Testosterone

Now in its fourth edition Testosterone: Action, Deficiency, Substitution provides the most up-to-date and comprehensive source of information on testosterone and its role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behavior, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and the prostate. The therapeutic uses of testosterone preparations are carefully evaluated as well as its abuse and detection in competitive sport. This new edition also devotes sections to exploring the effects of testosterone on female physiology and sexual function, and the experimental use of testosterone in male hormonal contraception. Testosterone: Action, Deficiency, Substitution has been written and edited by world experts in the fields of clinical andrology and endocrinology and provides a unique and invaluable guide for andrologists, endocrinologists, urologists, internists and those working in reproductive medicine. Features • Key messages at the end of each chapter provide a quick overview • Physicians benefit from clear instructions on diagnosis and treatment of testosterone deficiency and hypogonadism • Most up-to-date comprehensive source on testosterone on the market Edited by: Eberhard Nieschlag, Institute of Reproductive Medicine, University of Munster Edited by: Hermann M. Behre, Reproductive Medicine Unit, Martin Luther University Halle-Wittenberg Table of Contents Preface 1. The medical and cultural history of testosterone and the testes Eberhard Nieschlag and Susan Nieschlag 2. Testosterone: biosynthesis, transport, metabolism and (non-genomic) actions C. Marc Luetjens and Gerhard F. Weinbauer 3. Pathophysiology of the androgen receptor Olaf Hiort, R. Werner and Michael Zitzmann 4. Methodology for measuring testosterone, DHT and SHBG in a clinical setting Manuela Simoni, Flaminia Fanelli, Laura Roli and Uberto Pagotto 5. The behavioral correlates of testosterone John Bancroft 6. The role of testosterone in spermatogenesis Liza O'Donnell and Robert I. McLachlan 7. Androgens and hair: a biological paradox with clinical consequences Valerie Anne Randall 8. Testosterone and bone Dirk Vanderschueren, Mieke Sinnesael, E. Gielen, F. Claessens and S. Boonen 9. Androgens effects on the skeletal muscle Shalender Bhasin, Ravi Jasuja, Carlo Serra, Rajan Singh, Thomas W. Storer, Wen Guo, Thomas G. Travison and Shezad Basaria 10. Testosterone and cardiovascular disease Kevin S. Channer and T. Hugh Jones 11. Testosterone, obesity, diabetes and the metabolic syndrome T. Hugh Jones and Kevin S. Channer 12. Testosterone and erection Mario Maggi and Hermann M. Behre 13. Testosterone and the prostate John T. Isaacs and Samuel R. Denmeade 14. Clinical use of testosterone in hypogonadism and other conditions Eberhard Nieschlag and Hermann M. Behre 15. Testosterone preparations for clinical use in males Hermann M. Behre and Eberhard Nieschlag 16. Androgens in male senescence Jean-Marc Kaufman, Guy T'Sojen and Alex Verleulen 17. Androgen therapy in non-gonadal disease David J. Handelsman 18. Review of guidelines on diagnosis and treatment of testosterone deficiency Ronald S. Swerdloff and Christina C. L. Wang 19. Pathophysiology of estrogen action in men Vincenzo Rochira, Daniele Santi and Cesare Carani 20. Dehydroepiandrosterone (DHEA) and androstenedione Bruno Allolio, Wiebke Arlt and Stefanie Hahner 21. The state-of-the-art in the development of selective androgen receptor modulators (SARMs) Ravi Jasuja, M. Zacharov and Shalender Bhasin 22. The essential role of testosterone in hormonal male contraception Eberhard Nieschlag and Hermann M. Behre 23. Testosterone use in women Susan R. Davis 24. Detection of illegal use of androgens and SARMs Wilhelm Schänzer and Mario Thevis 25. Clinical effects of doping with anabolic steroids Elena Vorona and Eberhard Nieschlag Index.