Pediatric Hematology

Pediatric Hematology is a comprehensive and succinct referenced text on the diagnosis and treatment of blood diseases in childhood. It provides a ready source of reference for all the conditions likely to be encountered in day-to-day clinical practice. For each condition, the authors give helpful advice on differential diagnoses and clinical management. This third edition has been extensively updated throughout, in light of recent developments in this rapidly advancing area of medicine. A well established textbook on the diagnosis and treatment of blood disorders in childhood A balanced and cutting edge referenced text on all aspects of diagnosis and treatment Easy to use, practically organized, with essential aspects of biology included within each chapter International editorial and contributor team - representing a wide geographical and chronological range Whether you are an established sub-specialist in pediatric hematology/oncology, a pediatrician, a trainee or nursing specialist, this book will answer all your questions about benign and malignant disorders of the blood in children and young adults. CONTENTS Section 1: The Scientific Basis 1 Hematopoiesis: an introduction Section 2: Marrow Failure Syndromes 2 Failure of red cell production 3 Inherited bone marrow failure syndromes 4 Acquired aplastic anemia Section 3: Red Cell Disorders 5 Disorders of iron metabolism: iron deficiency, iron overload and the sideroblastic anemias 6 Megaloblastic anemia and disorders of cobalamin and folate metabolism 7 Nonimmune neonatal anemias 8 Immune hemolytic anemias 9 Disorders of erythrocyte metabolism including porphyria 10 Sickle cell disease 11 Hemoglobin variants and the rarer hemoglobin disorders 12 Red cell membrane abnormalities 13 Thalassemias Section 4: Granulocyte Disorders 14 Disorders of granulopoiesis and granulocyte function 15 Histiocytic disorders 16 Acute myeloid leukemia 17 Chronic myeloid leukemia 18 Myelodysplastic syndromes Section 5: Lymphocyte Disorders 19 Primary and acquired immunodeficiency 20 Clinical features and therapy of lymphoblastic leukemia 21 Lymphomas Section 6: Platelet Disorders 22 Inherited and congenital thrombocytopenia 23 Idiopathic thrombocytopenic purpura 24 Thrombocytosis 25 Platelet function disorders Section 7: Coagulation Disorders 26 Hemophilia A and B 27 von Willebrand disease 28 Rare congenital hemorrhagic disorders 29 Acquired disorders of hemostasis 30 Bleeding in the neonate 31 Thromboembolic complications in children Section 8: Supportive Therapy 32 Blood components and fractionated plasma products: preparation, indications and administration 33 Hazards of transfusion 34 Management of infection in children with bone marrow failure Section 9: Secondary Problems 35 Hematologic effects of systemic disease and nonhematopoietic tumors 36 Lysosomal storage disorders 37 Reference values Professor Robert Arceci edits the main Paediatric Haematology and Oncology journal, 'Pediatric Blood & Cancer' and his research is mainly into new agents for leukaemia therapy and the scientific basis for their actions. Professor Ian Hann is chair of the national NRCN task force on ALL. He is associate medical director of Great Ormond Street Hospital (GOS) and Professor and academic lead in Paediatric Haematology and Oncology at GOS and the Institute of Child Health. Professor Owen Smith is academic lead for Paediatric Haematology and Oncology at the National Children's Hospital, Dublin