoma (Augusto Villanueva, Clara Alsinet, Josep M. Llovet). 32 Novel therapies targeted at sinal transduction in liver tumors (Fidel David Huitzil-Melendez, Ghassan K. Abou-Alfa, Michael A. Morse) 33 Induction of apoptosis in liver tumors (Markus Selzner, Pierre-Alain Clavien). 34 Antiangiogenic agents for liver tumors (J. Mathijs Vogten, Emile E. Voest, Inne H.M. Borel Rinkes). 35 Integrative oncology: Alternative and complementary treatments (Barrie R. Cassileth, Jyothirmai Gubili). SECTION 7: Special Tumors, Population and Special Considerations. Introduction (Stefan Breitenstein, Pierre-Alain Clavien). 36 Liver metastases from endocrine tumors (Clayton D. Knox, C. Wright Pinson) 37 Uncommon primary and metastatic liver tumors (Stefan Breitenstein, Ashraf Mohammad El-Badry,  Pierre-Alain Clavien) 38 Liver tumors in special populations (Tadahiro Uemura, Akhtar Khan, Zakiyah Kadry). 39 Treatment of liver tumors in children (Xavier Rogiers, Ruth De Bruyne). 40 Liver tumors in Asia (Norihiro Kokudo, Sumihito Tamura, Masatoshi Makuuchi) 41 Liver tumors in South America (Lucas McCormack, Eduardo de Santibañes). 42 Liver tumors in Africa (Michael C. Kew). 43 Anesthetic management of liver surgery (Marco P. Zalunardo). 44 Qualitative and economical aspects in liver surgery (René Vonlanthen, Ksenija Slankamenac, Christian Ernst).