Antibiotic Drug Resistance

This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases.

    Provides readers with knowledge about the broad field of drug resistance
    Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases
    Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Table of contents

List of Contributors

Preface

Part I: Current antibiotics and their mechanism of action

Chapter 1: Resistance to aminoglycosides: glycomics and the link to the Human gut microbiome

Chapter 2: Mechanisms of action and of resistance to quinolones

Chapter 3: Betalactams

Chapter 4: Glycopeptide antibiotics: Mechanism of action and recent developments

Chapter 5: Current macrolide antibiotics and their mechanisms of action

Part II: Mechanism of antibiotic resistance

Chapter 6: Impact of key and secondary drug resistance mutations on structure and activity of β-lactamases

Chapter 7: Acquired resistance from gene transfer

Chapter 8: Antimicrobial efflux pumps

Chapter 9: Bacterial persistence in biofilms and antibiotics: mechanisms involved

Part III: Socio-economical perspectives and impact of AR

Chapter 10: Sources of antibiotic resistance – zoonotic, human, environment

Chapter 11: Antibiotic Resistance – immunity, acquired resistance: Evolution of antimicrobial resistance among extended-spectrum β-lactamases and Carbapenemases in Klebsiella pneumoniae and Escherichia coli

Chapter 12: Prevalence of AR – world map: Overview of Extended-Spectrum-β-Lactamase and Carbapenemase -Producing Enterobacteriaceae in Food-Producing Animals in Europe. A Impact on Public Health?

Part IV: Therapeutic Strategy for overcoming AR

Chapter 13: AR mechanism based drug design

Chapter 14: Antibiotics from natural sources

Chapter 15: Bacteriophage proteins as antimicrobials to combat antibiotic resistance

Chapter 16: Antibiotics modification addressing resistance

Chapter 17: Sensitizing agents to restore antibiotic activity

Chapter 18: Repurposing antibiotics to treat resistant gram-negative pathogens

Chapter 19: Non-traditional medicines for treatment of AR

Chapter 20: Therapeutic options for treatment of infections by pathogenic biofilms

Part V: Strategies to prevent the spread of AR

Chapter 21: Rapid analytical methods to identify AR bacteria

Chapter 22: Effective methods for disinfection and sterilization

Chapter 23: Strategies to prevent the spread of antibiotic resistance: understanding the role of antibiotics in nature and their rational use

Part VI: Public policy

Chapter 24: Strategies reduce or eliminate resistant pathogen in the environment

José-Luis Capelo Martinez, PhD, is Assistant Professor in the Chemistry Department of the Faculty of Science and Technology of the New University of Lisbon.

Gilberto Igrejas PhD, is an Associate Professor with habilitation at the University of Trás-os-Montes and Alto Douro in Portugal.