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This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.The book is packaged with a password, giving the user online access to all the text and images.
Cambridge University Press
December 4, 2014
About the author
Gabor G. Kovacs is an Associate Professor at the Institute of Neurology in Vienna, Austria.
Advance praise: 'Neuropathology of Neurodegenerative Diseases: A Practical Guide edited by Gabor Kovacs is a highly recommended book, written from the perspective of both neuropathologist and clinician. This practical guide is comprehensively updated with the most recent morphological and genetic advancements in the differential diagnoses of neurodegenerative diseases. The supreme author team introduces the core concept of neurodegenerative disorders and guides the reader systematically from the basic practical approach in sampling of brain tissue, histological staining, and molecular methods toward clinical-pathological description of specific proteinopathy. With its extensive combination of masterfully edited text, easy-to-read tables, graphs and high-quality illustrations, this practical guide makes learning and reading of neurodegenerative disorders easy and enjoyable.' Nenad Bogdanovic, Oslo University and Karolinska Institutet, Stockholm
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