Table of Contents
1. Historical Principles and Perspectives
Paul M. Wax
2. Toxicologic Misfortunes and Catastrophes in History
Paul M. Wax
PART A
THE GENERAL APPROACH TO THE PATIENT
3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes
Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman
4. Principles of Managing the Acutely Poisoned or Overdosed Patient
Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions]
SC1. Principles of Antidote Stocking
[Insert author(s)]
5. Decontamination Principles: Prevention of Gastrointestinal Absorption
Lotte C. G. Hoegberg and Anne-Bolette Gude
SC2. Decontamination Principles: Prevention of Dermal, Inhalational and Ocular Absorption
[Insert author(s)]
A1. Activated Charcoal
Silas W. Smith and Mary Ann Howland
A2. Whole-Bowel Irrigation and Other Intestinal Evacuants
Silas W. Smith and Mary Ann Howland
6. Principles and Techniques Applied to Enhance Elimination
David S. Goldfarb and Marc Ghannoum
7. Laboratory Principles
Petrie M. Rainey
8. Principles of Diagnostic Imaging
David T. Schwartz
9. Pharmacokinetic and Toxicokinetic Principles
Mary Ann Howland
PART B
THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY
SECTION I
BIOCHEMICAL AND MOLECULAR CONCEPTS
10. Chemical Principles
Stephen J. Traub and Lewis S. Nelson
11. Biochemical and Metabolic Principles
Kurt C. Kleinschmidt and Kathleen A. Delaney
12. Fluid, Electrolyte, and Acid–Base Principles
Alan N. Charney and Robert S. Hoffman
13. Neurotransmitters and Neuromodulators
Steven C. Curry, Ayrn D. O’Connor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik
14. Withdrawal Principles
Richard J. Hamilton and [new author]
SECTION II
PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS
15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles
Cathleen Clancy
16. Cardiologic Principles II: Hemodynamics
[new author] and Robert A. Hessler
17. Dermatologic Principles
Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson
SC3. Transdermal Toxicology
Lewis S. Nelson
18. Gastrointestinal Principles
Matthew D. Zuckerman and Richard J. Church
19. Genitourinary Principles
Jason Chu
20. Hematologic Principles
Marco L.A. Sivilotti
21. Hepatic Principles
Kathleen A. Delaney
22. Neurologic Principles
Rama B. Rao
23. Oncologic Principles
Richard Wang
24. Ophthalmic Principles
Adhi Sharma
25. Otolaryngologic Principles
[new author] and William Chiang
26. Psychiatric Principles
Erin A. Zerbo and Andrea M. Kondracke
27. Renal Principles
Marc Ghannoum and David S. Goldfarb
28. Respiratory Principles
Andrew Stolbach and Robert S. Hoffman
29. Thermoregulatory Principles
Susi U. Vassallo and Kathleen A. Delaney
SECTION III
SPECIAL POPULATIONS
30. Reproductive and Perinatal Principles
Jeffrey S. Fine
31. Pediatric Principles
Jeffrey S. Fine
32. Geriatric Principles
Judith C. Ahronheim and Mary Ann Howland
PART C
THE CLINICAL BASIS OF MEDICAL TOXICOLOGY
SECTION I
A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS
Case Study 1
33. Acetaminophen
