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The Science and Clinical Application of Manual Therapy is a multi-disciplinary, international reference book based on work by the top basic science researchers and clinical researchers in the area of Manual Therapy and Manual Medicine (MT/MM). The first book to bring together research on the benefits of MT/MM beyond the known effects on musculoskeletal disorders, it presents evidence of the benefit of MT/MM in treating systemic disorders such as asthma, heart rate dysfunction and GI disturbance. Hollis King , DO PhD, Professor of Osteopathic Principles and Practice, AT Still University School of Osteopathic Medicine in Arizona, USA Wilfrid J nig , MD PhD, Professor of Physiology, Physiologisches Institut, Universit t Kiel, Germany Michael Patterson , PhD, Professor of Osteopathic Principles and Practices, College of Osteopathic Medicine, Nova Southeastern University, Florida, USA. CONTENTS 1 The Concepts of Osteopathic Medicine: Past and Present SECTION 1 PERIPHERAL AND SPINAL VISCERO- SOMATIC MECHANISMS 2 Functions of the Autonomic Nervous System: Current Concepts 3 Somatosympathetic Reflex Mechanisms 4 Modulation of Visceral Function by Somatic Stimulation 5 Manual Medicine and Autonomic Nervous System: Assessing Autonomic Function in Humans 6 Survey of Mechanotransduction Disorders SECTION 2 SEGMENTAL AND SUPRASEGMENTAL MEDIATION OF SOMATO-VISCERAL INTERACTIONS 7 Spinothalamic System and Viscero-somatic Motor Reflexes: Functional Organization of Cardiac and Somatic Input 8 Central Convergence of Viscersomatic Inputs from Spinal and Vagal Sources 9 Role of oxytocin and oxytocin related effects in manual therapies 10 Viscero-Sensory Pathways in the Brain 11 The Use of Sham or Placebo Controls in Manual Medicine Research SECTION 3 CLINICAL IMPACT OF MANUAL THERAPY ON PHYSIOLOGIC FUNCTIONS AND SYSTEMIC DISORDERS 12 Research on Somato-Visceral Interactions and the Impact of Manual Therapy on Systemic Disorders from the Osteopathic Experience 13 Chiropractic Practice, Experience and Research Related to Somato-Visceral Interactions 14 A Physical Therapist's Perspective on Manual Therapy: Clinical Effectiveness and Selected Mechanism 15 Therapeutic Massage and Bodywork: Overview of the Practice and Evidence of a Developing Health Profession CONSENSUS STATEMENTS 16 Basic Science on Somato-Visceral Interactions: Peripheral and Central Evidence Base and Implications for Research 17 Clinical Applications of Manual Therapy on Physiologic Functions and Systemic Disorders: Evidence Base and Implications for Research