Managing Myeloproliferative Neoplasms

This is a concise, practical, case-based book documenting examples and scenarios that will help you manage challenging clinical issues for patients with myeloproliferative neoplasms. The editors and authors have strived to distil the very latest information in this rapidly advancing field in a way that will help you to update your practice and manage your patients. The key focuses are: diagnosis, both standard and challenging; both day-to-day management as well as special situations such as surgery, thrombotic events and pregnancy; and finally, managing evolving situations with MPN such as progression to acute myeloid leukemia. This book is an outstanding resource that includes a discussion of both classical myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera and myelofibrosis, and also less common disorders such as systemic mast cell disease, hypereosinophilia, MPN/MBS overlap syndromes and atypical CML, amongst others. This book is a practical reference for practitioners, hematologists, medical oncologists and trainees.

    A useful guide for providers across the world managing patients with myeloproliferative neoplasms
    The practical case-based approach makes this book particularly suitable for training individuals in the care of hematology patients, from major cancer centers to community hematologists and medical oncologists
    Provides detailed information about uncommon myeloproliferative neoplasms, for which there is little good clinical guidance in existing literature

Contents

Preface
1. Initial assessment of the undiagnosed patient who has an erythrocytosis, leucocytosis or thrombocytosis Mary Frances McMullin
2. Practical approaches to molecular testing and diagnosis of mastocytosis, hypereosinophilia and MDS/MPN overlap syndromes Nicholas C. P. Cross, Dimitra Koumaki, Georgia Metzgeroth and Andreas Reiter
3. Incidental splenomegaly: an approach to diagnosis Craig B. Reeder
4. When to do a bone marrow biopsy and how to interpret it in the diagnosis of myeloproliferative neoplasm Hans Michael Kvasnicka
5. Accurately assessing risk in your myeloproliferative neoplasm patient Francisco Cervantes and Arturo Pereira
6. Incorporating symptomatic assessment in therapy choice for patients with myeloproliferative neoplasms Robyn M. Scherber, Holly L. Geyer and Ruben A. Mesa
7. The newly diagnosed patient with essential thrombocythemia Guido Finazzi
8. The newly diagnosed patient with polycythemia vera Alessandro M. Vannucchi and Paola Guglielmelli
9. Longstanding polycythemia vera and essential thrombocythemia: monitoring and management goals Loula Papageorgiou and Claire Harrison
10. Management of myelofibrosis: which patients are candidates for JAK inhibitors and how to manage patients on JAK inhibitor treatment Lorenzo Falchi and Srdan Verstovsek
11. Hematopoietic cell transplantation for myelofibrosis: who and when? Veena Fauble and Vikas Gupta
12. Systemic mast cell disease, diagnosis and management Deepti Radia
13. Hypereosinophilia: an illustrated approach to diagnosis and management Jason Gotlib
14. Myelodysplastic/myeloproliferative neoplasm overlap syndromes Aaron T. Gerds, Ramon V. Tiu and Mikkael A. Sekeres
15. Atypical chronic myeloid leukemia and chronic neutrophilic leukemia Daniel A. Pollyea and Jeffrey T. Schowinsky
16. Women and children with myeloproliferative neoplasms – special considerations Robert Schneidewend and Laura C. Michaelis
17. Conception and pregnancy in myeloproliferative neoplasms Susan Robinson
18. Managing acute vascular events in patients with myeloproliferative neoplasms David Garcia and Bethany T. Samuelson
19. Challenging thrombotic scenarios in the myeloproliferative neoplasms: splanchnic vein thrombosis and others Brady L. Stein
20. Familial myeloproliferative neoplasms – implications for patients and their families Sabina Swierczek and Josef Prchal
21. Management of acute leukemia following myeloproliferative neoplasms Raoul Tibes
Index.

Ruben A. Mesa, Mayo Clinic Cancer Center, Arizona
Ruben A. Mesa is a consultant hematologist and Chair of the Division of Hematology and Medical Oncology at the Mayo Clinic, Scottsdale, AZ, USA.

Claire Harrison, Guy’s and St Thomas’ Hospital, London
Claire Harrison is a consultant hematologist and Deputy Clinical Director in Cancer and Haematology at Guy's and St Thomas' NHS Foundation Trust, London, UK.
Contributors

Mary Frances McMullin, Nicholas C. P. Cross, Dimitra Koumaki, Georgia Metzgeroth, Andreas Reiter, Craig B. Reeder, Hans Michael Kvasnicka, Francisco Cervantes, Arturo Pereira, Robyn M. Scherber, Holly L. Geyer, Ruben A. Mesa, Guido Finazzi, Alessandro M. Vannucchi, Paola Guglielmelli, Loula Papageorgiou, Claire Harrison, Lorenzo Falchi, Srdan Verstovsek, Veena Fauble, Vikas Gupta, Deepti Radia, Jason Gotlib, Aaron T. Gerds, Ramon V. Tiu, Mikkael A. Sekeres, Daniel A. Pollyea, Jeffrey T. Schowinsky, Robert Schneidewend, Laura C. Michaelis, Susan Robinson, David Garcia, Bethany T. Samuelson, Brady L. Stein, Sabina Swierczek, Josef Prchal, Raoul Tibes