Robert G. Hendrickson
A3. N-Acetylcysteine
Robert G. Hendrickson and Mary Ann Howland
34. Colchicine, Podophyllin, and the Vinca Alkaloids
Joshua G. Schier
35. Nonsteroidal Antiinflammatory Drugs
William J. Holubek
36. Opioids
Lewis S. Nelson and Dean Olsen
A4. opioid antagonists
Lewis S. Nelson and Mary Ann Howland
SC4. Internal Concealment of Xenobiotics
Jane M. Prosser
SC5. Harm Reduction for Opioid Overdose
?Josh Lee
37. Salicylates
Daniel M. Lugassy
A5. sodium bicarbonate
Paul M. Wax
B. Food, Diet, and Nutrition
CASE STUDY 2
38. Botulism
Howard L. Geyer
A6. botulinum antitoxin
Silas W. Smith and Howard L. Geyer
39. Food Poisoning
[new author]and Michael Tunik
40. Dieting Xenobiotics and Regimens
Jeanna M. Marraffa
41. Athletic Performance Enhancers
Susi U. Vassallo
42. Essential Oils
Lauren Kornreich Shawn
43. Herbal Preparations
[new author] and Oliver Hung
44. Vitamins
Beth Y. Ginsburg
45. Iron
Jeanmarie Perrone
A7. deferoxamine
Mary Ann Howland
C. pharmaceuticals
case study 3
46. Pharmaceutical Additives
Sean P. Nordt and Lisa E. Vivero
47. Antidiabetics and Hypoglycemics/Antiglycemics
George M. Bosse
A8. Dextrose (d-Glucose)
[new author] and Larissa Velez
A9. octreotide
Mary Ann Howland and Silas W. Smith
48. Antiepileptics
Suzanne Doyon
A10. l-carnitine
Mary Ann Howland
49. Antihistamines and Decongestants
Sophie Gosselin
A11. physostigmine salicylate
Mary Ann Howland
50. Chemotherapeutics
Richard Y. Wang
51. Methotrexate, 5-Flourouracil, and Capecitabine
Richard Y. Wang
A12. folates: leucovorin (Folinic acid) and Folic Acid
Mary Ann Howland
A13. glucarpidase (carboxypeptidase g2)
Silas W. Smith
A14. uridine triacetate
Silas W. Smith
SC6. Inadvertent Intrathecal Administration of Xenobiotics
Rama B. Rao
SC7. Extravasation of Chemotherapeutics
Richard Y. Wang
52. Antimigraine Medications
Jason Chu
53. Thyroid and Antithyroid Medications
Nicole C. Bouchard
D. Antimicrobials
54. Antibacterials, Antifungals, and Antivirals
Christine M. Stork
55. Antimalarials
James David Barry
56. Antituberculous Medications
Christina H. Hernon
A15. pyridoxine
Mary Ann Howland
E. Cardiopulmonary Medications
CASE STUDY 4
57. Antidysrhythmics
Lewis S. Nelson
A16. Magnesium Sulfate
Silas Smith
58. Antithrombotics
Betty C. Chen and Mark Su
A17. Protein Complex Concentrate and novel Antithrombotic Antidotes
[Insert author(s)], Betty Chen and Mark Su
A18. Vitamin k1
Mary Ann Howland
A19. protamine
Mary Ann Howland
59. β-Adrenergic Antagonists
Jeffrey R. Brubacher
A20. Glucagon
Mary Ann Howland
60. Calcium Channel Blockers
David H. Jang and Francis Jerome DeRoos
A21. High-dose insulin euglycemia
Samuel J. Stellpflug and William Kerns, II
61. Miscellaneous Antihypertensives and Pharmacologically Related Agents
Francis Jerome DeRoos
62. Cardioactive Steroids
Jason B. Hack
A22. digoxin-specific antibody fragments
Mary Ann Howland
63. Methylxanthines and Selective β2-Adrenergic Agonists
Robert J. Hoffman
F. ANESTHETICS AND RELATED MEDICATIONS
64. Local Anesthetics
