This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis and treatments. They also discuss long-term complications, such as second malignancies and cardiovascular complications. Chapters are written by leading world experts, carefully edited to achieve a uniform and accessible writing style. Each chapter includes evidence-based explanations and state-of-the-art solutions, providing the reader with practice-changing advice. Full reference lists are also supplied to facilitate further exploration of each topic. Each copy of the printed book is packaged with a password, giving readers online access to all text and images. This inspiring resource demystifies both the basics and subtleties of hematopoietic cell transplantation, and is essential reading for both senior clinicians and trainees.
Adopts an evidence-based approach to topics and problems, allowing readers to separate factual solutions from empiricism
Chapters are uniform in style throughout, providing a consistent and user-friendly resource while also allowing readers to benefit from the authors' and editors' wealth of experience
Controversies and challenges are clearly explained, enabling and inspiring readers to contribute to the science and practice of hematopoietic cell transplantation
Table of Contents
Part I. Recipient Selection for Hematopoietic Cell Transplantation
Part II. Donor Selection for Allogeneic Hematopoietic Cell Transplants
Part III. Collecting and Processing of the Graft
Part IV. Early Posttransplant Interval
Part V. Infections after Hematopoietic Cell Transplantation – Progress?
Part VI. Late Complications of Hematopoietic Cell Transplantation
Part VII. Other Complications of Hematopoietic Cell Transplants
Part VIII. Prevention, Detection and Treatment of Relapse after Hematopoietic Cell Transplants
Part IX. Selection of Conditioning Regimen and Challenges with Different Types of T-Cell Depletion Methods
Part X. Hematopoietic Cell Transplants for Acute Leukemia and Myelodysplastic Syndrome
Part XI. Hematopoietic Cell Transplants for Myeloproliferative Neoplasms
Part XII. Hematopoietic Cell Transplants for Lymphomas – Changing Indications
Part XIII. Plasma Cell Dyscrasias
Part XIV. Autotransplants for Solid Neoplasms
Part XV. Hematopoietic Cell Transplants for Non-Neoplastic Diseases
Part XVI. Novel Transplant Strategies
Part XVII. Novel Cell Therapies and Manipulations.
Hillard M. Lazarus, Case Western Reserve University, Ohio
Hillard M. Lazarus is Professor of Medicine at the Case Comprehensive Cancer Center, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland.
Robert Peter Gale, Imperial College London
Robert Peter Gale is a Visiting Professor at the Haematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London.
Armand Keating, University of Toronto
Armand Keating is Professor of Medicine and Biomedical Engineering at the University of Toronto, and Director of the Cell Therapy Program, Princess Margaret Cancer Centre, Toronto.
Andrea Bacigalupo, Ospedale San Martino, Genoa
Andrea Bacigalupo is a Professor at the Cattedra Ematologia, Universita' Cattolica del Sacro Cuore, Fondazione Policlinico Unviersitario A Gemelli, Roma-Italia.
Reinhold Munker, Louisiana State University, Shreveport
Reinhold Munker is Professor of Medicine at Louisiana State University.
Kerry Atkinson, University of Queensland
Kerry Atkinson is Adjunct Professor at the University of Queensland Centre for Clinical Research; Adjunct Professor at the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute; and Specialist in General Medicine at Salisbury Medical Centre, Brisbane.
Associate Editor
Syed Ali Abutalib, Midwestern Regional Medical Center, Cancer Treatment Centers of America, Chicago
Syed Ali Abutalib is Assistant Director of the Hematology and Bone Marrow Transplant Program, Cancer Treatment Centers of America, Zion, Illinois.
Contributors
Robert Peter Gale, Shaun McCann, Anita D'Souza, Marcelo Pasquini, Zhiwei Wang, J. Douglas Rizzo, Sergio A. Giralt, Mohamed Sorror, Marcie Riches, Rebecca Olin, Andrew Artz, Mary Eapen, Stephen Spellman, Stefan O. Ciurea, Marcelo A. Fernandez-Vina, John F. DiPersio, Adrian P. Gee, Nelson J. Chao, Ernest Holler, Juergen Finke, Ronald Mertelsmann, Shanna Morgan, Dawn Ward, Jeffrey McCullough, Corrado Girmenia, Claudio Viscoli, Per Ljungman, Lakshmikanth Katragadda, John R. Wingard, Iskra Pusic, Steve Z. Pavletic, Lode J. Swinnen, E. Carreras, Aurore Saudemont, Stephane Eeckhoudt, Alejandro Madrigal, Marcos de Lima, Elisabeth Paietta, Mark Litzow, Francesco Dazzi, Sebastian Mayer, Koen van Besien, Charles Craddock, Sarah A. Buckley, J. M. Pagel, Robert Soiffer, Melody Smith, Miguel-Angel Perales, S. Dobrozsi, Bruce M. Camita, Michelle Poon, Partow Kebriaei, Netanel Horowitz, Jacob Rowe, Masumi Ueda, Martin Tallman, Hillard M. Lazarus, Natasha Kekre, Coleman Lindsley, John Koreth, Andrew J. Innes, Jane Apperley, Nicolaus Kröger, Paolo Caimi, Alex Herrera, Ted Alyea, III, Veronika Bachanova, Robert F. Cornell, Linda J. Burns, Vijaya R. Bhatt, James O. Armitage, Gregory R. Bociek, Sai Ravi Pingali, Timothy Fenske, Lori Muffly, Sonali Smith, Francesco d'Amore, Thomas Relander, Grete F. Lauritzsen, Esa Jantunen, Susanna Mannisto, Peter Meyer, Fredrik Ellin, Martin B. Pedersen, Helle Toldbod, Andy I. Chen, Richard Maziarz, Jesus San Miguel, Sarah Holstein, Phil McCarthy, Thomas Giever, Parameswaran Hari, Taimur Sher, Morie Gertz, Craig Nichols, Christian Kollmansberger, Lawrence Einhorn, Gregory Hale, Jakob R. Passweg, Carlo Dufour, Guido Lucarelli, John Tisdale, Marcelo Pasquini, Despina Moshous, Benedicte Neven, Alaine Fischer, Amrita Krishnan, Andrea Bacigalupo, Karen Ballen, Asad Bashey, Sarwish Rafiq, Renier J. Brentjens, Dean Anthony Lee, Catherine Bollard, John Barrett, Rohtesh Mehta, Katayoun Rezvani, Elizabeth J. Shpall, Hua Fung, Stanton L. Gerson, Kerry Atkinson, Helen Leather, Nandita Khera, Navneet Majhail, Armand Keating
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