Clinical Reproductive Science

The comprehensive and authoritative guide to clinical reproductive science

The field of clinical reproductive science continues to evolve; this important resource offers the basics of reproductive biology as well as the most recent advance in clinical embryology. The author - a noted expert in the field - focuses on the discipline and covers all aspects of this field. The text explores causes of male and female infertility and includes information on patient consultation and assessment, gamete retrieval and preparation, embryo culture, embryo transfer and cryopreservation.

Comprehensive in scope, the text contains an introduction to the field of clinical reproductive science and a review of assisted reproductive technology. The author includes information on a wide range of topics such as gonadal development, the regulation of meiotic cell cycle, the biology of sperm and spermatogenesis, in vitro culture, embryo transfer techniques, fundamentals of fertilisation, oocyte activation and much more. This important resource:

Offers an accessible guide to the most current research and techniques to the science of clinical reproduction
Covers the fundamental elements of reproductive science
Includes information on male and the female reproductive basics – everything from sexual differentiation to foetal development and parturition
Explores the long-term health of children conceived through IVF
Contains the newest developments in assisted reproductive technology
Clinical Reproductive Science is a valuable reference written for professionals in academia, research and clinical professionals working in the field of reproductive science, clinical embryology and reproductive medicine. 

CONTENTS

Section One Reproductive Science: Fundamentals of Human Reproductive Biology 1

1 Sexual Differentiation, Gonadal Development, and Development of the External Genitalia: A Review of The Regulation of Sexual Differentiation 3
Rebecca M. Perrett

2 Male and Female Reproductive Anatomy 35
Sara Sulaiman and James Coey

3 Fundamentals of Reproductive Endocrinology 45
Derrick Ebot, Haider Hilal, Michael Carroll, and James Coey

4 The Ovaries, Oocytes, and Folliculogenesis 57
Jacques Gilloteaux and James Coey

5 The Human Spermatozoa 65
Allan Pacey and Katrina Williams

6 The Biology of Fertilization 75
Michael Carroll

7 Human Embryo Development: From Zygote Stage to Peri‐Implantation Blastocyst 93
Stéphane Berneau and Michael Carroll

8 The Female Reproductive Tract and Early Embryo Development: A Question of Supply and Demand 99
Henry J. Leese and Daniel R. Brison

Section Two Clinical Reproductive Science: Causes of Male and Female Infertility 109

9 Disorders of Male Reproductive Endocrinology 111
Michael Carroll

10 Disorders of Female Reproductive Endocrinology 125
Mahshid Nickkho‐Amiry and Cheryl T. Fitzgerald

11 Oocyte Aneuploidy and the Maternal Age Effect 133
Mary Herbert

12 Female Reproductive Pathology: Peritoneal, Uterine, and Fallopian Tube Pathologies 147
Kenneth Ma Kin Yue, Rosa Trigas, and Edmond Edi‐Osagie

13 Pathologies of the Male Reproductive Tract 159
Aarush Sajjad, Muhammad A. Akhtar, and Yasmin Sajjad

14 The Impact of Infections on Reproduction and Fertility 177
Val Edwards Jones

15 Nutrition, Fetal Health, and Pregnancy 189
Emma Derbyshire

16 The Embryonic Environment and Developmental Origins of Health 195
Tom P. Fleming and Congshan Sun

17 Lifestyle and Environmental Impacts on Fertility 205
Ana‐Maria Tomova and Michael Carroll

Section Three Clinical Reproductive Science In Practice: IVF and Assisted Reproductive Technologies 215

18 Assessing the Infertile Couple 217
Narmada Katakam, Ruth Arnesen, Caroline Watkins, Bert Stewart, and Luciano G. Nardo

19 Ovarian Stimulation Protocols 231
Nikolaos Tsampras and Cheryl T. Fitzgerald

20 Oocyte Retrieval Techniques and Culture of Oocytes 241
Dawn Yell

21 Sperm Preparation: Strategy and Methodology 251
Stephen Harbottle

22 Diagnostic Semen Analysis: Uncertainty, Clinical Value, and Recent Advances 265
Mathew Tomlinson

23 Surgical Sperm Retrieval 279
Muhammad A. Akhtar, Elizabeth Hester, Solmaz Gul Sajjad, and Yasmin Sajjad

24 In Vitro Fertilization and Intracytoplasmic Sperm Injection 291
Bryan Woodward

25 Morphological Assessment of Embryos in Culture 303
J. Diane Critchlow

26 In Vitro Culture of Gametes and Embryos – The Culture Medium 317
Robbie Kerr

27 Incubators in the Assisted Reproductive Technology Laboratory 333
Louise Hyslop

28 Embryo Transfer Techniques and Improving Embryo Implantation Rates 341
Rachel Cutting

29 Cryopreservation of Gametes and Embryos 351
Tope Adeniyi

30 Preimplantation Genetic Diagnosis and Screening 371
Colleen Lynch and Brendan Ball

31 Long‐Term Follow‐Up of Children Conceived Through In Vitro Fertilization 385
Omar Abdel‐Mannan and Alastair G. Sutcliffe

Index 393