David R. Schwartz and Brian Kaufman
A23. intravenous lipid emulsion
[new author] and Todd Bania
65. Inhalational Anesthetics
Brian Kaufman
66. Neuromuscular Blockers
Kenneth M. Sutin
A24. dantrolene sodium
Kenneth M. Sutin
A25. Sugammadex
[new; Author]
G. Psychotropics
CASE STUDY 5
67. Antipsychotics
David Juurlink
68. Cyclic Antidepressants
Erica L. Liebelt
69. Serotonin Reuptake Inhibitors and Atypical Antidepressants
Christine M. Stork
70. Lithium
Howard A. Greller
71. Monoamine Oxidase Inhibitors
Alex F. Manini
72. Sedative-Hypnotics
David C. Lee
A26. flumazenil
Mary Ann Howland
H. SUBSTANCES OF ABUSE
CASE STUDY 6
73. Amphetamines
David H. Jang
74. Cannabinoids
Jeff M. Lapoint
75. Cocaine
Jane M. Prosser and Robert S. Hoffman
A27. Benzodiazepines
Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland
76. Ethanol
Luke Yip
A28. Thiamine hydrochloride
Robert S. Hoffman
77. Ethanol Withdrawal
Jeffrey A. Gold and Lewis S. Nelson
78. Disulfiram and Disulfiram-like Reactions
Amit K. Gupta
79. Hallucinogens
Jennifer L. Carey and Kavita M. Babu
80. γ-Hydroxybutyric Acid (γ-Hydroxybutyrate)
Brenna M. Farmer
81. Inhalants
Heather Long
82. Nicotine
[New author] and Sari Soghoian
83. Phencyclidine and Ketamine
Ruben E. Olmedo
I. Metals
CASE STUDY 7
84. Aluminum
Brenna M. Farmer
85. Antimony
Asim F. Tarabar
86. Arsenic
Stephen W. Munday
A29. Dimercaprol (british anti-lewisite or bal)
Mary Ann Howland
87. Bismuth
Rama B. Rao
88. Cadmium
Stephen J. Traub and Robert S. Hoffman
89. Cesium
Zhanna Livshits
90. Chromium
Steven B. Bird
91. Cobalt
Gar Ming Chan
92. Copper
Lewis S. Nelson
93. Lead
Diane P. Calello and Fred M. Henretig
A30. succimer (2,3-dimercaptosuccinic acid)
Mary Ann Howland
A31. edetate calcium disodium (CaNa2EDTA)
Mary Ann Howland
94. Manganese
[New author] and Sari Soghoian
95. Mercury
Young-Jin Sue
96. Nickel
John A. Curtis and David A. Haggerty
97. Selenium
Diane P. Calello
98. Silver
Melisa W. Lai Becker and Michele M. Burns
99. Thallium
Maria Mercurio-Zappala and Robert S. Hoffman
A32. Prussian blue
Robert S. Hoffman
100. Zinc
Nima Majlesi
J. HOUSEHOLD PRODUCTS
CASE STUDY 8
101. Antiseptics, Disinfectants, and Sterilants
Paul M. Wax
102. Camphor and Moth Repellents
Hong K. Kim
103. Caustics
Jessica A. Fulton
104. Hydrofluoric Acid and Fluorides
Mark Su
A33. Calcium
Mary Ann Howland
105. Hydrocarbons
[new author] and David D. Gummin
106. Toxic Alcohols
Sage W. Wiener
A34. fomepizole
Mary Ann Howland
A35. ethanol
Mary Ann Howland
SC8. Diethylene Glycol
Joshua G. Schier
K. PESTICIDES
CASE STUDY 9
107. Barium
Andrew Dawson
108. Fumigants
Shahin Shadnia
109. Herbicides
Darren M. Roberts
110. Insecticides: Organic Phosphorus Compounds and Carbamates
Michael Eddleston
A36. Atropine
Mary Ann Howland
A37. Pralidoxime
Mary Ann Howland
111. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents
Michael G. Holland[LG1]
112. Phosphorus
Michael C. Beuhler
113. Sodium Monofluoroacetate and Fluoroacetamide
Fermin Barrueto Jr.
114. Strychnine
Yiu-Cheung Chan
L. Natural Toxins and Envenomations
CASE STUDY 10
115. Arthropods
[new author] and In-Hei Hahn
A38. antivenom: spider
Michael A. Darracq and Richard F. Clark
A39. antivenom: scorpion
Michael A. Darracq and Richard F. Clark
116. Marine Envenomations
Eric Brush
117. Mushrooms
Lewis R. Goldfrank
118. Plants
Lewis S. Nelson and Lewis R. Goldfrank
119. Native (US) Venomous Snakes and Lizards
Anne-Michelle Ruha and Anthony F. Pizon
A40. antivenom: snakes (native [US] venomous [crotaline and elapid])
Anthony F. Pizon and Anne-Michelle Ruha
SC9. Exotic Nonnative Snake Envenomations
Keith Boesen, Kelly A. Green Boesen, and Farshad “Mazda” Shirazi
M. OCCUPATIONAL AND ENVIRONMENTAL TOXINS
CASE STUDY 11
120. Smoke Inhalation
Nathan P. Charlton and Mark A. Kirk
121. Simple Asphyxiants and Pulmonary Irritants
Lewis S. Nelson and Oladapo A. Odujebe
122. Carbon Monoxide
Christian Tomaszewski
A41. hyperbaric oxygen
Stephen R. Thom
123. Cyanide and Hydrogen Sulfide
Christopher P. Holstege and Mark A. Kirk
A42. hydroxocobalamin
Mary Ann Howland
A43. sodium nitrite, amyl nitrite and sodium thiosulfate
Mary Ann Howland
124. Methemoglobin Inducers
Dennis P. Price
A44. methylene blue
Mary Ann Howland
125. Nanotoxicology
Silas W. Smith
N. DISASTER PREPAREDNESS
126. Chemical Weapons
Jeffrey R. Suchard
127. Biological Weapons
Jeffrey R. Suchard
128. Radiation
Joseph G. Rella
A45. Potassium iodide
Joseph G. Rella
A46. Pentetic acid or pentetate (zinc or calcium) trisodium (dtpa)
Joseph G. Rella
part D
POPULATION HEALTH
section 1
POISON CENTERS, health systems, AND EPIDEMIOLOGY
CASE STUDY 12
129. Poison Prevention and Education
Lauren Schwartz
130. Poison Centers and Poison Epidemiology
Mark Su
131. Industrial Poisoning: Information and Control
Peter H. Wald
132. Hazardous Materials Incident Response
[new author]
133. Risk Assessment and Risk Communication
Charles A. McKay
134. Medication Safety and Adverse Drug Events
Brenna M. Farmer
135. Drug Development, Adverse Drug Events, and Postmarketing Surveillance
Louis R. Cantilena
136. International Perspectives on Medical Toxicology
Sari Soghoian
137. Principles of Epidemiology and Research Design
Alex F. Manini and Kevin C. Osterhoudt
Section II
LEGAL ASPECTS OF TOXICOLOGY
138. Risk Management and Legal Principles
Barbara M. Kirrane and Dainius A. Drukteinis
139. Medicolegal Interpretive Toxicology
Robert A. Middleberg
SC10. Assessment of Ethanol-Induced Impairment
Robert B. Palmer
140. Postmortem Toxicology
Rama B. Rao and Mark A. Flomenbaum
SC11. Organ Procurement from Poisoned Patients
Rama B. Rao
bsp;
134. Medication Safety and Adverse Drug Events
Brenna M. Farmer
135. Drug Development, Adverse Drug Events, and Postmarketing Surveillance
Louis R. Cantilena
136. International Perspectives on Medical Toxicology
Sari Soghoian
137. Principles of Epidemiology and Research Design
Alex F. Manini and Kevin C. Osterhoudt
Section II
LEGAL ASPECTS OF TOXICOLOGY
138. Risk Management and Legal Principles
Barbara M. Kirrane and Dainius A. Drukteinis
139. Medicolegal Interpretive Toxicology
Robert A. Middleberg
SC10. Assessment of Ethanol-Induced Impairment
Robert B. Palmer
140. Postmortem Toxicology
Rama B. Rao and Mark A. Flomenbaum
SC11. Organ Procurement from Poisoned Patients
Rama B. Rao
